Literature DB >> 26477263

In Vivo pO2 Imaging of Tumors: Oxymetry with Very Low-Frequency Electron Paramagnetic Resonance.

Boris Epel1, Howard J Halpern2.   

Abstract

For over a century, it has been known that tumor hypoxia, regions of a tumor with low levels of oxygenation, are important contributors to tumor resistance to radiation therapy and failure of radiation treatment of cancer. Recently, using novel pulse electron paramagnetic resonance (EPR) oxygen imaging, near absolute images of the partial pressure of oxygen (pO2) in tumors of living animals have been obtained. We discuss here the means by which EPR signals can be obtained in living tissues and tumors. We review development of EPR methods to image the pO2 in tumors and the potential for the pO2 image acquisition in human subjects.
© 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Elecctron paramagnetic resonance imaging; Image registration; Molecular O(2) imaging; Quantitative physiologic imaging

Mesh：

Substances：

Year:  2015        PMID： 26477263      PMCID： PMC4749023          DOI： 10.1016/bs.mie.2015.08.017

Source DB:  PubMed          Journal:  Methods Enzymol        ISSN： 0076-6879            Impact factor:   1.600


  62 in total

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Authors:  Benjamin B Williams; Hania al Hallaq; G V R Chandramouli; Eugene D Barth; Jonathan N Rivers; Marta Lewis; Valeri E Galtsev; Gregory S Karczmar; Howard J Halpern
Journal:  Magn Reson Med       Date:  2002-04       Impact factor: 4.668

2.  Magnetic resonance imaging of blood vessels at high fields: in vivo and in vitro measurements and image simulation.

Authors:  S Ogawa; T M Lee
Journal:  Magn Reson Med       Date:  1990-10       Impact factor: 4.668

Review 3.  Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy.

Authors:  James L Tatum; Gary J Kelloff; Robert J Gillies; Jeffrey M Arbeit; J Martin Brown; K S Clifford Chao; J Donald Chapman; William C Eckelman; Anthony W Fyles; Amato J Giaccia; Richard P Hill; Cameron J Koch; Murali Cherukuri Krishna; Kenneth A Krohn; Jason S Lewis; Ralph P Mason; Giovanni Melillo; Anwar R Padhani; Garth Powis; Joseph G Rajendran; Richard Reba; Simon P Robinson; Gregg L Semenza; Harold M Swartz; Peter Vaupel; David Yang; Barbara Croft; John Hoffman; Guoying Liu; Helen Stone; Daniel Sullivan
Journal:  Int J Radiat Biol       Date:  2006-10       Impact factor: 2.694

4.  Detection of the kinetics of biochemical reactions with oxygen using exchange broadening in the ESR spectra of nitroxide radicals.

Authors:  J M Backer; V G Budker; S I Eremenko; Y N Molin
Journal:  Biochim Biophys Acta       Date:  1977-04-11

5.  Tumor oximetry: demonstration of an enhanced dynamic mapping procedure using fluorine-19 echo planar magnetic resonance imaging in the Dunning prostate R3327-AT1 rat tumor.

Authors:  S Hunjan; D Zhao; A Constantinescu; E W Hahn; P P Antich; R P Mason
Journal:  Int J Radiat Oncol Biol Phys       Date:  2001-03-15       Impact factor: 7.038

6.  Imaging of phosphorescence: a novel method for measuring oxygen distribution in perfused tissue.

Authors:  W L Rumsey; J M Vanderkooi; D F Wilson
Journal:  Science       Date:  1988-09-23       Impact factor: 47.728

7.  Three-dimensional spectral-spatial EPR imaging of free radicals in the heart: a technique for imaging tissue metabolism and oxygenation.

Authors:  P Kuppusamy; M Chzhan; K Vij; M Shteynbuk; D J Lefer; E Giannella; J L Zweier
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-12       Impact factor: 11.205

8.  Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation.

Authors:  J M Brown
Journal:  Br J Radiol       Date:  1979-08       Impact factor: 3.039

9.  Characterization of response to radiation mediated gene therapy by means of multimodality imaging.

Authors:  Chad R Haney; Adrian D Parasca; Xiaobing Fan; Rebecca M Bell; Marta A Zamora; Gregory S Karczmar; Helena J Mauceri; Howard J Halpern; Ralph R Weichselbaum; Charles A Pelizzari
Journal:  Magn Reson Med       Date:  2009-08       Impact factor: 4.668

10.  EPR oxygen images predict tumor control by a 50% tumor control radiation dose.

Authors:  Martyna Elas; Jessica M Magwood; Brandi Butler; Chanel Li; Rona Wardak; Rebekah DeVries; Eugene D Barth; Boris Epel; Samuel Rubinstein; Charles A Pelizzari; Ralph R Weichselbaum; Howard J Halpern
Journal:  Cancer Res       Date:  2013-07-16       Impact factor: 12.701
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  22 in total

1.  Effect of body temperature on the pharmacokinetics of a triarylmethyl-type paramagnetic contrast agent used in EPR oximetry.

Authors:  Ken-Ichiro Matsumoto; Fuminori Hyodo; James B Mitchell; Murali C Krishna
Journal:  Magn Reson Med       Date:  2017-11-16       Impact factor: 4.668

2.  Dextran-conjugated tetrathiatriarylmethyl radicals as biocompatible spin probes for EPR spectroscopy and imaging.

Authors:  Martin Poncelet; Benoit Driesschaert; Oxana Tseytlin; Mark Tseytlin; Timothy D Eubank; Valery V Khramtsov
Journal:  Bioorg Med Chem Lett       Date:  2019-05-13       Impact factor: 2.823

Review 3.  In Vivo Application of Proton-Electron Double-Resonance Imaging.

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Journal:  Antioxid Redox Signal       Date:  2017-11-13       Impact factor: 8.401

4.  Chemical exchange induced Hahn echo modulation in pulsed electron paramagnetic resonance experiment.

Authors:  Andrey A Bobko
Journal:  J Magn Reson       Date:  2020-05-16       Impact factor: 2.229

Review 5.  Exchange Phenomena in the Electron Paramagnetic Resonance Spectra of the Nitroxyl and Trityl Radicals: Multifunctional Spectroscopy and Imaging of Local Chemical Microenvironment.

Authors:  Valery V Khramtsov; Andrey A Bobko; Mark Tseytlin; Benoit Driesschaert
Journal:  Anal Chem       Date:  2017-04-10       Impact factor: 6.986

Review 6.  Oxygenic photosynthesis: EPR study of photosynthetic electron transport and oxygen-exchange, an overview.

Authors:  Alexander N Tikhonov; Witold K Subczynski
Journal:  Cell Biochem Biophys       Date:  2018-11-20       Impact factor: 2.194

Review 7.  In Vivo Molecular Electron Paramagnetic Resonance-Based Spectroscopy and Imaging of Tumor Microenvironment and Redox Using Functional Paramagnetic Probes.

Authors:  Valery V Khramtsov
Journal:  Antioxid Redox Signal       Date:  2017-12-20       Impact factor: 8.401

8.  Background correction in rapid scan EPR spectroscopy.

Authors:  Laura A Buchanan; Lukas B Woodcock; Richard W Quine; George A Rinard; Sandra S Eaton; Gareth R Eaton
Journal:  J Magn Reson       Date:  2018-05-17       Impact factor: 2.229

9.  Oxygen-induced leakage of spin polarization in Overhauser-enhanced magnetic resonance imaging: Application for oximetry in tumors.

Authors:  Artem A Gorodetskii; Timothy D Eubank; Benoit Driesschaert; Martin Poncelet; Emily Ellis; Valery V Khramtsov; Andrey A Bobko
Journal:  J Magn Reson       Date:  2018-10-10       Impact factor: 2.229

10.  13C isotope enrichment of the central trityl carbon decreases fluid solution electron spin relaxation times.

Authors:  Whylder Moore; Joseph E McPeak; Martin Poncelet; Benoit Driesschaert; Sandra S Eaton; Gareth R Eaton
Journal:  J Magn Reson       Date:  2020-07-28       Impact factor: 2.229
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