Brandilyn A Peters1, Megan N Hall2, Xinhua Liu3, Vesna Slavkovich1, Vesna Ilievski1, Shafiul Alam4, Abu B Siddique4, Tariqul Islam4, Joseph H Graziano1, Mary V Gamble5. 1. Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA. 2. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. 3. Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA. 4. Columbia University Arsenic Project in Bangladesh, Dhaka, Bangladesh. 5. Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address: mvg7@cumc.columbia.edu.
Abstract
BACKGROUND: Arsenic (As) methylation capacity in epidemiologic studies is typically indicated by the proportions of inorganic As (%InAs), monomethylarsonic acid (%MMA), and dimethylarsinic acid (%DMA) in urine as a fraction of total urinary As. The relationship between renal function and indicators of As methylation capacity has not been thoroughly investigated. OBJECTIVES: Our two aims were to examine (1) associations between estimated glomerular filtration rate (eGFR) and %As metabolites in blood and urine, and (2) whether renal function modifies the relationship of blood %As metabolites with respective urinary %As metabolites. METHODS: In a cross-sectional study of 375 As-exposed Bangladeshi adults, we measured blood and urinary As metabolites, and calculated eGFR from plasma cystatin C. RESULTS: In covariate-adjusted linear models, a 1 ml/min/1.73 m(2) increase in eGFR was associated with a 0.39% increase in urinary %InAs (p<0.0001) and a mean decrease in urinary %DMA of 0.07 (p=0.0005). In the 292 participants with measurable blood As metabolites, the associations of eGFR with increased blood %InAs and decreased blood %DMA did not reach statistical significance. eGFR was not associated with urinary or blood %MMA in covariate-adjusted models. For a given increase in blood %InAs, the increase in urinary %InAs was smaller in those with reduced eGFR, compared to those with normal eGFR (p=0.06); this effect modification was not observed for %MMA or %DMA. CONCLUSIONS: Urinary excretion of InAs may be impaired in individuals with reduced renal function. Alternatively, increased As methylation capacity (as indicated by decreased urinary %InAs) may be detrimental to renal function.
BACKGROUND:Arsenic (As) methylation capacity in epidemiologic studies is typically indicated by the proportions of inorganic As (%InAs), monomethylarsonic acid (%MMA), and dimethylarsinic acid (%DMA) in urine as a fraction of total urinary As. The relationship between renal function and indicators of As methylation capacity has not been thoroughly investigated. OBJECTIVES: Our two aims were to examine (1) associations between estimated glomerular filtration rate (eGFR) and %As metabolites in blood and urine, and (2) whether renal function modifies the relationship of blood %As metabolites with respective urinary %As metabolites. METHODS: In a cross-sectional study of 375 As-exposed Bangladeshi adults, we measured blood and urinary As metabolites, and calculated eGFR from plasma cystatin C. RESULTS: In covariate-adjusted linear models, a 1 ml/min/1.73 m(2) increase in eGFR was associated with a 0.39% increase in urinary %InAs (p<0.0001) and a mean decrease in urinary %DMA of 0.07 (p=0.0005). In the 292 participants with measurable blood As metabolites, the associations of eGFR with increased blood %InAs and decreased blood %DMA did not reach statistical significance. eGFR was not associated with urinary or blood %MMA in covariate-adjusted models. For a given increase in blood %InAs, the increase in urinary %InAs was smaller in those with reduced eGFR, compared to those with normal eGFR (p=0.06); this effect modification was not observed for %MMA or %DMA. CONCLUSIONS: Urinary excretion of InAs may be impaired in individuals with reduced renal function. Alternatively, increased As methylation capacity (as indicated by decreased urinary %InAs) may be detrimental to renal function.
Authors: Lesley A Inker; Christopher H Schmid; Hocine Tighiouart; John H Eckfeldt; Harold I Feldman; Tom Greene; John W Kusek; Jane Manzi; Frederick Van Lente; Yaping Lucy Zhang; Josef Coresh; Andrew S Levey Journal: N Engl J Med Date: 2012-07-05 Impact factor: 91.245
Authors: Craig Steinmaus; Yan Yuan; Dave Kalman; Omar A Rey; Christine F Skibola; Dave Dauphine; Anamika Basu; Kristin E Porter; Alan Hubbard; Michael N Bates; Martyn T Smith; Allan H Smith Journal: Toxicol Appl Pharmacol Date: 2010-06-17 Impact factor: 4.219
Authors: Paige A Bommarito; Xiaofan Xu; Carmen González-Horta; Blanca Sánchez-Ramirez; Lourdes Ballinas-Casarrubias; René Santos Luna; Susana Román Pérez; Juan Eugenio Hernández Ávila; Gonzalo G García-Vargas; Luz M Del Razo; Mirek Stýblo; Michelle A Mendez; Rebecca C Fry Journal: Environ Int Date: 2018-12-13 Impact factor: 9.621
Authors: Maria Grau-Pérez; Chin-Chi Kuo; Miranda Spratlen; Kristina A Thayer; Michelle A Mendez; Richard F Hamman; Dana Dabelea; John L Adgate; William C Knowler; Ronny A Bell; Frederick W Miller; Angela D Liese; Chongben Zhang; Christelle Douillet; Zuzana Drobná; Elizabeth J Mayer-Davis; Miroslav Styblo; Ana Navas-Acien Journal: Diabetes Care Date: 2016-11-03 Impact factor: 19.112
Authors: Dayana A Delgado; Meytal Chernoff; Lei Huang; Lin Tong; Lin Chen; Farzana Jasmine; Justin Shinkle; Shelley A Cole; Karin Haack; Jack Kent; Jason Umans; Lyle G Best; Heather Nelson; Donald Vander Griend; Joseph Graziano; Muhammad G Kibriya; Ana Navas-Acien; Margaret R Karagas; Habibul Ahsan; Brandon L Pierce Journal: Environ Health Perspect Date: 2021-04-07 Impact factor: 9.031
Authors: Shohreh F Farzan; Caitlin G Howe; Michael S Zens; Thomas Palys; Jacqueline Y Channon; Zhigang Li; Yu Chen; Margaret R Karagas Journal: Environ Health Perspect Date: 2017-12-15 Impact factor: 9.031