Literature DB >> 26476099

Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis.

Dongyan Tan1, Neil B Blok1,2, Tom A Rapoport1,2, Thomas Walz3.   

Abstract

The Pex1 and Pex6 proteins are members of the AAA family of ATPases and are involved in peroxisome biogenesis. Recently, cryo-electron microscopy structures of the Pex1-Pex6 complex in different nucleotide states have been determined. This Structural Snapshot describes the structural features of the complex and their implications for its function, as well as questions that still await answers.
© 2015 FEBS.

Entities:  

Keywords:  AAA ATPases; Pex1-Pex6 complex; cryo-electron microscopy; peroxisome biogenesis; single-particle analysis

Mesh：

Substances：

Year:  2015        PMID： 26476099      PMCID： PMC4803591          DOI： 10.1111/febs.13569

Source DB:  PubMed          Journal:  FEBS J        ISSN： 1742-464X            Impact factor:   5.542


  35 in total

Review 1.  The AAA-type ATPases Pex1p and Pex6p and their role in peroxisomal matrix protein import in Saccharomyces cerevisiae.

Authors:  Immanuel Grimm; Delia Saffian; Harald W Platta; Ralf Erdmann
Journal:  Biochim Biophys Acta       Date:  2011-09-22

2.  ATP-dependent assembly of the heteromeric Pex1p-Pex6p-complex of the peroxisomal matrix protein import machinery.

Authors:  Delia Saffian; Immanuel Grimm; Wolfgang Girzalsky; Ralf Erdmann
Journal:  J Struct Biol       Date:  2012-06-16       Impact factor: 2.867

Review 3.  Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system.

Authors:  Hemmo Meyer; Monika Bug; Sebastian Bremer
Journal:  Nat Cell Biol       Date:  2012-02-02       Impact factor: 28.824

Review 4.  Recent advances in peroxisomal matrix protein import.

Authors:  Xueqian Liu; Changle Ma; Suresh Subramani
Journal:  Curr Opin Cell Biol       Date:  2012-06-08       Impact factor: 8.382

Review 5.  Peroxisome biogenesis disorders: Biological, clinical and pathophysiological perspectives.

Authors:  Nancy E Braverman; Maria Daniela D'Agostino; Gillian E Maclean
Journal:  Dev Disabil Res Rev       Date:  2013

6.  The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits.

Authors:  Brooke M Gardner; Saikat Chowdhury; Gabriel C Lander; Andreas Martin
Journal:  J Mol Biol       Date:  2015-02-07       Impact factor: 5.469

7.  Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation.

Authors:  Marta Carroni; Eva Kummer; Yuki Oguchi; Petra Wendler; Daniel K Clare; Irmgard Sinning; Jürgen Kopp; Axel Mogk; Bernd Bukau; Helen R Saibil
Journal:  Elife       Date:  2014-04-30       Impact factor: 8.140

8.  Mechanistic insights into the recycling machine of the SNARE complex.

Authors:  Minglei Zhao; Shenping Wu; Qiangjun Zhou; Sandro Vivona; Daniel J Cipriano; Yifan Cheng; Axel T Brunger
Journal:  Nature       Date:  2015-01-12       Impact factor: 49.962

Review 9.  Cleaning up in the endoplasmic reticulum: ubiquitin in charge.

Authors:  John C Christianson; Yihong Ye
Journal:  Nat Struct Mol Biol       Date:  2014-04       Impact factor: 18.361

10.  Mechanochemical basis of protein degradation by a double-ring AAA+ machine.

Authors:  Adrian O Olivares; Andrew R Nager; Ohad Iosefson; Robert T Sauer; Tania A Baker
Journal:  Nat Struct Mol Biol       Date:  2014-09-07       Impact factor: 15.369
View more
  8 in total

1.  Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol.

Authors:  Ana G Pedrosa; Tânia Francisco; Diana Bicho; Ana F Dias; Aurora Barros-Barbosa; Vera Hagmann; Gabriele Dodt; Tony A Rodrigues; Jorge E Azevedo
Journal:  J Biol Chem       Date:  2018-06-08       Impact factor: 5.157

2.  Sending protein aggregates into a downward spiral.

Authors:  Steven E Glynn; Peter Chien
Journal:  Nat Struct Mol Biol       Date:  2016-09-06       Impact factor: 15.369

Review 3.  Pexophagy is responsible for 65% of cases of peroxisome biogenesis disorders.

Authors:  Taras Y Nazarko
Journal:  Autophagy       Date:  2017-02-28       Impact factor: 16.016

Review 4.  Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging.

Authors:  Jinoh Kim; Hua Bai
Journal:  Antioxidants (Basel)       Date:  2022-01-19

Review 5.  Insights into the Structure and Function of the Pex1/Pex6 AAA-ATPase in Peroxisome Homeostasis.

Authors:  Ryan M Judy; Connor J Sheedy; Brooke M Gardner
Journal:  Cells       Date:  2022-06-29       Impact factor: 7.666

6.  Shedding light on the expansion and diversification of the Cdc48 protein family during the rise of the eukaryotic cell.

Authors:  Nickias Kienle; Tobias H Kloepper; Dirk Fasshauer
Journal:  BMC Evol Biol       Date:  2016-10-18       Impact factor: 3.260

7.  Peroxisome biogenesis disorders.

Authors:  Catherine Argyriou; Maria Daniela D'Agostino; Nancy Braverman
Journal:  Transl Sci Rare Dis       Date:  2016-11-07

8.  Chemically monoubiquitinated PEX5 binds to the components of the peroxisomal docking and export machinery.

Authors:  Vera Hagmann; Stefanie Sommer; Patrick Fabian; Jan Bierlmeier; Nadine van Treel; Henning D Mootz; Dirk Schwarzer; Jorge E Azevedo; Gabriele Dodt
Journal:  Sci Rep       Date:  2018-10-30       Impact factor: 4.379
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.