| Literature DB >> 26471351 |
E J Gong1, D H Kim2, J Y Ahn1, K-S Choi1, K W Jung1, J H Lee1, K D Choi1, H J Song1, G H Lee1, H-Y Jung1, J H Kim1, J-L Roh3, S-H Choi3, S Y Nam3, S Y Kim3.
Abstract
Early detection of synchronous esophageal squamous cell neoplasm (ESCN) in head and neck squamous cell carcinoma (HNSCC) patients can significantly affect their prognosis. We investigated the prevalence of synchronous ESCN and the risk factors for developing ESCN in patients with HNSCC, and evaluated the effect of routine endoscopic screening in these patients. Subjects who were diagnosed as HNSCC from May 2010 to January 2014 were eligible. All patients underwent conventional white light endoscopic examinations with narrow band imaging and Lugol chromoendoscopy. Among 458 subjects screened, 28 synchronous ESCN were detected in 24 patients (5.2%). The prevalence of ESCN was greatest in patients with hypopharyngeal cancer (20.9%). In multivariate analysis, pyriform sinus involvement was independent risk factor for developing synchronous ESCN (odds ratio 171.2, P < 0.001). During the follow-up period (median, 24 months), the 3-year overall survival rates was significantly lower in patients with ESCN than in patients without ESCN (54.2% vs. 78.3%, P = 0.0013). Routine endoscopic screening for detecting synchronous ESCN should be recommended for patients with HNSCC, especially those with pyriform sinus involvement.Entities:
Keywords: esophageal neoplasm; head and neck neoplasm; second primary neoplasm
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Year: 2015 PMID： 26471351 DOI： 10.1111/dote.12404
Source DB: PubMed Journal: Dis Esophagus ISSN： 1120-8694 Impact factor: 3.429