BACKGROUND/AIM: To analyze the clinical features and prevalence of synchronous and metachronous second primary malignancies (SPMs) in patients with hypopharyngeal squamous cell carcinoma (HSCC), their associated risk factors, and cause-specific mortality. PATIENTS AND METHODS: We retrospectively reviewed 136 patients treated with curative intent at our hospital. Statistical analyses were performed to determine factors predictive of SPM and cause-specific mortality. RESULTS: Sixty-three of 136 patients (46.3%) developed SPM; of these, 41 (30.1%) and 42 (30.9%) had synchronous and metachronous SPMs, respectively, with patient overlap. The most common site of synchronous and metachronous SPMs was the oesophagus (65.8% and 24.4%, respectively); the corresponding overall survival rates were 34.1% and 66.5%, respectively. Furthermore, heavy drinking was significantly correlated with synchronous SPM (p<0.001). CONCLUSION: Oesophageal cancer surveillance is recommended for patients with HSCC, especially heavy drinkers. Our findings may help identify and properly manage HSCC patients at high risk of SPMs. Copyright
BACKGROUND/AIM: To analyze the clinical features and prevalence of synchronous and metachronous second primary malignancies (SPMs) in patients with hypopharyngeal squamous cell carcinoma (HSCC), their associated risk factors, and cause-specific mortality. PATIENTS AND METHODS: We retrospectively reviewed 136 patients treated with curative intent at our hospital. Statistical analyses were performed to determine factors predictive of SPM and cause-specific mortality. RESULTS: Sixty-three of 136 patients (46.3%) developed SPM; of these, 41 (30.1%) and 42 (30.9%) had synchronous and metachronous SPMs, respectively, with patient overlap. The most common site of synchronous and metachronous SPMs was the oesophagus (65.8% and 24.4%, respectively); the corresponding overall survival rates were 34.1% and 66.5%, respectively. Furthermore, heavy drinking was significantly correlated with synchronous SPM (p<0.001). CONCLUSION: Oesophageal cancer surveillance is recommended for patients with HSCC, especially heavy drinkers. Our findings may help identify and properly manage HSCC patients at high risk of SPMs. Copyright
Authors: E J Gong; D H Kim; J Y Ahn; K-S Choi; K W Jung; J H Lee; K D Choi; H J Song; G H Lee; H-Y Jung; J H Kim; J-L Roh; S-H Choi; S Y Nam; S Y Kim Journal: Dis Esophagus Date: 2015-10-15 Impact factor: 3.429
Authors: Jay S Cooper; Kim Porter; Katherine Mallin; Henry T Hoffman; Randal S Weber; Kian K Ang; E Greer Gay; Corey J Langer Journal: Head Neck Date: 2009-06 Impact factor: 3.147
Authors: Klaus Strobel; Stephan K Haerle; Sandro J Stoeckli; Madeleine Schrank; Jan D Soyka; Patrick Veit-Haibach; Thomas F Hany Journal: Eur J Nucl Med Mol Imaging Date: 2009-02-10 Impact factor: 9.236