BACKGROUND AND OBJECTIVES: This study was designed to test whether a brief quantitative sensory testing assessment could be used to detect hyperalgesia in patients with suspected opioid-induced hyperalgesia (OIH). METHODS: Twenty patients on long-term opioid therapy with suspected OIH were recruited along with 20 healthy controls. Pressure pain threshold, Pain50, a measure of intermediate suprathreshold pressure pain sensitivity, and tolerance levels were evaluated. As a secondary outcome, changes in pressure pain sensitivity after intravenous administration of placebo (saline) and fentanyl (1.5 μg/kg) were assessed. RESULTS: There were no significant differences in pain measures between healthy controls and patients. However, there was an association between higher doses of opioids and having a lower pain tolerance (r = -0.46, P = 0.041) and lower Pain50 (r = -0.46, P = 0.044), which was consistent with the hypothesis. Patients on more than 100 mg oral morphine equivalents displayed decreased pressure pain tolerance compared with patients taking less than 100 mg oral morphine equivalents (P = 0.042). In addition, male patients showed a hyperalgesic response to fentanyl administration, which was significant for the Pain50 measure (P = 0.002). CONCLUSIONS: Whereas there were no differences between patients suspected of having OIH and the healthy controls, the finding that higher doses of opioids were associated with more sensitivity suggests that dose might be an important factor in the development of hyperalgesia. In addition, male patients demonstrated a hyperalgesic response after a bolus of fentanyl. Future studies are needed to develop better diagnostics for detecting hyperalgesia in the clinical setting.
BACKGROUND AND OBJECTIVES: This study was designed to test whether a brief quantitative sensory testing assessment could be used to detect hyperalgesia in patients with suspected opioid-induced hyperalgesia (OIH). METHODS: Twenty patients on long-term opioid therapy with suspected OIH were recruited along with 20 healthy controls. Pressure pain threshold, Pain50, a measure of intermediate suprathreshold pressure pain sensitivity, and tolerance levels were evaluated. As a secondary outcome, changes in pressure pain sensitivity after intravenous administration of placebo (saline) and fentanyl (1.5 μg/kg) were assessed. RESULTS: There were no significant differences in pain measures between healthy controls and patients. However, there was an association between higher doses of opioids and having a lower pain tolerance (r = -0.46, P = 0.041) and lower Pain50 (r = -0.46, P = 0.044), which was consistent with the hypothesis. Patients on more than 100 mg oral morphine equivalents displayed decreased pressure pain tolerance compared with patients taking less than 100 mg oral morphine equivalents (P = 0.042). In addition, male patients showed a hyperalgesic response to fentanyl administration, which was significant for the Pain50 measure (P = 0.002). CONCLUSIONS: Whereas there were no differences between patients suspected of having OIH and the healthy controls, the finding that higher doses of opioids were associated with more sensitivity suggests that dose might be an important factor in the development of hyperalgesia. In addition, male patients demonstrated a hyperalgesic response after a bolus of fentanyl. Future studies are needed to develop better diagnostics for detecting hyperalgesia in the clinical setting.
Authors: Ronald A Wasserman; Chad M Brummett; Jenna Goesling; Alex Tsodikov; Afton L Hassett Journal: Reg Anesth Pain Med Date: 2014 Jan-Feb Impact factor: 6.288
Authors: Laxmaiah Manchikanti; Salahadin Abdi; Sairam Atluri; Carl C Balog; Ramsin M Benyamin; Mark V Boswell; Keith R Brown; Brian M Bruel; David A Bryce; Patricia A Burks; Allen W Burton; Aaron K Calodney; David L Caraway; Kimberly A Cash; Paul J Christo; Kim S Damron; Sukdeb Datta; Timothy R Deer; Sudhir Diwan; Ike Eriator; Frank J E Falco; Bert Fellows; Stephanie Geffert; Christopher G Gharibo; Scott E Glaser; Jay S Grider; Haroon Hameed; Mariam Hameed; Hans Hansen; Michael E Harned; Salim M Hayek; Standiford Helm; Joshua A Hirsch; Jeffrey W Janata; Alan D Kaye; Adam M Kaye; David S Kloth; Dhanalakshmi Koyyalagunta; Marion Lee; Yogesh Malla; Kavita N Manchikanti; Carla D McManus; Vidyasagar Pampati; Allan T Parr; Ramarao Pasupuleti; Vikram B Patel; Nalini Sehgal; Sanford M Silverman; Vijay Singh; Howard S Smith; Lee T Snook; Daneshvari R Solanki; Deborah H Tracy; Ricardo Vallejo; Bradley W Wargo Journal: Pain Physician Date: 2012-07 Impact factor: 4.965
Authors: Andrew Schrepf; Catherine S Bradley; Michael O'Donnell; Yi Luo; Steven E Harte; Karl Kreder; Susan Lutgendorf Journal: Brain Behav Immun Date: 2015-03-11 Impact factor: 7.217
Authors: Steven E Harte; Mainak Mitra; Eric A Ichesco; Megan E Halvorson; Daniel J Clauw; Albert J Shih; Grant H Kruger Journal: Med Biol Eng Comput Date: 2013-02-05 Impact factor: 2.602
Authors: T Schmidt-Wilcke; E Ichesco; J P Hampson; A Kairys; S Peltier; S Harte; D J Clauw; R E Harris Journal: Neuroimage Clin Date: 2014-09-16 Impact factor: 4.881
Authors: Ronald A Wasserman; Afton L Hassett; Steven E Harte; Jenna Goesling; Herbert L Malinoff; Daniel W Berland; Jennifer Zollars; Stephanie E Moser; Chad M Brummett Journal: J Nat Sci Date: 2017-02
Authors: Mingxiao Yang; Raymond E Baser; Susan Q Li; Yen-Nien Hou; Kamyar Chong; Yi Lily Zhang; Irfan Hoque; Ting Bao; Jun J Mao Journal: Front Pharmacol Date: 2022-05-04 Impact factor: 5.988
Authors: H Henry Lai; Bruce Naliboff; Alice B Liu; Cindy L Amundsen; Joshua S Shimony; Vincent A Magnotta; Joseph J Shaffer; Robin L Gilliam; Jonathan B Wiseman; Margaret E Helmuth; Victor P Andreev; Ziya Kirkali; Steven E Harte Journal: Contemp Clin Trials Date: 2018-09-21 Impact factor: 2.226
Authors: Tiffany R Bellomo; Andrew Schrepf; Grant H Kruger; Mark A Lumley; Howard Schubiner; Daniel J Clauw; David A Williams; Steven E Harte Journal: Clin J Pain Date: 2020-07 Impact factor: 3.423
Authors: Steven E Harte; Eric Ichesco; Johnson P Hampson; Scott J Peltier; Tobias Schmidt-Wilcke; Daniel J Clauw; Richard E Harris Journal: Pain Date: 2016-09 Impact factor: 7.926
Authors: Andrew Schrepf; Daniel E Harper; Steven E Harte; Heng Wang; Eric Ichesco; Johnson P Hampson; Jon-Kar Zubieta; Daniel J Clauw; Richard E Harris Journal: Pain Date: 2016-10 Impact factor: 7.926
Authors: Steven E Harte; Andrew Schrepf; Robert Gallop; Grant H Kruger; Hing Hung Henry Lai; Siobhan Sutcliffe; Megan Halvorson; Eric Ichesco; Bruce D Naliboff; Niloofar Afari; Richard E Harris; John T Farrar; Frank Tu; John Richard Landis; Daniel J Clauw Journal: Pain Date: 2019-06 Impact factor: 7.926