Literature DB >> 35798932

Amygdala Metabotropic Glutamate Receptor 1 Influences Synaptic Transmission to Participate in Fentanyl-Induced Hyperalgesia in Rats.

Tianyu Bai1, Hengling Chen1, Wenwu Hu1, Jingtao Liu1, Xianguang Lin1, Su Chen1, Fang Luo2, Xiaofei Yang1, Jun Chen3, Chenhong Li4.   

Abstract

The underlying mechanisms of opioid-induced hyperalgesia (OIH) remain unclear. Herein, we found that the protein expression of metabotropic glutamate receptor 1 (mGluR1) was significantly increased in the right but not in the left laterocapsular division of central nucleus of the amygdala (CeLC) in OIH rats. In CeLC neurons, the frequency and the amplitude of mini-excitatory postsynaptic currents (mEPSCs) were significantly increased in fentanyl group which were decreased by acute application of a mGluR1 antagonist, A841720. Finally, the behavioral hypersensitivity could be reversed by A841720 microinjection into the right CeLC. These results show that the right CeLC mGluR1 is an important factor associated with OIH that enhances synaptic transmission and could be a potential drug target to alleviate fentanyl-induced hyperalgesia.
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Amygdala; CeLC; Opioid-induced hyperalgesia; Pain; mGluR1

Year:  2022        PMID： 35798932     DOI： 10.1007/s10571-022-01248-x

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  52 in total

1.  Intraoperative low-dose ketamine does not prevent a remifentanil-induced increase in morphine requirement after pediatric scoliosis surgery.

Authors:  Thomas Engelhardt; Christian Zaarour; Basem Naser; Carolyne Pehora; Joost de Ruiter; Andrew Howard; Mark W Crawford
Journal:  Anesth Analg       Date:  2008-10       Impact factor: 5.108

2.  Knockdown of spinal metabotropic glutamate receptor 1 (mGluR(1)) alleviates pain and restores opioid efficacy after nerve injury in rats.

Authors:  M E Fundytus; K Yashpal; J G Chabot; M G Osborne; C D Lefebvre; A Dray; J L Henry; T J Coderre
Journal:  Br J Pharmacol       Date:  2001-01       Impact factor: 8.739

3.  Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist.

Authors:  O El-Kouhen; S G Lehto; J B Pan; R Chang; S J Baker; C Zhong; P R Hollingsworth; J P Mikusa; E A Cronin; K L Chu; S P McGaraughty; M E Uchic; L N Miller; N M Rodell; M Patel; P Bhatia; M Mezler; T Kolasa; G Z Zheng; G B Fox; A O Stewart; M W Decker; R B Moreland; J D Brioni; P Honore
Journal:  Br J Pharmacol       Date:  2006-10-03       Impact factor: 8.739

4.  Molecular and electrophysiological changes in the prefrontal cortex-amygdala-dorsal periaqueductal grey pathway during persistent pain state and fear-conditioned analgesia.

Authors:  Ryan K Butler; Linda Nilsson-Todd; Carine Cleren; Isabelle Léna; René Garcia; David P Finn
Journal:  Physiol Behav       Date:  2011-06-12

5.  Activation of the extracellular signal-regulated kinase in the amygdala modulates pain perception.

Authors:  Yarimar Carrasquillo; Robert W Gereau
Journal:  J Neurosci       Date:  2007-02-14       Impact factor: 6.167

6.  Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine.

Authors:  E Célèrier; C Rivat; Y Jun; J P Laulin; A Larcher; P Reynier; G Simonnet
Journal:  Anesthesiology       Date:  2000-02       Impact factor: 7.892

Review 7.  Sex differences in opioid analgesia, hyperalgesia, tolerance and withdrawal: central mechanisms of action and roles of gonadal hormones.

Authors:  Richard J Bodnar; Benjamin Kest
Journal:  Horm Behav       Date:  2009-09-26       Impact factor: 3.587

8.  Capsaicin-induced hyperalgesia and mu-opioid-induced antihyperalgesia in male and female Fischer 344 rats.

Authors:  Andrew C Barrett; Eric S Smith; Mitchell J Picker
Journal:  J Pharmacol Exp Ther       Date:  2003-09-03       Impact factor: 4.030

9.  Activation of mGluR1 contributes to neuronal hyperexcitability in the rat anterior cingulate cortex via inhibition of HCN channels.

Authors:  Shi-Hao Gao; Hui-Zhong Wen; Lin-Lin Shen; Yan-Dong Zhao; Huai-Zhen Ruan
Journal:  Neuropharmacology       Date:  2016-01-29       Impact factor: 5.250

10.  Hemispheric lateralization of a molecular signal for pain modulation in the amygdala.

Authors:  Yarimar Carrasquillo; Robert W Gereau
Journal:  Mol Pain       Date:  2008-06-23       Impact factor: 3.395
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