David A Williams1. 1. Department of Anesthesiology, University of Michigan Health System, 24 Frank Lloyd Wright Drive, P.O. Box 385, Lobby M, Ann Arbor, MI 48106.
Abstract
PURPOSE: The current manuscript reviews approaches for phenotyping central sensitization (CS). METHODS: The manuscript covers the concept of diagnostic phenotyping, use of endophenotypes, biomarkers, and symptom clusters. Specifically, the components of CS that include general sensory sensitivity (assessed by quantitative sensory testing) and a symptom cluster denoting sleep difficulties, pain, affect, cognitive difficulties, and low energy (S.P.A.C.E.). RESULTS: Each of the assessment domains are described with reference to CS and their presence in chronic overlapping pain conditions (COPCs) - conditions likely influenced by CS. CONCLUSIONS: COPCs likely represent clinical diagnostic phenotypes of CS. Components of CS can also be assessed using QST or self-report instruments designed to assess single elements of CS or more general composite indices.
PURPOSE: The current manuscript reviews approaches for phenotyping central sensitization (CS). METHODS: The manuscript covers the concept of diagnostic phenotyping, use of endophenotypes, biomarkers, and symptom clusters. Specifically, the components of CS that include general sensory sensitivity (assessed by quantitative sensory testing) and a symptom cluster denoting sleep difficulties, pain, affect, cognitive difficulties, and low energy (S.P.A.C.E.). RESULTS: Each of the assessment domains are described with reference to CS and their presence in chronic overlapping pain conditions (COPCs) - conditions likely influenced by CS. CONCLUSIONS: COPCs likely represent clinical diagnostic phenotypes of CS. Components of CS can also be assessed using QST or self-report instruments designed to assess single elements of CS or more general composite indices.
Authors: Louise Humphrey; Rob Arbuckle; Philip Mease; David A Williams; Bente Danneskiold Samsoe; Claire Gilbert Journal: BMC Musculoskelet Disord Date: 2010-09-20 Impact factor: 2.362
Authors: Benjamin Crettaz; Martin Marziniak; Peter Willeke; Peter Young; Dirk Hellhammer; Astrid Stumpf; Markus Burgmer Journal: PLoS One Date: 2013-08-07 Impact factor: 3.240
Authors: Lindsey C McKernan; Leslie J Crofford; Ahra Kim; Simon N Vandekar; William S Reynolds; Kathryn A Hansen; Daniel J Clauw; David A Williams Journal: Pain Med Date: 2021-10-08 Impact factor: 3.750
Authors: Chelsea M Kaplan; Andrew Schrepf; Ishtiaq Mawla; Eric Ichesco; Kevin F Boehnke; Adriene Beltz; Emily Foxen-Craft; Michael P Puglia; Alexandre Tsodikov; David A Williams; Afton L Hassett; Daniel J Clauw; Steven E Harte; Richard E Harris Journal: Pain Date: 2022-04-01 Impact factor: 7.926