| Literature DB >> 26468323 |
Kathryn Adamiak Davis1, Ravi Prakash Reddy Nanga2, Sandhitsu Das3, Stephanie H Chen1, Peter N Hadar1, John R Pollard1, Timothy H Lucas4, Russell T Shinohara5, Brian Litt1, Hari Hariharan2, Mark A Elliott2, John A Detre2, Ravinder Reddy2.
Abstract
When neuroimaging reveals a brain lesion, drug-resistant epilepsy patients show better outcomes after resective surgery than do the one-third of drug-resistant epilepsy patients who have normal brain magnetic resonance imaging (MRI). We applied a glutamate imaging method, GluCEST (glutamate chemical exchange saturation transfer), to patients with nonlesional temporal lobe epilepsy based on conventional MRI. GluCEST correctly lateralized the temporal lobe seizure focus on visual and quantitative analyses in all patients. MR spectra, available for a subset of patients and controls, corroborated the GluCEST findings. Hippocampal volumes were not significantly different between hemispheres. GluCEST allowed high-resolution functional imaging of brain glutamate and has potential to identify the epileptic focus in patients previously deemed nonlesional. This method may lead to improved clinical outcomes for temporal lobe epilepsy as well as other localization-related epilepsies.Entities:
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Year: 2015 PMID： 26468323 PMCID： PMC4710355 DOI： 10.1126/scitranslmed.aaa7095
Source DB: PubMed Journal: Sci Transl Med ISSN： 1946-6234 Impact factor: 17.956