Literature DB >> 26456990

Operation of the "Small" BioAMS Spectrometers at CAMS: Past and Future Prospects.

T J Ognibene1, K W Haack1, G Bench1, T A Brown1, K W Turteltaub2.   

Abstract

A summary of results from the solid samples run on our compact 1 MV AMS system over its 13.5 years of operation is presented. On average 7065 samples per year were measured with that average dropping to 3278 samples per year following the deployment of our liquid sample capability. Although the dynamic range of our spectrometer is 4.5 orders in magnitude, most of the measured graphitic samples had 14C/C concentrations between 0.1 and 1 modern. The measurements of our ANU sucrose standard followed a Gaussian distribution with an average of 1.5082 ± 0.0134 modern. The LLNL biomedical AMS program supported many different types of experiments, however, the large majority of samples measured were derived from animal model systems. We have transitioned all of our biomedical AMS measurements to the recently installed 250 kV SSAMS instrument with good agreement compared in measured 14C/C isotopic ratios between sample splits. Finally, we present results from replacement of argon stripping gas with helium in the SSAMS with a 22% improvement in ion transmission through the accelerator and high-energy analyzing magnet.

Entities:  

Keywords:  14C; SSAMS; accelerator mass spectrometry; biomedical AMS; graphite

Year:  2015        PMID: 26456990      PMCID: PMC4594839          DOI: 10.1016/j.nimb.2015.05.019

Source DB:  PubMed          Journal:  Nucl Instrum Methods Phys Res B        ISSN: 0168-583X            Impact factor:   1.377


  6 in total

1.  Ultrahigh efficiency moving wire combustion interface for online coupling of high-performance liquid chromatography (HPLC).

Authors:  Avi T Thomas; Ted Ognibene; Paul Daley; Ken Turteltaub; Harry Radousky; Graham Bench
Journal:  Anal Chem       Date:  2011-11-21       Impact factor: 6.986

2.  Directly coupled high-performance liquid chromatography-accelerator mass spectrometry measurement of chemically modified protein and peptides.

Authors:  Avi T Thomas; Benjamin J Stewart; Ted J Ognibene; Kenneth W Turteltaub; Graham Bench
Journal:  Anal Chem       Date:  2013-03-20       Impact factor: 6.986

Review 3.  Quantitating isotopic molecular labels with accelerator mass spectrometry.

Authors:  John S Vogel; Adam H Love
Journal:  Methods Enzymol       Date:  2005       Impact factor: 1.600

4.  A high-throughput method for the conversion of CO2 obtained from biochemical samples to graphite in septa-sealed vials for quantification of 14C via accelerator mass spectrometry.

Authors:  Ted J Ognibene; Graham Bench; John S Vogel; Graham F Peaslee; Steve Murov
Journal:  Anal Chem       Date:  2003-05-01       Impact factor: 6.986

5.  Bomb Pulse Biology.

Authors:  Miranda J Sarachine Falso; Bruce A Buchholz
Journal:  Nucl Instrum Methods Phys Res B       Date:  2012-09-15       Impact factor: 1.377

6.  Installation of hybrid ion source on the 1-MV LLNL BioAMS spectrometer.

Authors:  T J Ognibene; G A Salazar
Journal:  Nucl Instrum Methods Phys Res B       Date:  2011-11-28       Impact factor: 1.377

  6 in total
  4 in total

1.  Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing.

Authors:  Erin Madeen; Lisbeth K Siddens; Sandra Uesugi; Tammie McQuistan; Richard A Corley; Jordan Smith; Katrina M Waters; Susan C Tilton; Kim A Anderson; Ted Ognibene; Kenneth Turteltaub; David E Williams
Journal:  Toxicol Appl Pharmacol       Date:  2018-12-21       Impact factor: 4.219

2.  Trials and Tribulations in the First Three Years in Operation of the SSAMS for Biomedical 14C-AMS at LLNL.

Authors:  T J Ognibene; K W Haack; G Bench; K W Turteltaub
Journal:  Nucl Instrum Methods Phys Res B       Date:  2018-05-17       Impact factor: 1.377

3.  An Interface for the Direct Coupling of Small Liquid Samples to AMS.

Authors:  T J Ognibene; A T Thomas; P F Daley; G Bench; K W Turteltaub
Journal:  Nucl Instrum Methods Phys Res B       Date:  2015-05-28       Impact factor: 1.377

4.  Tracking Tumor Colonization in Xenograft Mouse Models Using Accelerator Mass Spectrometry.

Authors:  Nicholas R Hum; Kelly A Martin; Michael A Malfatti; Kurt Haack; Bruce A Buchholz; Gabriela G Loots
Journal:  Sci Rep       Date:  2018-10-09       Impact factor: 4.379

  4 in total

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