Literature DB >> 23467295

Installation of hybrid ion source on the 1-MV LLNL BioAMS spectrometer.

T J Ognibene1, G A Salazar.   

Abstract

A second ion source was recently installed onto the LLNL 1-MV AMS spectrometer, which is dedicated to the quantification of 14C and 3H within biochemical samples. This source is unique among the other LLNL cesium sputter ion sources in that it can ionize both gaseous and solid samples. Also, the injection beam line has been designed to directly measure 14C/12C isotope ratios without the need for electrostatic bouncing. Preliminary tests show that this source can ionize transient CO2 gas pulses containing less than 1 ug carbon with approximately 1.5% efficiency. We demonstrate that the measured 14C/12C isotope ratio is largely unaffected by small drifts in the argon stripper gas density. We also determine that a tandem accelerating voltage of 670 kV enables the highest 14C transmission through the system. Finally, we describe a series of performance tests using solid graphite targets spanning nearly 3 orders in magnitude dynamic range and compare the results to our other ion source.

Entities:  

Keywords:  AMS; CO2 gas; graphite; ion sources; moving-wire

Year:  2011        PMID: 23467295      PMCID: PMC3586325          DOI: 10.1016/j.nimb.2011.11.029

Source DB:  PubMed          Journal:  Nucl Instrum Methods Phys Res B        ISSN: 0168-583X            Impact factor:   1.377


  3 in total

1.  A high-throughput method for the conversion of CO2 obtained from biochemical samples to graphite in septa-sealed vials for quantification of 14C via accelerator mass spectrometry.

Authors:  Ted J Ognibene; Graham Bench; John S Vogel; Graham F Peaslee; Steve Murov
Journal:  Anal Chem       Date:  2003-05-01       Impact factor: 6.986

2.  Sample preparation for quantitation of tritium by accelerator mass spectrometry.

Authors:  Marina L Chiarappa-Zucca; Karen H Dingley; Mark L Roberts; Carol A Velsko; Adam H Love
Journal:  Anal Chem       Date:  2002-12-15       Impact factor: 6.986

3.  Installation of hybrid ion source on the 1-MV LLNL BioAMS spectrometer.

Authors:  T J Ognibene; G A Salazar
Journal:  Nucl Instrum Methods Phys Res B       Date:  2011-11-28       Impact factor: 1.377

  3 in total
  11 in total

1.  Human Microdosing with Carcinogenic Polycyclic Aromatic Hydrocarbons: In Vivo Pharmacokinetics of Dibenzo[def,p]chrysene and Metabolites by UPLC Accelerator Mass Spectrometry.

Authors:  Erin P Madeen; Ted J Ognibene; Richard A Corley; Tammie J McQuistan; Marilyn C Henderson; William M Baird; Graham Bench; Ken W Turteltaub; David E Williams
Journal:  Chem Res Toxicol       Date:  2016-09-09       Impact factor: 3.739

2.  Design of a secondary ionization target for direct production of a C- beam from CO2 pulses for online AMS.

Authors:  Gary Salazar; Ted Ognibene
Journal:  Nucl Instrum Methods Phys Res B       Date:  2013-01       Impact factor: 1.377

3.  Directly coupled high-performance liquid chromatography-accelerator mass spectrometry measurement of chemically modified protein and peptides.

Authors:  Avi T Thomas; Benjamin J Stewart; Ted J Ognibene; Kenneth W Turteltaub; Graham Bench
Journal:  Anal Chem       Date:  2013-03-20       Impact factor: 6.986

4.  Bomb Pulse Biology.

Authors:  Miranda J Sarachine Falso; Bruce A Buchholz
Journal:  Nucl Instrum Methods Phys Res B       Date:  2012-09-15       Impact factor: 1.377

5.  Trials and Tribulations in the First Three Years in Operation of the SSAMS for Biomedical 14C-AMS at LLNL.

Authors:  T J Ognibene; K W Haack; G Bench; K W Turteltaub
Journal:  Nucl Instrum Methods Phys Res B       Date:  2018-05-17       Impact factor: 1.377

6.  An Interface for the Direct Coupling of Small Liquid Samples to AMS.

Authors:  T J Ognibene; A T Thomas; P F Daley; G Bench; K W Turteltaub
Journal:  Nucl Instrum Methods Phys Res B       Date:  2015-05-28       Impact factor: 1.377

7.  Operation of the "Small" BioAMS Spectrometers at CAMS: Past and Future Prospects.

Authors:  T J Ognibene; K W Haack; G Bench; T A Brown; K W Turteltaub
Journal:  Nucl Instrum Methods Phys Res B       Date:  2015-05-26       Impact factor: 1.377

8.  Installation of hybrid ion source on the 1-MV LLNL BioAMS spectrometer.

Authors:  T J Ognibene; G A Salazar
Journal:  Nucl Instrum Methods Phys Res B       Date:  2011-11-28       Impact factor: 1.377

9.  Human in Vivo Pharmacokinetics of [(14)C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Microdosing.

Authors:  Erin Madeen; Richard A Corley; Susan Crowell; Kenneth Turteltaub; Ted Ognibene; Mike Malfatti; Tammie J McQuistan; Mary Garrard; Dan Sudakin; David E Williams
Journal:  Chem Res Toxicol       Date:  2014-12-10       Impact factor: 3.739

Review 10.  Opportunities in low-level radiocarbon microtracing: applications and new technology.

Authors:  Le Thuy Vuong; Qi Song; Hee Joo Lee; Ad F Roffel; Seok-Ho Shin; Young G Shin; Stephen R Dueker
Journal:  Future Sci OA       Date:  2015-12-23
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