Literature DB >> 22004428

Ultrahigh efficiency moving wire combustion interface for online coupling of high-performance liquid chromatography (HPLC).

Avi T Thomas1, Ted Ognibene, Paul Daley, Ken Turteltaub, Harry Radousky, Graham Bench.   

Abstract

We describe a 100%-efficient moving-wire interface (MWI) for online coupling of high-performance liquid chromatography (HPLC) that transmits 100% of the carbon in nonvolatile analytes to a CO(2)-gas-accepting ion source. This interface accepts a flow of analyte in solvent, evaporates the solvent, combusts the remaining analyte, and directs the combustion products to the instrument of choice. Effluent is transferred to a periodically indented wire by a coherent jet to increase efficiency and maintain peak resolution. The combustion oven is plumbed such that gaseous combustion products are completely directed to an exit capillary, avoiding the loss of combustion products to the atmosphere. This system achieves almost-complete transfer of the analyte at HPLC flow rates up to 125 μL/min at a wire speed of 6 cm/s. This represents a 30× increase in efficiency and an 8× increase in maximum wire loading, compared to the spray transfer technique used in earlier MWIs.

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Year:  2011        PMID： 22004428      PMCID： PMC3414258          DOI： 10.1021/ac202013s

Source DB:  PubMed          Journal:  Anal Chem        ISSN： 0003-2700            Impact factor:   6.986


  6 in total

1.  Mass spectrometer study of evaporation of alpha-amino acids.

Authors:  J S Gaffney; R C Pierce; L Friedman
Journal:  J Am Chem Soc       Date:  1977-06-22       Impact factor: 15.419

2.  High-precision continuous-flow isotope ratio mass spectrometry.

Authors:  J T Brenna; T N Corso; H J Tobias; R J Caimi
Journal:  Mass Spectrom Rev       Date:  1997 Sep-Oct       Impact factor: 10.946

3.  Moving-wire device for carbon isotopic analyses of nanogram quantities of nonvolatile organic carbon.

Authors:  Alex L Sessions; Sean P Sylva; John M Hayes
Journal:  Anal Chem       Date:  2005-10-15       Impact factor: 6.986

4.  A high-throughput method for the conversion of CO2 obtained from biochemical samples to graphite in septa-sealed vials for quantification of 14C via accelerator mass spectrometry.

Authors:  Ted J Ognibene; Graham Bench; John S Vogel; Graham F Peaslee; Steve Murov
Journal:  Anal Chem       Date:  2003-05-01       Impact factor: 6.986

Review 5.  Liquid chromatography combined with mass spectrometry for 13C isotopic analysis in life science research.

Authors:  Jean-Philippe Godin; Laurent-Bernard Fay; Gérard Hopfgartner
Journal:  Mass Spectrom Rev       Date:  2007 Nov-Dec       Impact factor: 10.946

6.  Drop formation in aqueous two-phase systems.

Authors:  R S Barhate; Ganapathi Patil; N D Srinivas; K S M S Raghavarao
Journal:  J Chromatogr A       Date:  2004-01-16       Impact factor: 4.759
  6 in total
  15 in total

1.  Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing.

Authors:  Erin Madeen; Lisbeth K Siddens; Sandra Uesugi; Tammie McQuistan; Richard A Corley; Jordan Smith; Katrina M Waters; Susan C Tilton; Kim A Anderson; Ted Ognibene; Kenneth Turteltaub; David E Williams
Journal:  Toxicol Appl Pharmacol       Date:  2018-12-21       Impact factor: 4.219

2.  Human Microdosing with Carcinogenic Polycyclic Aromatic Hydrocarbons: In Vivo Pharmacokinetics of Dibenzo[def,p]chrysene and Metabolites by UPLC Accelerator Mass Spectrometry.

Authors:  Erin P Madeen; Ted J Ognibene; Richard A Corley; Tammie J McQuistan; Marilyn C Henderson; William M Baird; Graham Bench; Ken W Turteltaub; David E Williams
Journal:  Chem Res Toxicol       Date:  2016-09-09       Impact factor: 3.739

3.  Towards Practical Endoscopic Mass Spectrometry.

Authors:  Lee Chuin Chen; Kentaro Yoshimura; Satoshi Ninomiya; Sen Takeda; Kenzo Hiraoka
Journal:  Mass Spectrom (Tokyo)       Date:  2017-08-23

4.  Pharmacokinetics of [14C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction.

Authors:  Jessica M Hummel; Erin P Madeen; Lisbeth K Siddens; Sandra L Uesugi; Tammie McQuistan; Kim A Anderson; Kenneth W Turteltaub; Ted J Ognibene; Graham Bench; Sharon K Krueger; Stuart Harris; Jordan Smith; Susan C Tilton; William M Baird; David E Williams
Journal:  Food Chem Toxicol       Date:  2018-03-05       Impact factor: 6.023

5.  Directly coupled high-performance liquid chromatography-accelerator mass spectrometry measurement of chemically modified protein and peptides.

Authors:  Avi T Thomas; Benjamin J Stewart; Ted J Ognibene; Kenneth W Turteltaub; Graham Bench
Journal:  Anal Chem       Date:  2013-03-20       Impact factor: 6.986

6.  Use of microdosing and accelerator mass spectrometry to evaluate the pharmacokinetic linearity of a novel tricyclic GyrB/ParE inhibitor in rats.

Authors:  Michael A Malfatti; Victoria Lao; Courtney L Ramos; Voon S Ong; Kenneth W Turteltaub
Journal:  Antimicrob Agents Chemother       Date:  2014-08-18       Impact factor: 5.191

Review 7.  Use of Accelerator Mass Spectrometry in Human Health and Molecular Toxicology.

Authors:  Heather A Enright; Michael A Malfatti; Maike Zimmermann; Ted Ognibene; Paul Henderson; Kenneth W Turteltaub
Journal:  Chem Res Toxicol       Date:  2016-10-11       Impact factor: 3.739

8.  Trials and Tribulations in the First Three Years in Operation of the SSAMS for Biomedical 14C-AMS at LLNL.

Authors:  T J Ognibene; K W Haack; G Bench; K W Turteltaub
Journal:  Nucl Instrum Methods Phys Res B       Date:  2018-05-17       Impact factor: 1.377

9.  An Interface for the Direct Coupling of Small Liquid Samples to AMS.

Authors:  T J Ognibene; A T Thomas; P F Daley; G Bench; K W Turteltaub
Journal:  Nucl Instrum Methods Phys Res B       Date:  2015-05-28       Impact factor: 1.377

10.  Operation of the "Small" BioAMS Spectrometers at CAMS: Past and Future Prospects.

Authors:  T J Ognibene; K W Haack; G Bench; T A Brown; K W Turteltaub
Journal:  Nucl Instrum Methods Phys Res B       Date:  2015-05-26       Impact factor: 1.377
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