Huagang Li1, Jing Wang2, Pu Wang3, Yan Rao4, Liping Chen5. 1. Department of Neurology, Zhongnan Hospital, Wuhan University, China. Electronic address: lihuagang2003@163.com. 2. Department of Neurology, Zhongnan Hospital, Wuhan University, China. 3. Department of Rehabilitation, West China Hospital, Sichuang University, China. 4. Animal Biosafety Level III Laboratory at the Center for Animal Experiment, Wuhan University, China. 5. Department of Gastroenterology, Zhongnan Hospital, Wuhan University, China.
Abstract
BACKGROUND: Dementia is the most prevalent neurological disease in aged people. Chronic cerebral hypoperfusion (CCH) is one of the causes of vascular dementia (VaD) and is also an etiological factor for Alzheimer's disease (AD). However, effective therapy for those two diseases is still missing. Resveratrol is a polyphenol produced by plants that have multiple biological functions, such as increased life span and delay in the onset of diseases associated with aging. It is known supplement with resveratrol could exert neuroprotection against multiple injury factors induced neuronal death and degeneration, as well as the cognitive decline of CCH rat model. METHODS: The morris water maze was used to evaluate the learning and memory, electrophysiological recording was used to detect the synaptic plasticity, the Golgi staining was used to examine the change of dendritic spines, the western blot was used to detect the proteins levels. RESULTS: We reported that resveratrol pretreatment effectively restore the synaptic plasticity in CCH rats both functional and structural. We also found that the PKA-CREB activation may be a major player in resveratrol-mediated neuroprotection in CCH model. CONCLUSIONS: Our data provide the mechanistic evidence for the neuroprotective effects of resveratrol in vascular dementia.
BACKGROUND: Dementia is the most prevalent neurological disease in aged people. Chronic cerebral hypoperfusion (CCH) is one of the causes of vascular dementia (VaD) and is also an etiological factor for Alzheimer's disease (AD). However, effective therapy for those two diseases is still missing. Resveratrol is a polyphenol produced by plants that have multiple biological functions, such as increased life span and delay in the onset of diseases associated with aging. It is known supplement with resveratrol could exert neuroprotection against multiple injury factors induced neuronal death and degeneration, as well as the cognitive decline of CCHrat model. METHODS: The morris water maze was used to evaluate the learning and memory, electrophysiological recording was used to detect the synaptic plasticity, the Golgi staining was used to examine the change of dendritic spines, the western blot was used to detect the proteins levels. RESULTS: We reported that resveratrol pretreatment effectively restore the synaptic plasticity in CCHrats both functional and structural. We also found that the PKA-CREB activation may be a major player in resveratrol-mediated neuroprotection in CCH model. CONCLUSIONS: Our data provide the mechanistic evidence for the neuroprotective effects of resveratrol in vascular dementia.