Literature DB >> 26993301

Resveratrol and Alzheimer's Disease: Mechanistic Insights.

Touqeer Ahmed1, Sehrish Javed2, Sana Javed2, Ameema Tariq2, Dunja Šamec3, Silvia Tejada4, Seyed Fazel Nabavi5, Nady Braidy6, Seyed Mohammad Nabavi7.   

Abstract

Alzheimer's disease (AD) is the leading cause of dementia in the elderly and is characterized by progressive cognitive and memory deficits. The pathological hallmarks of AD include extracellular senile plaques and intracellular neurofibrillary tangles. Although several mechanisms have been used to explain the underlying pathogenesis of AD, current treatment regimens remain inadequate. The neuroprotective effects of the polyphenolic stilbene resveratrol (3,5,4'-trihydroxy-trans-stilbene) have been investigated in several in vitro and in vivo models of AD. The current review discusses the multiple potential mechanisms of action of resveratrol on the pathobiology of AD. Moreover, due to the limited pharmacokinetic parameters of resveratrol, multiple strategies aimed at increasing the bioavailability of resveratrol have also been addressed.

Entities:  

Keywords:  Alzheimer’s disease; Amyloid; Neurodegeneration; Neuroinflammation; Resveratrol

Mesh：

Substances：

Year:  2016        PMID： 26993301     DOI： 10.1007/s12035-016-9839-9

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  145 in total

Review 1.  Alcohol in moderation, cardioprotection, and neuroprotection: epidemiological considerations and mechanistic studies.

Authors:  Michael A Collins; Edward J Neafsey; Kenneth J Mukamal; Mary O Gray; Dale A Parks; Dipak K Das; Ronald J Korthuis
Journal:  Alcohol Clin Exp Res       Date:  2008-11-19       Impact factor: 3.455

Review 2.  Autophagy dysfunction and its link to Alzheimer's disease and type II diabetes mellitus.

Authors:  Cornelia M Wilson; Amandine Magnaudeix; Catherine Yardin; Faraj Terro
Journal:  CNS Neurol Disord Drug Targets       Date:  2014-03       Impact factor: 4.388

Review 3.  Possible involvement of programmed cell death pathways in the neuroprotective action of polyphenols.

Authors:  S Bastianetto; S Krantic; J-G Chabot; R Quirion
Journal:  Curr Alzheimer Res       Date:  2011-08       Impact factor: 3.498

4.  Effect of alpha lipoic acid, melatonin and trans resveratrol on intracerebroventricular streptozotocin induced spatial memory deficit in rats.

Authors:  Monisha Sharma; Seema Briyal; Y K Gupta
Journal:  Indian J Physiol Pharmacol       Date:  2005 Oct-Dec

5.  Up-regulation of NF-kB-sensitive miRNA-125b and miRNA-146a in metal sulfate-stressed human astroglial (HAG) primary cell cultures.

Authors:  Aileen I Pogue; Maire E Percy; Jian-Guo Cui; Yuan Yuan Li; S Bhattacharjee; James M Hill; Theodore P A Kruck; Yuhai Zhao; Walter J Lukiw
Journal:  J Inorg Biochem       Date:  2011-05-27       Impact factor: 4.155

6.  Characterization of phenolic profiles of Northern European berries by capillary electrophoresis and determination of their antioxidant activity.

Authors:  Sille Ehala; Merike Vaher; Mihkel Kaljurand
Journal:  J Agric Food Chem       Date:  2005-08-10       Impact factor: 5.279

Review 7.  Resveratrol bioavailability and toxicity in humans.

Authors:  Charles-Henry Cottart; Valérie Nivet-Antoine; Christelle Laguillier-Morizot; Jean-Louis Beaudeux
Journal:  Mol Nutr Food Res       Date:  2010-01       Impact factor: 5.914

8.  Resveratrol reduces glutamate-mediated monocyte chemotactic protein-1 expression via inhibition of extracellular signal-regulated kinase 1/2 pathway in rat hippocampal slice cultures.

Authors:  Eun Ok Lee; Hee Ju Park; Jihee Lee Kang; Hye-Sun Kim; Young Hae Chong
Journal:  J Neurochem       Date:  2009-12-28       Impact factor: 5.372

9.  Proenergetic effects of resveratrol in the murine neuronal cell line Neuro2a.

Authors:  Nhu T Q Nguyen; Lezanne Ooi; Sabine C Piller; Gerald Münch
Journal:  Mol Nutr Food Res       Date:  2013-08-12       Impact factor: 5.914

10.  Neuroprotective effects of resveratrol and epigallocatechin gallate polyphenols are mediated by the activation of protein kinase C gamma.

Authors:  Caroline Menard; Stéphane Bastianetto; Rémi Quirion
Journal:  Front Cell Neurosci       Date:  2013-12-26       Impact factor: 5.505
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  43 in total

1.  A theoretical exploration of the intermolecular interactions between resveratrol and water: a DFT and AIM analysis.

Authors:  A Suvitha; N S Venkataramanan; R Sahara; Y Kawazoe
Journal:  J Mol Model       Date:  2019-02-08       Impact factor: 1.810

2.  Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement.

Authors:  Rubén Corpas; Christian Griñán-Ferré; Eduard Rodríguez-Farré; Mercè Pallàs; Coral Sanfeliu
Journal:  Mol Neurobiol       Date:  2018-06-13       Impact factor: 5.590

Review 3.  Resveratrol for Alzheimer's disease.

Authors:  Christine Sawda; Charbel Moussa; R Scott Turner
Journal:  Ann N Y Acad Sci       Date:  2017-08-16       Impact factor: 5.691

4.  The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans.

Authors:  Nadine Fischer; Christian Büchter; Karoline Koch; Sabrina Albert; René Csuk; Wim Wätjen
Journal:  J Pharm Pharmacol       Date:  2016-11-23       Impact factor: 3.765

5.  Tannic Acid Ameliorates STZ-Induced Alzheimer's Disease-Like Impairment of Memory, Neuroinflammation, Neuronal Death and Modulates Akt Expression.

Authors:  Mariana F B Gerzson; Natália P Bona; Mayara S P Soares; Fernanda C Teixeira; Francine L Rahmeier; Fabiano B Carvalho; Marilda da Cruz Fernandes; Giovana Onzi; Guido Lenz; Relber A Gonçales; Roselia M Spanevello; Francieli M Stefanello
Journal:  Neurotox Res       Date:  2020-01-29       Impact factor: 3.911

6.  Resveratrol protects the brain against oxidative damage in a dopaminergic animal model of mania.

Authors:  Samira Menegas; Camila L Ferreira; José Henrique Cararo; Fernanda F Gava; Gustavo C Dal-Pont; Maria L Gomes; Jotele F Agostini; Patrícia Fernanda Schuck; Giselli Scaini; Monica L Andersen; João Quevedo; Samira S Valvassori
Journal:  Metab Brain Dis       Date:  2019-03-27       Impact factor: 3.584

Review 7.  Resveratrol and neuroprotection: an insight into prospective therapeutic approaches against Alzheimer's disease from bench to bedside.

Authors:  Fahadul Islam; Mohamed H Nafady; Md Rezaul Islam; Susmita Saha; Salma Rashid; Aklima Akter; Md Harun- Or-Rashid; Muhammad Furqan Akhtar; Asma Perveen; Ghulam Md Ashraf; Md Habibur Rahman; Sherouk Hussein Sweilam
Journal:  Mol Neurobiol       Date:  2022-05-12       Impact factor: 5.590

Review 8.  Mediterranean Diet in Preventing Neurodegenerative Diseases.

Authors:  Hannah Gardener; Michelle R Caunca
Journal:  Curr Nutr Rep       Date:  2018-03

9.  Inhibition of the Nrf2/HO-1 Axis Suppresses the Mitochondria-Related Protection Promoted by Gastrodin in Human Neuroblastoma Cells Exposed to Paraquat.

Authors:  Marcos Roberto de Oliveira; Flávia de Bittencourt Brasil; Cristina Ribas Fürstenau
Journal:  Mol Neurobiol       Date:  2018-07-11       Impact factor: 5.590

Review 10.  The potential role of Keap1-Nrf2 pathway in the pathogenesis of Alzheimer's disease, type 2 diabetes, and type 2 diabetes-related Alzheimer's disease.

Authors:  Ling He; Yi Sun
Journal:  Metab Brain Dis       Date:  2021-06-15       Impact factor: 3.584
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