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Literature DB >> 28971348

Cerebral Hypoperfusion and Other Shared Brain Pathologies in Ischemic Stroke and Alzheimer's Disease.

Shuying Dong^1,2, Shelly Maniar^2,3, Mioara D Manole⁴, Dandan Sun^5,6.

Abstract

Newly emerged evidence reveals that ischemic stroke and Alzheimer's disease (AD) share pathophysiological changes in brain tissue including hypoperfusion, oxidative stress, immune exhaustion, and inflammation. A mechanistic link between hypoperfusion and amyloid β accumulation can lead to cell damage as well as to motor and cognitive deficits. This review will discuss decreased cerebral perfusion and other related pathophysiological changes common to both ischemic stroke and AD, such as vascular damages, cerebral blood flow alteration, abnormal expression of amyloid β and tau proteins, as well as behavioral and cognitive deficits. Furthermore, this review highlights current treatment options and potential therapeutic targets that warrant further investigation.

Entities: Chemical

Keywords: Alzheimer’s disease; Amyloid β; Cerebral blood flow; Hypoperfusion; Stroke; Tau protein; Treatment

Mesh：

Substances：

Year: 2017 PMID： 28971348 DOI： 10.1007/s12975-017-0570-2

Source DB: PubMed Journal: Transl Stroke Res ISSN： 1868-4483 Impact factor: 6.800

98 in total

Review 1. Vascular cognitive impairment and Alzheimer's disease: role of cerebral hypoperfusion and oxidative stress.

Authors: Hyun Ah Kim; Alyson A Miller; Grant R Drummond; Amanda G Thrift; Thiruma V Arumugam; Thanh G Phan; Velandai K Srikanth; Christopher G Sobey
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Authors: Pauline Maillard; Owen Carmichael; Evan Fletcher; Bruce Reed; Dan Mungas; Charles DeCarli
Journal: Neurology Date: 2012-07-18 Impact factor: 9.910

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Authors: Xiao-Yi Xiong; Liang Liu; Qing-Wu Yang
Journal: Prog Neurobiol Date: 2016-05-07 Impact factor: 11.685

4. Risk factors for incident dementia after stroke and transient ischemic attack.

Authors: Jie Yang; Adrian Wong; Zhaolu Wang; Wenyan Liu; Lisa Au; Yunyun Xiong; Winnie W C Chu; Eric Y L Leung; Sirong Chen; Christine Lau; Anne Y Y Chan; Alexander Y L Lau; Florence Fan; Vincent Ip; Yannie Soo; Thomas Leung; Chi L Ho; Lawrence K S Wong; Vincent C T Mok
Journal: Alzheimers Dement Date: 2014-03-03 Impact factor: 21.566

Review 5. The role of cerebral ischemia in Alzheimer's disease.

Authors: R N Kalaria
Journal: Neurobiol Aging Date: 2000 Mar-Apr Impact factor: 4.673

6. Expression of Tau protein in rats with cognitive dysfunction induced by cerebral hypoperfusion.

Authors: Ji-Feng Li; Zhou Wang; Qin-Jian Sun; Yi-Feng Du
Journal: Int J Clin Exp Med Date: 2015-10-15

7. Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke.

Authors: Jennifer L Au; Nina Weishaupt; Hayley J Nell; Shawn N Whitehead; David F Cechetto
Journal: J Vis Exp Date: 2016-03-22 Impact factor: 1.355

Review 8. The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease.

Authors: Myles R Minter; Juliet M Taylor; Peter J Crack
Journal: J Neurochem Date: 2015-11-18 Impact factor: 5.372

9. Alzheimer disease and risk of stroke: a population-based cohort study.

Authors: Nai-Fang Chi; Li-Nien Chien; Hsiao-Lun Ku; Chaur-Jong Hu; Hung-Yi Chiou
Journal: Neurology Date: 2013-01-09 Impact factor: 9.910

Review 10. Capillary dysfunction: its detection and causative role in dementias and stroke.

Authors: Leif Østergaard; Sune Nørhøj Jespersen; Thorbjørn Engedahl; Eugenio Gutiérrez Jiménez; Mahmoud Ashkanian; Mikkel Bo Hansen; Simon Eskildsen; Kim Mouridsen
Journal: Curr Neurol Neurosci Rep Date: 2015-06 Impact factor: 5.081

13 in total

1. The Protein Modification and Degradation Pathways after Brain Ischemia.

Authors: Tibor Kristian; Bingren Hu
Journal: Transl Stroke Res Date: 2017-10-01 Impact factor: 6.829

2. Neuroprotective Effects of Theobromine in permanent bilateral common carotid artery occlusion rat model of cerebral hypoperfusion.

Authors: Javeed Ahmad Bhat; Manish Kumar
Journal: Metab Brain Dis Date: 2022-05-19 Impact factor: 3.655

3. Chronic cerebral hypoperfusion and blood-brain barrier disruption in uninjured brain areas of rhesus monkeys subjected to transient ischemic stroke.

Authors: Yingqian Zhang; Bangcheng Zhao; Qi Lai; Qinxi Li; Xun Tang; Yinbing Zhang; Zhixiang Pan; Qiang Gao; Zhihui Zhong
Journal: J Cereb Blood Flow Metab Date: 2022-02-09 Impact factor: 6.960

4. Effects of Lifestyle Factors on Cognitive Resilience: Commentary on "What This Sunny, Religious Town in California Teaches Us About Living Longer".

Authors: Prativa Sherchan; Fayth Miles; Michael Orlich; Gary Fraser; John H Zhang; Konrad Talbot; Penelope J Duerksen-Hughes
Journal: Transl Stroke Res Date: 2020-02-15 Impact factor: 6.829

5. Shared genes between Alzheimer's disease and ischemic stroke.

Authors: Chang-Juan Wei; Pan Cui; He Li; Wen-Jing Lang; Gui-You Liu; Xiao-Feng Ma
Journal: CNS Neurosci Ther Date: 2019-03-11 Impact factor: 5.243

Review 6. Emerging Clues of Regulatory Roles of Circular RNAs through Modulating Oxidative Stress: Focus on Neurological and Vascular Diseases.

Authors: Lingfei Li; Zhumei Ni; Xiaoli Si; Lin Jiang; Hongfei Sang; Wenqing Xia; Zhenzhen Chen; Jinyu Huang; Jingfen Jin; Anwen Shao; Congguo Yin
Journal: Oxid Med Cell Longev Date: 2021-03-01 Impact factor: 6.543

Review 10. The Role of Oxidative Stress in Common Risk Factors and Mechanisms of Cardio-Cerebrovascular Ischemia and Depression.

Authors: Danfeng Lin; Lingling Wang; Shenqiang Yan; Qing Zhang; John H Zhang; Anwen Shao
Journal: Oxid Med Cell Longev Date: 2019-11-15 Impact factor: 6.543