Literature DB >> 26451350

Synthesis of Some Benzimidazole Derivatives Bearing 1,3,4-Oxadiazole Moiety as Anticancer Agents.

Bereket Mochona1, Elizabeth Mazzio2, Madhavei Gangapurum2, Nelly Mateeva1, K K Redda2.   

Abstract

In an effort to establish new benzimidazole related structural leads with improved anticancer activity, several new benzimidazole derivatives (5a-i) with 1,3,4-oxadiazole scaffold incorporated were synthesized and studied for their anticancer activity. The anticancer screening against MDA-MB-231 breast cancer cell lines showed that compound (5c) exhibited moderate cytotoxicity.

Entities:  

Keywords:  1, 3, 4-Oxadizole; Benzimidazole; Cytotoxcity; Pharmacophore hybridization

Year:  2015        PMID： 26451350      PMCID： PMC4594831          DOI： 10.7598/cst2015.1029

Source DB:  PubMed          Journal:  Chem Sci Trans        ISSN： 2278-3318


  9 in total

1.  Synthesis, physicochemical properties and antimicrobial activity of some new benzimidazole derivatives.

Authors:  K F Ansari; C Lal
Journal:  Eur J Med Chem       Date:  2009-05-05       Impact factor: 6.514

2.  Novel benzimidazole-pyrimidine conjugates as potent antitumor agents.

Authors:  Heba T Abdel-Mohsen; Fatma A F Ragab; Mostafa M Ramla; Hoda I El Diwani
Journal:  Eur J Med Chem       Date:  2010-02-13       Impact factor: 6.514

3.  The new era of 1,2,4-oxadiazoles.

Authors:  Andrea Pace; Paola Pierro
Journal:  Org Biomol Chem       Date:  2009-09-16       Impact factor: 3.876

Review 4.  The therapeutic journey of benzimidazoles: a review.

Authors:  Yogita Bansal; Om Silakari
Journal:  Bioorg Med Chem       Date:  2012-09-17       Impact factor: 3.641

Review 5.  Recent updates on biological activities of oxadiazoles.

Authors:  Rikta Saha; Omprakash Tanwar; Akranth Marella; M Mumtaz Alam; Mymoona Akhter
Journal:  Mini Rev Med Chem       Date:  2013-06       Impact factor: 3.862

6.  Design, synthesis and antimicrobial activities of some azole derivatives.

Authors:  Serap Basoglu; Meltem Yolal; Serpil Demirci; Neslihan Demirbas; Hakan Bektas; Sengul Alpay Karaoglu
Journal:  Acta Pol Pharm       Date:  2013 Mar-Apr       Impact factor: 0.330

7.  Benzimidazole clubbed with triazolo-thiadiazoles and triazolo-thiadiazines: new anticancer agents.

Authors:  Asif Husain; Mohd Rashid; M Shaharyar; Anees A Siddiqui; Ravinesh Mishra
Journal:  Eur J Med Chem       Date:  2012-07-16       Impact factor: 6.514

Review 8.  1,3,4-oxadiazole derivatives as potential biological agents.

Authors:  Juan Sun; Jigar A Makawana; Hai-Liang Zhu
Journal:  Mini Rev Med Chem       Date:  2013-10       Impact factor: 3.862

Review 9.  Synthetic approaches and pharmacological activity of 1,3,4-oxadiazoles: a review of the literature from 2000-2012.

Authors:  Cledualdo Soares de Oliveira; Bruno Freitas Lira; José Maria Barbosa-Filho; Jorge Gonçalo Fernandez Lorenzo; Petrônio Filgueiras de Athayde-Filho
Journal:  Molecules       Date:  2012-08-27       Impact factor: 4.411
  9 in total
  2 in total

1.  Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way.

Authors:  Ai-Jun Ding; Gui-Sheng Wu; Bin Tang; Xuechuan Hong; Michael X Zhu; Huai-Rong Luo
Journal:  Mol Cell Biochem       Date:  2016-11-16       Impact factor: 3.396

2.  Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole- 1,3,4-oxadiazole derivatives as human topoisomerase types I poison.

Authors:  Ulviye Acar Çevik; Begüm Nurpelin Sağlık; Derya Osmaniye; Serkan Levent; Betül Kaya Çavuşoğlu; Abdullah Burak Karaduman; Özlem Atlıd; Özlem Atlı Eklioğlu; Zafer Asım Kaplancıklı
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051
  2 in total

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