Bereket Mochona1, Elizabeth Mazzio2, Madhavei Gangapurum2, Nelly Mateeva1, K K Redda2. 1. College of Science and Technology, Department of Chemistry, Florida A&M University, Tallahassee, FL 32307, USA. 2. College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA.
Abstract
In an effort to establish new benzimidazole related structural leads with improved anticancer activity, several new benzimidazole derivatives (5a-i) with 1,3,4-oxadiazole scaffold incorporated were synthesized and studied for their anticancer activity. The anticancer screening against MDA-MB-231 breast cancer cell lines showed that compound (5c) exhibited moderate cytotoxicity.
In an effort to establish new benzimidazole related structural leads with improved anticancer activity, several new n class="Chemical">benzimidazole derivatives (5a-i) with 1,3,4-oxadiazole scaffold incorporated were synthesized and studied for their anticancer activity. The anticancer screening against MDA-MB-231breast cancer cell lines showed that compound (5c) exhibited moderate cytotoxicity.