Literature DB >> 20356655

Novel benzimidazole-pyrimidine conjugates as potent antitumor agents.

Heba T Abdel-Mohsen1, Fatma A F Ragab, Mostafa M Ramla, Hoda I El Diwani.   

Abstract

As a continuation to our previous work in synthesizing antitumor benzimidazoles, a series of 2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-(substituted)-6-phenylpyrimidine-5-carbonitriles was synthesized. Evaluation of the synthesized compounds for their in vitro cytotoxic activity against twelve cell lines namely, Cervical carcinoma (KB), Ovarial carcinoma (SK OV-3), CNS cancer (SF-268), Non small lung cancer (NCI H460), Colonadenocarcinoma (RKOP27), Leukaemia (HL60, U937, K562), Melanoma (G361, SK-MEL-28) and Neuroblastoma (GOTO, NB-1) revealed their marked potency when compared with known anticancer drugs. Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20356655     DOI： 10.1016/j.ejmech.2010.02.011

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  12 in total

1.  The periodic table of urea derivative: small molecules of zinc(II) and nickel(II) of diverse antimicrobial and antiproliferative applications.

Authors:  Christina N Banti; Mehmet Poyraz; I Sainis; Musa Sari; G Rossos; N Kourkoumelis; Sotiris K Hadjikakou
Journal:  Mol Divers       Date:  2019-02-23       Impact factor: 2.943

2.  Synthesis of Some Benzimidazole Derivatives Bearing 1,3,4-Oxadiazole Moiety as Anticancer Agents.

Authors:  Bereket Mochona; Elizabeth Mazzio; Madhavei Gangapurum; Nelly Mateeva; K K Redda
Journal:  Chem Sci Trans       Date:  2015-04

Review 3.  Imidazoles as potential anticancer agents.

Authors:  Imran Ali; Mohammad Nadeem Lone; Haasan Y Aboul-Enein
Journal:  Medchemcomm       Date:  2017-04-13       Impact factor: 3.597

4.  Synthesis, characterization, and pharmacological evaluation of novel azolo- and azinothiazinones containing 2,4-dihydroxyphenyl substituent as anticancer agents.

Authors:  Joanna Matysiak; Małgorzata Juszczak; Monika M Karpińska; Ewa Langner; Katarzyna Walczak; Marta Lemieszek; Alicja Skrzypek; Wojciech Rzeski; Andrzej Niewiadomy
Journal:  Monatsh Chem       Date:  2015-04-02       Impact factor: 1.451

5.  New (3-(1H-benzo[d]imidazol-2-yl))/(3-(3H-imidazo[4,5-b]pyridin-2-yl))-(1H-indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates as tubulin polymerization inhibitors.

Authors:  Kishore Mullagiri; V Lakshma Nayak; Satish Sunkari; Geeta Sai Mani; Sravanthi Devi Guggilapu; Burri Nagaraju; Abdullah Alarifi; Ahmed Kamal
Journal:  Medchemcomm       Date:  2017-12-12       Impact factor: 3.597

6.  Synthesis and Antiproliferative Activities of Benzimidazole-Based Sulfide and Sulfoxide Derivatives.

Authors:  Samir T Gaballah; Ahmed O H El-Nezhawy; Hassan Amer; Mamdouh Moawad Ali; Abeer Essam El-Din Mahmoud; Andreas Hofinger-Horvath
Journal:  Sci Pharm       Date:  2015-08-18

7.  Theoretical calculations of molecular descriptors for anticancer activities of 1, 2, 3-triazole-pyrimidine derivatives against gastric cancer cell line (MGC-803): DFT, QSAR and docking approaches.

Authors:  Rhoda Oyeladun Oyewole; Abel Kolawole Oyebamiji; Banjo Semire
Journal:  Heliyon       Date:  2020-05-21

8.  Synthesis and bioactivity evaluation of new 6-aryl-5-cyano thiouracils as potential antimicrobial and anticancer agents.

Authors:  Azza Taher Taher; Sahar Mahmoud Abou-Seri
Journal:  Molecules       Date:  2012-08-17       Impact factor: 4.411

9.  An efficient three-component, one-pot synthesis of 2-alkylthio-4-amino-5-cyano-6-aryl(alkyl)pyrimidines in water.

Authors:  Qiao-Yan Li; Ze-Mei Ge; Tie-Ming Cheng; Run-Tao Li
Journal:  Mol Divers       Date:  2012-06-28       Impact factor: 2.943

10.  One-Pot Synthesis of Benzo[4,5]imidazo[1,2-a]pyrimidin-2-ones Using a Hybrid Catalyst Supported on Magnetic Nanoparticles in Green Solvents.

Authors:  Alkassoume Moussa; Abbas Rahmati
Journal:  ChemistryOpen       Date:  2021-08       Impact factor: 2.630
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.