Literature DB >> 26450575

No time to waste--the ethical challenges created by CRISPR: CRISPR/Cas, being an efficient, simple, and cheap technology to edit the genome of any organism, raises many ethical and regulatory issues beyond the use to manipulate human germ line cells.

Arthur L Caplan1, Brendan Parent1, Michael Shen2, Carolyn Plunkett3.   

Abstract

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Year:  2015        PMID： 26450575      PMCID： PMC4641494          DOI： 10.15252/embr.201541337

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


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  7 in total

1.  Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.

Authors:  Bernd Zetsche; Jonathan S Gootenberg; Omar O Abudayyeh; Ian M Slaymaker; Kira S Makarova; Patrick Essletzbichler; Sara E Volz; Julia Joung; John van der Oost; Aviv Regev; Eugene V Koonin; Feng Zhang
Journal:  Cell       Date:  2015-09-25       Impact factor: 41.582

2.  Don't edit the human germ line.

Authors:  Edward Lanphier; Fyodor Urnov; Sarah Ehlen Haecker; Michael Werner; Joanna Smolenski
Journal:  Nature       Date:  2015-03-26       Impact factor: 49.962

3.  CRISPR, the disruptor.

Authors:  Heidi Ledford
Journal:  Nature       Date:  2015-06-04       Impact factor: 49.962

Review 4.  Genome editing. The new frontier of genome engineering with CRISPR-Cas9.

Authors:  Jennifer A Doudna; Emmanuelle Charpentier
Journal:  Science       Date:  2014-11-28       Impact factor: 47.728

5.  Ethics and germline gene editing.

Authors:  Jeremy Sugarman
Journal:  EMBO Rep       Date:  2015-07-02       Impact factor: 8.807

6.  Biotechnology. Regulating gene drives.

Authors:  Kenneth A Oye; Kevin Esvelt; Evan Appleton; Flaminia Catteruccia; George Church; Todd Kuiken; Shlomiya Bar-Yam Lightfoot; Julie McNamara; Andrea Smidler; James P Collins
Journal:  Science       Date:  2014-07-17       Impact factor: 47.728

Review 7.  Concerning RNA-guided gene drives for the alteration of wild populations.

Authors:  Kevin M Esvelt; Andrea L Smidler; Flaminia Catteruccia; George M Church
Journal:  Elife       Date:  2014-07-17       Impact factor: 8.140
  7 in total
  26 in total

1.  Carl Woese's worries about the role of bio-engineering.

Authors:  Min-Liang Wong
Journal:  EMBO Rep       Date:  2016-02-05       Impact factor: 8.807

2.  The ethics of genome editing in non-human animals: a systematic review of reasons reported in the academic literature.

Authors:  Nienke de Graeff; Karin R Jongsma; Josephine Johnston; Sarah Hartley; Annelien L Bredenoord
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2019-05-13       Impact factor: 6.237

3.  Ethical lessons from a tale of two genetically modified insects.

Authors:  Carolyn P Neuhaus; Arthur L Caplan
Journal:  Nat Biotechnol       Date:  2017-08-08       Impact factor: 54.908

Review 4.  CRISPR-Cas9: From a bacterial immune system to genome-edited human cells in clinical trials.

Authors:  Leonhard Kick; Marion Kirchner; Sabine Schneider
Journal:  Bioengineered       Date:  2017-03-13       Impact factor: 3.269

Review 5.  CRISPR-Cas System: History and Prospects as a Genome Editing Tool in Microorganisms.

Authors:  Muhammad R Javed; Maria Sadaf; Temoor Ahmed; Amna Jamil; Marium Nawaz; Hira Abbas; Anam Ijaz
Journal:  Curr Microbiol       Date:  2018-08-04       Impact factor: 2.188

Review 6.  Application of the genome editing tool CRISPR/Cas9 in non-human primates.

Authors:  Xin Luo; Min Li; Bing Su
Journal:  Dongwuxue Yanjiu       Date:  2016-07-18

7.  Unethical work must be filtered out or flagged.

Authors:  Graeme D Ruxton; Tom Mulder
Journal:  Nature       Date:  2019-08       Impact factor: 49.962

Review 8.  CRISPR-Cas and Its Wide-Ranging Applications: From Human Genome Editing to Environmental Implications, Technical Limitations, Hazards and Bioethical Issues.

Authors:  Roberto Piergentili; Alessandro Del Rio; Fabrizio Signore; Federica Umani Ronchi; Enrico Marinelli; Simona Zaami
Journal:  Cells       Date:  2021-04-21       Impact factor: 7.666

Review 9.  CRISPR-Based Genome Editing as a New Therapeutic Tool in Retinal Diseases.

Authors:  Seyed Ahmad Rasoulinejad; Faezeh Maroufi
Journal:  Mol Biotechnol       Date:  2021-05-31       Impact factor: 2.695

Review 10.  Science and Bioethics of CRISPR-Cas9 Gene Editing: An Analysis Towards Separating Facts and Fiction.

Authors:  Adam P Cribbs; Sumeth M W Perera
Journal:  Yale J Biol Med       Date:  2017-12-19
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