Literature DB >> 25810189

Don't edit the human germ line.

Edward Lanphier, Fyodor Urnov, Sarah Ehlen Haecker, Michael Werner, Joanna Smolenski.   

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Year:  2015        PMID： 25810189     DOI： 10.1038/519410a

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


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  6 in total

Review 1.  Genome editing with engineered zinc finger nucleases.

Authors:  Fyodor D Urnov; Edward J Rebar; Michael C Holmes; H Steve Zhang; Philip D Gregory
Journal:  Nat Rev Genet       Date:  2010-09       Impact factor: 53.242

Review 2.  Genome engineering with targetable nucleases.

Authors:  Dana Carroll
Journal:  Annu Rev Biochem       Date:  2014-03-03       Impact factor: 23.643

3.  Knockout rats via embryo microinjection of zinc-finger nucleases.

Authors:  Aron M Geurts; Gregory J Cost; Yevgeniy Freyvert; Bryan Zeitler; Jeffrey C Miller; Vivian M Choi; Shirin S Jenkins; Adam Wood; Xiaoxia Cui; Xiangdong Meng; Anna Vincent; Stephen Lam; Mieczyslaw Michalkiewicz; Rebecca Schilling; Jamie Foeckler; Shawn Kalloway; Hartmut Weiler; Séverine Ménoret; Ignacio Anegon; Gregory D Davis; Lei Zhang; Edward J Rebar; Philip D Gregory; Fyodor D Urnov; Howard J Jacob; Roland Buelow
Journal:  Science       Date:  2009-07-24       Impact factor: 47.728

4.  Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV.

Authors:  Pablo Tebas; David Stein; Winson W Tang; Ian Frank; Shelley Q Wang; Gary Lee; S Kaye Spratt; Richard T Surosky; Martin A Giedlin; Geoff Nichol; Michael C Holmes; Philip D Gregory; Dale G Ando; Michael Kalos; Ronald G Collman; Gwendolyn Binder-Scholl; Gabriela Plesa; Wei-Ting Hwang; Bruce L Levine; Carl H June
Journal:  N Engl J Med       Date:  2014-03-06       Impact factor: 91.245

5.  CRISPR/Cas9 nuclease-mediated gene knock-in in bovine-induced pluripotent cells.

Authors:  Young Tae Heo; Xiaoyuan Quan; Yong Nan Xu; Soonbong Baek; Hwan Choi; Nam-Hyung Kim; Jongpil Kim
Journal:  Stem Cells Dev       Date:  2014-11-03       Impact factor: 3.272

6.  Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR-Cas platform.

Authors:  K Yoshimi; T Kaneko; B Voigt; T Mashimo
Journal:  Nat Commun       Date:  2014-06-26       Impact factor: 14.919
  6 in total
  105 in total

Review 1.  Human Germline Genome Editing.

Authors:  Kelly E Ormond; Douglas P Mortlock; Derek T Scholes; Yvonne Bombard; Lawrence C Brody; W Andrew Faucett; Nanibaa' A Garrison; Laura Hercher; Rosario Isasi; Anna Middleton; Kiran Musunuru; Daniel Shriner; Alice Virani; Caroline E Young
Journal:  Am J Hum Genet       Date:  2017-08-03       Impact factor: 11.025

Review 2.  A Reminiscence about Early Times of Vitreous Water in Electron Cryomicroscopy.

Authors:  Jacques Dubochet
Journal:  Biophys J       Date:  2015-09-08       Impact factor: 4.033

Review 3.  [Gene therapy as a treatment concept for inherited retinal diseases].

Authors:  J-S Bellingrath; M D Fischer
Journal:  Ophthalmologe       Date:  2015-09       Impact factor: 1.059

4.  Gene Editing and Germ-line Intervention: The Need for Novel Responses to Novel Technologies.

Authors:  Courtney Addison; Samuel Taylor-Alexander
Journal:  Mol Ther       Date:  2015-11       Impact factor: 11.454

5.  Genome-editing revolution: My whirlwind year with CRISPR.

Authors:  Jennifer Doudna
Journal:  Nature       Date:  2015-12-24       Impact factor: 49.962

6.  No time to waste on the road to a liberal eugenics?

Authors:  Guenther Witzany
Journal:  EMBO Rep       Date:  2016-02-05       Impact factor: 8.807

7.  No time to waste--the ethical challenges created by CRISPR: CRISPR/Cas, being an efficient, simple, and cheap technology to edit the genome of any organism, raises many ethical and regulatory issues beyond the use to manipulate human germ line cells.

Authors:  Arthur L Caplan; Brendan Parent; Michael Shen; Carolyn Plunkett
Journal:  EMBO Rep       Date:  2015-10-08       Impact factor: 8.807

8.  Recommended Ethical Safeguards on Fertilization of Human Germ Cells Derived from Pluripotent Stem Cells Solely for Research Purposes.

Authors:  Hiroshi Mizuno
Journal:  Stem Cell Rev Rep       Date:  2016-08       Impact factor: 5.739

9.  Will CRISPR Germline Engineering Close the Door to an Open Future?

Authors:  Rachel L Mintz; John D Loike; Ruth L Fischbach
Journal:  Sci Eng Ethics       Date:  2018-10-24       Impact factor: 3.525

10.  Human Genome Editing and Ethical Considerations.

Authors:  Kewal Krishan; Tanuj Kanchan; Bahadur Singh
Journal:  Sci Eng Ethics       Date:  2015-07-08       Impact factor: 3.525
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