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Literature DB >> 28287876

CRISPR-Cas9: From a bacterial immune system to genome-edited human cells in clinical trials.

Leonhard Kick¹, Marion Kirchner¹, Sabine Schneider¹.

Abstract

The adaptive bacterial immune system CRISPR-Cas is revolutionizing all fields of life science and has opened up new frontiers toward personalised medicine. Since the elucidation of the molecular mechanism of Cas9 from Streptococcus pyogenes in 2012 and its development as a genomic engineering tool, genetic modifications in more than 40 species have been performed, over 290 patents have been filed worldwide and the first clinical trials using CRISPR-Cas-modified T-cells have recently been started in China and in the US. In this review we summarise current design developments, novel Cas systems and their antagonists, present and potential future applications as well as the ongoing debate on ethical issues, which has arisen through the CRISPR-Cas technology.

Entities: Species

Keywords: CRISPR-Cas; bacterial immune system; clinical trials; genome editing

Mesh：

Year: 2017 PMID： 28287876 PMCID： PMC5470512 DOI： 10.1080/21655979.2017.1299834

Source DB: PubMed Journal: Bioengineered ISSN： 2165-5979 Impact factor: 3.269

45 in total

1. Identification of genes that are associated with DNA repeats in prokaryotes.

Authors: Ruud Jansen; Jan D A van Embden; Wim Gaastra; Leo M Schouls
Journal: Mol Microbiol Date: 2002-03 Impact factor: 3.501

Review 2. Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering.

Authors: James K Nuñez; Lucas B Harrington; Jennifer A Doudna
Journal: ACS Chem Biol Date: 2016-02-09 Impact factor: 5.100

3. CRISPR germline engineering--the community speaks.

Authors: Katrine S Bosley; Michael Botchan; Annelien L Bredenoord; Dana Carroll; R Alta Charo; Emmanuelle Charpentier; Ron Cohen; Jacob Corn; Jennifer Doudna; Guoping Feng; Henry T Greely; Rosario Isasi; Weihzi Ji; Jin-Soo Kim; Bartha Knoppers; Edward Lanphier; Jinsong Li; Robin Lovell-Badge; G Steven Martin; Jonathan Moreno; Luigi Naldini; Martin Pera; Anthony C F Perry; J Craig Venter; Feng Zhang; Qi Zhou
Journal: Nat Biotechnol Date: 2015-05 Impact factor: 54.908

4. A face-lift for biotech rules begins.

Authors: Emily Waltz
Journal: Nat Biotechnol Date: 2015-12-09 Impact factor: 54.908

5. Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells.

Authors: Ayal Hendel; Rasmus O Bak; Joseph T Clark; Andrew B Kennedy; Daniel E Ryan; Subhadeep Roy; Israel Steinfeld; Benjamin D Lunstad; Robert J Kaiser; Alec B Wilkens; Rosa Bacchetta; Anya Tsalenko; Douglas Dellinger; Laurakay Bruhn; Matthew H Porteus
Journal: Nat Biotechnol Date: 2015-06-29 Impact factor: 54.908

6. Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems.

Authors: Sergey Shmakov; Omar O Abudayyeh; Kira S Makarova; Yuri I Wolf; Jonathan S Gootenberg; Ekaterina Semenova; Leonid Minakhin; Julia Joung; Silvana Konermann; Konstantin Severinov; Feng Zhang; Eugene V Koonin
Journal: Mol Cell Date: 2015-10-22 Impact factor: 17.970

Review 7. An updated evolutionary classification of CRISPR-Cas systems.

Authors: Kira S Makarova; Yuri I Wolf; Omer S Alkhnbashi; Fabrizio Costa; Shiraz A Shah; Sita J Saunders; Rodolphe Barrangou; Stan J J Brouns; Emmanuelle Charpentier; Daniel H Haft; Philippe Horvath; Sylvain Moineau; Francisco J M Mojica; Rebecca M Terns; Michael P Terns; Malcolm F White; Alexander F Yakunin; Roger A Garrett; John van der Oost; Rolf Backofen; Eugene V Koonin
Journal: Nat Rev Microbiol Date: 2015-09-28 Impact factor: 60.633

8. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes.

Authors: Puping Liang; Yanwen Xu; Xiya Zhang; Chenhui Ding; Rui Huang; Zhen Zhang; Jie Lv; Xiaowei Xie; Yuxi Chen; Yujing Li; Ying Sun; Yaofu Bai; Zhou Songyang; Wenbin Ma; Canquan Zhou; Junjiu Huang
Journal: Protein Cell Date: 2015-04-18 Impact factor: 14.870

9. CRISPR/Cas9 mediated genome editing in ES cells and its application for chimeric analysis in mice.

Authors: Asami Oji; Taichi Noda; Yoshitaka Fujihara; Haruhiko Miyata; Yeon Joo Kim; Masanaga Muto; Kaori Nozawa; Takafumi Matsumura; Ayako Isotani; Masahito Ikawa
Journal: Sci Rep Date: 2016-08-17 Impact factor: 4.379

Review 10. Patterns of CRISPR/Cas9 activity in plants, animals and microbes.

Authors: Luisa Bortesi; Changfu Zhu; Julia Zischewski; Lucia Perez; Ludovic Bassié; Riad Nadi; Giobbe Forni; Sarah Boyd Lade; Erika Soto; Xin Jin; Vicente Medina; Gemma Villorbina; Pilar Muñoz; Gemma Farré; Rainer Fischer; Richard M Twyman; Teresa Capell; Paul Christou; Stefan Schillberg
Journal: Plant Biotechnol J Date: 2016-10-11 Impact factor: 9.803

7 in total

CRISPR-Cas9: From a bacterial immune system to genome-edited human cells in clinical trials.

1. Identification of genes that are associated with DNA repeats in prokaryotes.

Review 2. Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering.

3. CRISPR germline engineering--the community speaks.

4. A face-lift for biotech rules begins.

5. Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells.

6. Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems.

Review 7. An updated evolutionary classification of CRISPR-Cas systems.

8. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes.

9. CRISPR/Cas9 mediated genome editing in ES cells and its application for chimeric analysis in mice.

Review 10. Patterns of CRISPR/Cas9 activity in plants, animals and microbes.

Review 1. Current and emerging therapies for corneal neovascularization.

Review 2. Challenges in delivery systems for CRISPR-based genome editing and opportunities of nanomedicine.

3. Use of RNA-Protein Complexes for Genome Editing in Non-albicans Candida Species.

Review 4. New and emerging uses of CRISPR/Cas9 to genetically manipulate apicomplexan parasites.

Review 5. A review of the therapeutic and biological effects of edible and wild mushrooms.

Review 6. Bioengineering tools for the production of pharmaceuticals: current perspective and future outlook.

Review 7. Impact of CRISPR-Cas9-Based Genome Engineering in Farm Animals.