Literature DB >> 26446298

Anti-tumor activity of lipophilic imidazolium salts on select NSCLC cell lines.

Brian D Wright1, Michael C Deblock1, Patrick O Wagers1, Ernest Duah1, Nikki K Robishaw1, Kerri L Shelton1, Marie R Southerland1, Michael A DeBord1, Kortney M Kersten1, Lucas J McDonald1, Jason A Stiel1, Matthew J Panzner1, Claire A Tessier1, Sailaja Paruchuri1, Wiley J Youngs1.   

Abstract

The anti-tumor activity of imidazolium salts is highly dependent upon the substituents on the nitrogen atoms of the imidazolium cation. We have synthesized and characterized a series of naphthalene-substituted imidazolium salts and tested them against a variety of non-smallcell lung cancer cell lines. Several of these complexes displayed anticancer activity comparable to cisplatin. These compounds induced apoptosis in the NCI-H460 cell line as determined by Annexin V staining, caspase-3, and PARP cleavage. These results strongly suggest that this class of compounds can serve as potent chemotherapeutic agents.

Entities:  

Keywords:  Anti-tumor; Anticancer; Apoptosis; Imidazolium cation; Imidazolium salt

Year:  2015        PMID： 26446298      PMCID： PMC4593509          DOI： 10.1007/s00044-015-1330-z

Source DB:  PubMed          Journal:  Med Chem Res        ISSN： 1054-2523            Impact factor:   1.965


  28 in total

1.  Synthesis, characterization, and antimicrobial activity of silver carbene complexes derived from 4,5,6,7-tetrachlorobenzimidazole against antibiotic resistant bacteria.

Authors:  Brian D Wright; Parth N Shah; Lucas J McDonald; Michael L Shaeffer; Patrick O Wagers; Matthew J Panzner; Justin Smolen; Jasur Tagaev; Claire A Tessier; Carolyn L Cannon; Wiley J Youngs
Journal:  Dalton Trans       Date:  2012-03-08       Impact factor: 4.390

2.  Nanoparticle encapsulated silver carbene complexes and their antimicrobial and anticancer properties: a perspective.

Authors:  Wiley J Youngs; Amanda R Knapp; Patrick O Wagers; Claire A Tessier
Journal:  Dalton Trans       Date:  2011-10-06       Impact factor: 4.390

3.  Synthesis, stability, and antimicrobial studies of electronically tuned silver acetate N-heterocyclic carbenes.

Authors:  Khadijah M Hindi; Tammy J Siciliano; Semih Durmus; Matthew J Panzner; Doug A Medvetz; D Venkat Reddy; Lisa A Hogue; Christine E Hovis; Julia K Hilliard; Rebekah J Mallet; Claire A Tessier; Carolyn L Cannon; Wiley J Youngs
Journal:  J Med Chem       Date:  2008-02-21       Impact factor: 7.446

4.  Coinage metal-N-heterocyclic carbene complexes.

Authors:  Joseph C Y Lin; Roy T W Huang; Chen S Lee; Amitabha Bhattacharyya; Wen S Hwang; Ivan J B Lin
Journal:  Chem Rev       Date:  2009-08       Impact factor: 60.622

Review 5.  Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure.

Authors:  M van Engeland; L J Nieland; F C Ramaekers; B Schutte; C P Reutelingsperger
Journal:  Cytometry       Date:  1998-01-01

Review 6.  Imidazolium salts and their polymeric materials for biological applications.

Authors:  Siti Nurhanna Riduan; Yugen Zhang
Journal:  Chem Soc Rev       Date:  2013-08-27       Impact factor: 54.564

7.  Cysteinyl leukotrienes regulate endothelial cell inflammatory and proliferative signals through CysLT₂ and CysLT₁ receptors.

Authors:  Ernest Duah; Ravi K Adapala; Nosayba Al-Azzam; Vinay Kondeti; Farai Gombedza; Charles K Thodeti; Sailaja Paruchuri
Journal:  Sci Rep       Date:  2013-11-20       Impact factor: 4.379

8.  Phase I and pharmacokinetic study of YM155, a small-molecule inhibitor of survivin.

Authors:  Anthony W Tolcher; Alain Mita; Lionel D Lewis; Christopher R Garrett; Elizabeth Till; Adil I Daud; Amita Patnaik; Kyri Papadopoulos; Chris Takimoto; Pamela Bartels; Anne Keating; Scott Antonia
Journal:  J Clin Oncol       Date:  2008-09-29       Impact factor: 50.717

9.  Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole.

Authors:  Doug A Medvetz; Khadijah M Hindi; Matthew J Panzner; Andrew J Ditto; Yang H Yun; Wiley J Youngs
Journal:  Met Based Drugs       Date:  2008

10.  Differential regulation of cysteinyl leukotriene receptor signaling by protein kinase C in human mast cells.

Authors:  Vinay Kondeti; Ernest Duah; Nosayba Al-Azzam; Charles K Thodeti; Joshua A Boyce; Sailaja Paruchuri
Journal:  PLoS One       Date:  2013-08-15       Impact factor: 3.240
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  9 in total

1.  Synthesis, anti-proliferative activity, SAR study, and preliminary in vivo toxicity study of substituted N,N'-bis(arylmethyl)benzimidazolium salts against a panel of non-small cell lung cancer cell lines.

Authors:  Kerri L Shelton; Michael A DeBord; Patrick O Wagers; Marie R Southerland; Travis M Williams; Nikki K Robishaw; Leah P Shriver; Claire A Tessier; Matthew J Panzner; Wiley J Youngs
Journal:  Bioorg Med Chem       Date:  2016-11-05       Impact factor: 3.641

2.  Imidazolium salts as small-molecule urinary bladder exfoliants in a murine model.

Authors:  Patrick O Wagers; Kristin M Tiemann; Kerri L Shelton; William G Kofron; Matthew J Panzner; Karen L Wooley; Wiley J Youngs; David A Hunstad
Journal:  Antimicrob Agents Chemother       Date:  2015-06-29       Impact factor: 5.191

3.  Synthesis, characterization, and in vitro SAR evaluation of N,N'-bis(arylmethyl)-C2-alkyl substituted imidazolium salts.

Authors:  Michael A DeBord; Patrick O Wagers; Steven R Crabtree; Claire A Tessier; Matthew J Panzner; Wiley J Youngs
Journal:  Bioorg Med Chem Lett       Date:  2016-11-24       Impact factor: 2.823

4.  Synthesis, characterization, in vitro SAR and in vivo evaluation of N,N'bisnaphthylmethyl 2-alkyl substituted imidazolium salts against NSCLC.

Authors:  Michael A DeBord; Marie R Southerland; Patrick O Wagers; Kristin M Tiemann; Nikki K Robishaw; Kyle T Whiddon; Michael C Konopka; Claire A Tessier; Leah P Shriver; Sailaja Paruchuri; David A Hunstad; Matthew J Panzner; Wiley J Youngs
Journal:  Bioorg Med Chem Lett       Date:  2017-01-16       Impact factor: 2.823

5.  Synthesis, characterization, in vitro SAR study, and preliminary in vivo toxicity evaluation of naphthylmethyl substituted bis-imidazolium salts.

Authors:  Marie R Southerland; Michael A DeBord; Nicholas A Johnson; Steven R Crabtree; Nicolas E Alexander; Michael L Stromyer; Patrick O Wagers; Matthew J Panzner; Chrys Wesdemiotis; Leah P Shriver; Claire A Tessier; Wiley J Youngs
Journal:  Bioorg Med Chem       Date:  2020-11-28       Impact factor: 3.641

Review 6.  Recent Developments in the Medicinal Applications of Silver-NHC Complexes and Imidazolium Salts.

Authors:  Nicholas A Johnson; Marie R Southerland; Wiley J Youngs
Journal:  Molecules       Date:  2017-07-27       Impact factor: 4.411

7.  In vitro evaluation of the antitumor effect of bismuth lipophilic nanoparticles (BisBAL NPs) on breast cancer cells.

Authors:  Rene Hernandez-Delgadillo; Claudia María García-Cuéllar; Yesennia Sánchez-Pérez; Nayely Pineda-Aguilar; Marco Antonio Martínez-Martínez; Eyra Elvyra Rangel-Padilla; Sergio Eduardo Nakagoshi-Cepeda; Juan Manuel Solís-Soto; Rosa Isela Sánchez-Nájera; María Argelia Akemi Nakagoshi-Cepeda; Shankararaman Chellam; Claudio Cabral-Romero
Journal:  Int J Nanomedicine       Date:  2018-10-05

8.  Synthesis, characterization, and biological activity of a triphenylphosphonium-containing imidazolium salt against select bladder cancer cell lines.

Authors:  Michael L Stromyer; Marie R Southerland; Uttam Satyal; Rahmat K Sikder; David J Weader; Jessi A Baughman; Wiley J Youngs; Philip H Abbosh
Journal:  Eur J Med Chem       Date:  2019-10-31       Impact factor: 7.088

9.  Bacillimidazoles A-F, Imidazolium-Containing Compounds Isolated from a Marine Bacillus.

Authors:  Jia-Xuan Yan; Qihao Wu; Eric J N Helfrich; Marc G Chevrette; Doug R Braun; Heino Heyman; Gene E Ananiev; Scott R Rajski; Cameron R Currie; Jon Clardy; Tim S Bugni
Journal:  Mar Drugs       Date:  2022-01-01       Impact factor: 5.118
  9 in total

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