Literature DB >> 18288795

Synthesis, stability, and antimicrobial studies of electronically tuned silver acetate N-heterocyclic carbenes.

Khadijah M Hindi1, Tammy J Siciliano, Semih Durmus, Matthew J Panzner, Doug A Medvetz, D Venkat Reddy, Lisa A Hogue, Christine E Hovis, Julia K Hilliard, Rebekah J Mallet, Claire A Tessier, Carolyn L Cannon, Wiley J Youngs.   

Abstract

A series of methylated imidazolium salts with varying substituents on the 4 and 5 positions of the imidazole ring were synthesized. These salts were reacted with silver acetate to afford their corresponding silver N-heterocyclic carbene (NHC) complexes. These complexes were then evaluated for their stability in water as well as for their antimicrobial efficacy against a variety of bacterial strains associated with cystic fibrosis and chronic lung infections.

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Year:  2008        PMID： 18288795     DOI： 10.1021/jm0708679

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  27 in total

1.  Synthesis, characterization, and antimicrobial activity of silver carbene complexes derived from 4,5,6,7-tetrachlorobenzimidazole against antibiotic resistant bacteria.

Authors:  Brian D Wright; Parth N Shah; Lucas J McDonald; Michael L Shaeffer; Patrick O Wagers; Matthew J Panzner; Justin Smolen; Jasur Tagaev; Claire A Tessier; Carolyn L Cannon; Wiley J Youngs
Journal:  Dalton Trans       Date:  2012-03-08       Impact factor: 4.390

2.  A theobromine derived silver N-heterocyclic carbene: synthesis, characterization, and antimicrobial efficacy studies on cystic fibrosis relevant pathogens.

Authors:  Matthew J Panzner; Khadijah M Hindi; Brian D Wright; Jane B Taylor; Daniel S Han; Wiley J Youngs; Carolyn L Cannon
Journal:  Dalton Trans       Date:  2009-08-06       Impact factor: 4.390

3.  Preparation and in vitro antimicrobial activity of silver-bearing degradable polymeric nanoparticles of polyphosphoester-block-poly(L-lactide).

Authors:  Young H Lim; Kristin M Tiemann; Gyu Seong Heo; Patrick O Wagers; Yohannes H Rezenom; Shiyi Zhang; Fuwu Zhang; Wiley J Youngs; David A Hunstad; Karen L Wooley
Journal:  ACS Nano       Date:  2015-01-26       Impact factor: 15.881

4.  Aerosolized antimicrobial agents based on degradable dextran nanoparticles loaded with silver carbene complexes.

Authors:  Cátia Ornelas-Megiatto; Parth N Shah; Peter R Wich; Jessica L Cohen; Jasur A Tagaev; Justin A Smolen; Brian D Wright; Matthew J Panzner; Wiley J Youngs; Jean M J Fréchet; Carolyn L Cannon
Journal:  Mol Pharm       Date:  2012-10-19       Impact factor: 4.939

5.  Shell crosslinked nanoparticles carrying silver antimicrobials as therapeutics.

Authors:  Yali Li; Khadijah Hindi; Kristin M Watts; Jane B Taylor; Ke Zhang; Zicheng Li; David A Hunstad; Carolyn L Cannon; Wiley J Youngs; Karen L Wooley
Journal:  Chem Commun (Camb)       Date:  2009-11-09       Impact factor: 6.222

6.  Luminescent di- and polynuclear organometallic gold(I)-metal (Au2, {Au2Ag}n and {Au2Cu}n) compounds containing bidentate phosphanes as active antimicrobial agents.

Authors:  Malgorzata Frik; Josefina Jiménez; Ismael Gracia; Larry R Falvello; Sarya Abi-Habib; Karina Suriel; Theodore R Muth; María Contel
Journal:  Chemistry       Date:  2012-02-14       Impact factor: 5.236

7.  Synthesis and antimicrobial studies of silver N-heterocyclic carbene complexes bearing a methyl benzoate substituent.

Authors:  Amanda R Knapp; Matthew J Panzner; Doug A Medvetz; Brian D Wright; Claire A Tessier; Wiley J Youngs
Journal:  Inorganica Chim Acta       Date:  2010-12-15       Impact factor: 2.545

8.  ATP7B detoxifies silver in ciliated airway epithelial cells.

Authors:  Aida Ibricevic; Steven L Brody; Wiley J Youngs; Carolyn L Cannon
Journal:  Toxicol Appl Pharmacol       Date:  2009-12-11       Impact factor: 4.219

9.  In vitro and murine efficacy and toxicity studies of nebulized SCC1, a methylated caffeine-silver(I) complex, for treatment of pulmonary infections.

Authors:  Carolyn L Cannon; Lisa A Hogue; Ravy K Vajravelu; George H Capps; Aida Ibricevic; Khadijah M Hindi; Aysegul Kascatan-Nebioglu; Michael J Walter; Steven L Brody; Wiley J Youngs
Journal:  Antimicrob Agents Chemother       Date:  2009-05-18       Impact factor: 5.191

10.  The antimicrobial efficacy of sustained release silver-carbene complex-loaded L-tyrosine polyphosphate nanoparticles: characterization, in vitro and in vivo studies.

Authors:  Khadijah M Hindi; Andrew J Ditto; Matthew J Panzner; Douglas A Medvetz; Daniel S Han; Christine E Hovis; Julia K Hilliard; Jane B Taylor; Yang H Yun; Carolyn L Cannon; Wiley J Youngs
Journal:  Biomaterials       Date:  2009-04-23       Impact factor: 12.479
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