Literature DB >> 26439710

Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids.

George P Liao1,2, Eman M M Abdelraheem1,3, Constantinos G Neochoritis1, Katarzyna Kurpiewska4, Justyna Kalinowska-Tłuścik4, David C McGowan2, Alexander Dömling1.   

Abstract

The direct macrocycle synthesis of α-isocyano-ω-carboxylic acids via an Ugi multicomponent reaction is introduced. This multicomponent reaction (MCR) protocol differs by being especially short, convergent, and versatile, giving access to 12-22 membered rings.

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Year:  2015        PMID： 26439710     DOI： 10.1021/acs.orglett.5b02419

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  13 in total

1.  Two-Step Synthesis of Complex Artificial Macrocyclic Compounds.

Authors:  Rudrakshula Madhavachary; Eman M M Abdelraheem; Arianna Rossetti; Aleksandra Twarda-Clapa; Bogdan Musielak; Katarzyna Kurpiewska; Justyna Kalinowska-Tłuścik; Tad A Holak; Alexander Dömling
Journal:  Angew Chem Int Ed Engl       Date:  2017-08-01       Impact factor: 15.336

Review 2.  The status of isocyanide-based multi-component reactions in Iran (2010-2018).

Authors:  Ronak Afshari; Seyyed Emad Hooshmand; Mohammad Taghi Nazeri; Siamak Javanbakht; Ahmad Shaabani; Reza Mohammadian
Journal:  Mol Divers       Date:  2020-02-18       Impact factor: 2.943

3.  Concise Synthesis of Macrocycles by Multicomponent Reactions.

Authors:  Eman M M Abdelraheem; Samad Khaksar; Alexander Dömling
Journal:  Synthesis (Stuttg)       Date:  2018-01-10       Impact factor: 3.157

Review 4.  Tetrazoles via Multicomponent Reactions.

Authors:  Constantinos G Neochoritis; Ting Zhao; Alexander Dömling
Journal:  Chem Rev       Date:  2019-02-01       Impact factor: 60.622

5.  Two-Step Macrocycle Synthesis by Classical Ugi Reaction.

Authors:  Eman M M Abdelraheem; Samad Khaksar; Katarzyna Kurpiewska; Justyna Kalinowska-Tłuścik; Shabnam Shaabani; Alexander Dömling
Journal:  J Org Chem       Date:  2018-01-24       Impact factor: 4.354

6.  Sulfur-Switch Ugi Reaction for Macrocyclic Disulfide-Bridged Peptidomimetics.

Authors:  Thimmalapura M Vishwanatha; Enrico Bergamaschi; Alexander Dömling
Journal:  Org Lett       Date:  2017-06-05       Impact factor: 6.005

7.  Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings.

Authors:  Eman M M Abdelraheem; Rudrakshula Madhavachary; Arianna Rossetti; Katarzyna Kurpiewska; Justyna Kalinowska-Tłuścik; Shabnam Shaabani; Alexander Dömling
Journal:  Org Lett       Date:  2017-10-30       Impact factor: 6.005

8.  Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists.

Authors:  Constantinos G Neochoritis; Maryam Kazemi Miraki; Eman M M Abdelraheem; Ewa Surmiak; Tryfon Zarganes-Tzitzikas; Beata Łabuzek; Tad A Holak; Alexander Dömling
Journal:  Beilstein J Org Chem       Date:  2019-02-20       Impact factor: 2.883

9.  Concise Synthesis of Tetrazole Macrocycle.

Authors:  Eman M M Abdelraheem; Michel P de Haan; Pravin Patil; Katarzyna Kurpiewska; Justyna Kalinowska-Tłuścik; Shabnam Shaabani; Alexander Dömling
Journal:  Org Lett       Date:  2017-09-13       Impact factor: 6.005

Review 10.  Library-to-Library Synthesis of Highly Substituted α-Aminomethyl Tetrazoles via Ugi Reaction.

Authors:  Pravin Patil; Bhupendra Mishra; Gitanjali Sheombarsing; Katarzyna Kurpiewska; Justyna Kalinowska-Tłuścik; Alexander Dömling
Journal:  ACS Comb Sci       Date:  2018-01-04       Impact factor: 3.784
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