| Literature DB >> 26437030 |
Helene Kretzmer1,2,3,4, Stephan H Bernhart1,2,3,4, Wei Wang5, Andrea Haake4,6, Marc A Weniger4,7, Anke K Bergmann6,8,9, Matthew J Betts10, Enrique Carrillo-de-Santa-Pau9,11, Gero Doose1,2,3,4, Jana Gutwein6, Julia Richter4,6, Volker Hovestadt5, Bingding Huang12, Daniel Rico9,11, Frank Jühling1,2,3, Julia Kolarova6, Qianhao Lu10, Christian Otto1,2,3, Rabea Wagener4,6, Judith Arnolds13, Birgit Burkhardt4,14, Alexander Claviez4,8, Hans G Drexler15, Sonja Eberth4,15,16, Roland Eils4,12,17, Paul Flicek9,18, Siegfried Haas4,19, Michael Humme4,20, Dennis Karsch4,21, Hinrik H D Kerstens9,22, Wolfram Klapper4,23, Markus Kreuz4,9,24, Chris Lawerenz4,12, Dido Lenzek4,20, Markus Loeffler4,9,24, Cristina López4,6, Roderick A F MacLeod15, Joost H A Martens9,22, Marta Kulis9,22, José Ignacio Martín-Subero9,25, Peter Möller4,26, Inga Nage4,6, Simone Picelli5, Inga Vater4,6, Marius Rohde4,27, Philip Rosenstiel4,28, Maciej Rosolowski4,24, Robert B Russell10, Markus Schilhabel4,28, Matthias Schlesner4,12, Peter F Stadler1,2,3,4,29,30,31, Monika Szczepanowski4, Lorenz Trümper4,16, Hendrik G Stunnenberg9,22, Ralf Küppers4,7,9, Ole Ammerpohl4,6, Peter Lichter4,5, Reiner Siebert4,6,9, Steve Hoffmann1,2,3,4,9, Bernhard Radlwimmer4,5.
Abstract
Although Burkitt lymphomas and follicular lymphomas both have features of germinal center B cells, they are biologically and clinically quite distinct. Here we performed whole-genome bisulfite, genome and transcriptome sequencing in 13 IG-MYC translocation-positive Burkitt lymphoma, nine BCL2 translocation-positive follicular lymphoma and four normal germinal center B cell samples. Comparison of Burkitt and follicular lymphoma samples showed differential methylation of intragenic regions that strongly correlated with expression of associated genes, for example, genes active in germinal center dark-zone and light-zone B cells. Integrative pathway analyses of regions differentially methylated in Burkitt and follicular lymphomas implicated DNA methylation as cooperating with somatic mutation of sphingosine phosphate signaling, as well as the TCF3-ID3 and SWI/SNF complexes, in a large fraction of Burkitt lymphomas. Taken together, our results demonstrate a tight connection between somatic mutation, DNA methylation and transcriptional control in key B cell pathways deregulated differentially in Burkitt lymphoma and other germinal center B cell lymphomas.Entities:
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Year: 2015 PMID： 26437030 PMCID： PMC5444523 DOI： 10.1038/ng.3413
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330