Literature DB >> 27019871

The Impact of DNA Methylation in Hematopoietic Malignancies.

Maria Guillamot1, Luisa Cimmino1, Iannis Aifantis1.   

Abstract

Aberrant DNA methylation is a characteristic feature of cancer including blood malignancies. Mutations in the DNA methylation regulators DNMT3A, TET1/2 and IDH1/2 are recurrent in leukemia and lymphoma. Specific and distinct DNA methylation patterns characterize subtypes of AML and lymphoma. Regulatory regions such as promoter CpG islands, CpG shores and enhancers show changes in methylation during transformation. However, the reported poor correlation between changes in methylation and gene expression in many mouse models and human studies reflects the complexity in the precise molecular mechanism for why aberrant DNA methylation promotes malignancies. This review will summarize current concepts regarding the mechanisms behind aberrant DNA methylation in hematopoietic malignancy and discuss its importance in cancer prognosis, tumor heterogeneity and relapse.

Entities:  

Keywords:  DNA methylation; epigenetics; leukemia; lymphoma

Year:  2016        PMID： 27019871      PMCID： PMC4806338          DOI： 10.1016/j.trecan.2015.12.006

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  137 in total

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Journal:  N Engl J Med       Date:  2015-05-07       Impact factor: 91.245

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Review 6.  TET family proteins and their role in stem cell differentiation and transformation.

Authors:  Luisa Cimmino; Omar Abdel-Wahab; Ross L Levine; Iannis Aifantis
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8.  Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis.

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10.  Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation.

Authors:  Lothar Schermelleh; Andrea Haemmer; Fabio Spada; Nicole Rösing; Daniela Meilinger; Ulrich Rothbauer; M Cristina Cardoso; Heinrich Leonhardt
Journal:  Nucleic Acids Res       Date:  2007-06-18       Impact factor: 16.971
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  28 in total

1.  Methylation maintains HSC division fate.

Authors:  Luisa Cimmino
Journal:  Proc Natl Acad Sci U S A       Date:  2017-01-03       Impact factor: 11.205

2.  Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.

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Journal:  Cell       Date:  2017-08-17       Impact factor: 41.582

3.  A single-cell epigenetic model for paternal psychological stress-induced transgenerational reprogramming in offspring.

Authors:  Jinzhi Lei; Qing Nie; Dong-Bao Chen
Journal:  Biol Reprod       Date:  2018-06-01       Impact factor: 4.285

Review 4.  Germline Abnormalities in DNA Methylation and Histone Modification and Associated Cancer Risk.

Authors:  Jenna A Fernandez; Mrinal M Patnaik
Journal:  Curr Hematol Malig Rep       Date:  2022-06-02       Impact factor: 4.213

5.  TET family dioxygenases and the TET activator vitamin C in immune responses and cancer.

Authors:  Xiaojing Yue; Anjana Rao
Journal:  Blood       Date:  2020-09-17       Impact factor: 22.113

Review 6.  Vitamin C in Stem Cell Reprogramming and Cancer.

Authors:  Luisa Cimmino; Benjamin G Neel; Iannis Aifantis
Journal:  Trends Cell Biol       Date:  2018-04-30       Impact factor: 20.808

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Authors:  Takahiro Maeda
Journal:  Int J Hematol       Date:  2016-06-01       Impact factor: 2.490

Review 8.  A feedback loop: Interactions between Inflammatory Signals and Clonal Hematopoiesis in Cardiovascular Disease.

Authors:  Jiashan Li; Chao Wang; Jiaru Liu; Ying Yu; Yuee Liu; Qi Peng; Huihui Liu; Xiuru Guan
Journal:  Mol Biol Rep       Date:  2021-05-13       Impact factor: 2.316

Review 9.  DNA methylation: a saga of genome maintenance in hematological perspective.

Authors:  Saran Chattopadhyaya; Somnath Ghosal
Journal:  Hum Cell       Date:  2022-01-22       Impact factor: 4.174

10.  STAT5BN642H is a driver mutation for T cell neoplasia.

Authors:  Ha Thi Thanh Pham; Barbara Maurer; Michaela Prchal-Murphy; Reinhard Grausenburger; Eva Grundschober; Tahereh Javaheri; Harini Nivarthi; Auke Boersma; Thomas Kolbe; Mohamed Elabd; Florian Halbritter; Jan Pencik; Zahra Kazemi; Florian Grebien; Markus Hengstschläger; Lukas Kenner; Stefan Kubicek; Matthias Farlik; Christoph Bock; Peter Valent; Mathias Müller; Thomas Rülicke; Veronika Sexl; Richard Moriggl
Journal:  J Clin Invest       Date:  2017-12-04       Impact factor: 14.808
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