Literature DB >> 2643462

Magnetic resonance spectroscopy of tumors and potential in vivo clinical applications: a review.

P F Daly1, J S Cohen.   

Abstract

The development of nuclear magnetic resonance (NMR) spectroscopy as an established research tool for noninvasive studies of cancer cells and for in vivo studies of tumors in animals and humans has led to the possibility that this technique may be used in the future for clinical research studies and monitoring of therapy in cancer patients in combination with magnetic resonance imaging. This article provides a brief qualitative explanation of NMR spectroscopy and then reviews the cell and animal studies detailing which biochemicals can be observed in vivo by 31P, 13C, and 1H NMR. The human studies done to date and their potential for diagnosis and monitoring of therapy are then discussed. In addition, 19F NMR spectroscopic studies of fluorinated drugs and 1H and 31P NMR studies relating to drug resistance are mentioned. The current technical limitations and developing improvements are indicated also.

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Year:  1989        PMID： 2643462

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  30 in total

Review 1.  Three-dimensional magnetic resonance spectroscopic imaging of brain and prostate cancer.

Authors:  J Kurhanewicz; D B Vigneron; S J Nelson
Journal:  Neoplasia       Date:  2000 Jan-Apr       Impact factor: 5.715

Review 2.  Cancer nanomedicines targeting tumor extracellular pH.

Authors:  Li Tian; You Han Bae
Journal:  Colloids Surf B Biointerfaces       Date:  2011-10-25       Impact factor: 5.268

Review 3.  NMR studies of drug metabolism and disposition.

Authors:  J D Bell; D G Gadian; N E Preece
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1990 Apr-Jun       Impact factor: 2.441

4.  Complete separation of intracellular and extracellular information in NMR spectra of perfused cells by diffusion-weighted spectroscopy.

Authors:  P C Van Zijl; C T Moonen; P Faustino; J Pekar; O Kaplan; J S Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

5.  Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders.

Authors:  Krissy A R Doyle-Thomas; Dallas Card; Latha V Soorya; A Ting Wang; Jin Fan; Evdokia Anagnostou
Journal:  Res Autism Spectr Disord       Date:  2014-01

6.  Non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis model: Omega-3 fatty acids prevent liver neoplasia.

Authors:  J Griffitts; D Saunders; Y A Tesiram; G E Reid; A Salih; S Liu; T A Lydic; J V Busik; J X Kang; R A Towner
Journal:  Biochim Biophys Acta       Date:  2010-07-08

Review 7.  [Importance of cell self-organization for tumor biology].

Authors:  B Wolf; M Kraus
Journal:  Naturwissenschaften       Date:  1993-08

8.  Preoperative proton MR spectroscopic imaging of brain tumors: correlation with histopathologic analysis of resection specimens.

Authors:  C Dowling; A W Bollen; S M Noworolski; M W McDermott; N M Barbaro; M R Day; R G Henry; S M Chang; W P Dillon; S J Nelson; D B Vigneron
Journal:  AJNR Am J Neuroradiol       Date:  2001-04       Impact factor: 3.825

9.  Metabonomic studies of pancreatic cancer response to radiotherapy in a mouse xenograft model using magnetic resonance spectroscopy and principal components analysis.

Authors:  Xin-Hong He; Wen-Tao Li; Ya-Jia Gu; Bao-Feng Yang; Hui-Wen Deng; Yi-Hua Yu; Wei-Jun Peng
Journal:  World J Gastroenterol       Date:  2013-07-14       Impact factor: 5.742

10.  Meningioma phospholipid profiles measured by 31P nuclear magnetic resonance spectroscopy.

Authors:  L Seijo; T E Merchant; L T van der Ven; B D Minsky; T Glonek
Journal:  Lipids       Date:  1994-05       Impact factor: 1.880
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