Literature DB >> 2643107

Copper-induced binding of cellular factors to yeast metallothionein upstream activation sequences.

J M Huibregtse1, D R Engelke, D J Thiele.   

Abstract

Copper-inducible transcription of the yeast metallothionein gene (CUP1) occurs by means of cis-acting upstream activation sequences (UAS) and trans-acting cellular factors. We have used a high-resolution chromosomal footprinting technique to detect the interaction of cellular factors with UASCUP1. Our results demonstrate that one or more cellular factors bind to UASCUP1 in a copper-inducible fashion. This copper-inducible binding is enhanced in a yeast strain that harbors several copies of the positive regulatory gene ACE1 and is not detectable in yeast cells that contain a nonfunctional (ace1-delta 1) locus. The correlation between yeast metallothionein gene activation and copper-inducible occupation of UASCUP1 sequences suggests that the binding of metallothionein transcriptional regulatory factors to cis-acting control sequences is copper-inducible.

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Year:  1989        PMID： 2643107      PMCID： PMC286404          DOI： 10.1073/pnas.86.1.65

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

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Authors:  A BRENES-POMALES; G LINDEGREN; C C LINDEGREN
Journal:  Nature       Date:  1955-10-29       Impact factor: 49.962

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Authors:  M Karin
Journal:  Cell       Date:  1985-05       Impact factor: 41.582

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Authors:  D J Thiele; M J Walling; D H Hamer
Journal:  Science       Date:  1986-02-21       Impact factor: 47.728

Review 4.  Chemistry and biochemistry of metallothionein.

Authors:  J H Kägi; Y Kojima
Journal:  Experientia Suppl       Date:  1987

5.  Comparison of tRNA gene transcription complexes formed in vitro and in nuclei.

Authors:  J M Huibregtse; C F Evans; D R Engelke
Journal:  Mol Cell Biol       Date:  1987-09       Impact factor: 4.272

6.  Promoters, activator proteins, and the mechanism of transcriptional initiation in yeast.

Authors:  K Struhl
Journal:  Cell       Date:  1987-05-08       Impact factor: 41.582

7.  Constitutive and metal-inducible protein:DNA interactions at the mouse metallothionein I promoter examined by in vivo and in vitro footprinting.

Authors:  P R Mueller; S J Salser; B Wold
Journal:  Genes Dev       Date:  1988-04       Impact factor: 11.361

8.  Metal-dependent binding of a factor in vivo to the metal-responsive elements of the metallothionein 1 gene promoter.

Authors:  R D Andersen; S J Taplitz; S Wong; G Bristol; B Larkin; H R Herschman
Journal:  Mol Cell Biol       Date:  1987-10       Impact factor: 4.272

9.  Saccharomyces cerevisiae killer virus transcripts contain template-coded polyadenylate tracts.

Authors:  E M Hannig; D J Thiele; M J Leibowitz
Journal:  Mol Cell Biol       Date:  1984-01       Impact factor: 4.272

10.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205
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  34 in total

1.  The CUP1 upstream repeated element renders CUP1 promoter activation insensitive to mutations in the RNA polymerase II transcription complex.

Authors:  Laura Badi; Alcide Barberis
Journal:  Nucleic Acids Res       Date:  2002-03-15       Impact factor: 16.971

Review 2.  Metal-responsive transcription factors that regulate iron, zinc, and copper homeostasis in eukaryotic cells.

Authors:  Julian C Rutherford; Amanda J Bird
Journal:  Eukaryot Cell       Date:  2004-02

3.  Cooperative activation of a eukaryotic transcription factor: interaction between Cu(I) and yeast ACE1 protein.

Authors:  P Fürst; D Hamer
Journal:  Proc Natl Acad Sci U S A       Date:  1989-07       Impact factor: 11.205

4.  Copper and the ACE1 regulatory protein reversibly induce yeast metallothionein gene transcription in a mouse extract.

Authors:  V C Culotta; T Hsu; S Hu; P Fürst; D Hamer
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

5.  Mechanisms of contact-mediated killing of yeast cells on dry metallic copper surfaces.

Authors:  Davide Quaranta; Travis Krans; Christophe Espírito Santo; Christian G Elowsky; Dylan W Domaille; Christopher J Chang; Gregor Grass
Journal:  Appl Environ Microbiol       Date:  2010-11-19       Impact factor: 4.792

6.  Identification of negative cis-acting elements in response to copper in the chloroplastic iron superoxide dismutase gene of the moss Barbula unguiculata.

Authors:  Miwa Nagae; Masaru Nakata; Yohsuke Takahashi
Journal:  Plant Physiol       Date:  2008-02-07       Impact factor: 8.340

7.  A nuclear factor binds to the metal regulatory elements of the mouse gene encoding metallothionein-I.

Authors:  S Labbé; J Prévost; P Remondelli; A Leone; C Séguin
Journal:  Nucleic Acids Res       Date:  1991-08-11       Impact factor: 16.971

8.  Genome-wide measurement of protein-DNA binding dynamics using competition ChIP.

Authors:  Colin R Lickwar; Florian Mueller; Jason D Lieb
Journal:  Nat Protoc       Date:  2013-06-13       Impact factor: 13.491

9.  Dynamic regulation of copper uptake and detoxification genes in Saccharomyces cerevisiae.

Authors:  M M Peña; K A Koch; D J Thiele
Journal:  Mol Cell Biol       Date:  1998-05       Impact factor: 4.272

10.  The gene for cadmium metallothionein from a cadmium-resistant yeast appears to be identical to CUP1 in a copper-resistant strain.

Authors:  H Tohoyama; T Tomoyasu; M Inouhe; M Joho; T Murayama
Journal:  Curr Genet       Date:  1992-04       Impact factor: 3.886
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