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Literature DB >> 3080806

Mammalian metallothionein is functional in yeast.

Abstract

Expression of two monkey metallothioneins in yeast leads to complementation of both known functions of the endogenous yeast copperthionein gene, namely copper detoxification and autoregulation of transcription. The metallothionein-like proteins of higher and lower eukaryotes are therefore functionally analogous despite their dissimilar primary sequences.

Entities: Chemical Species

Mesh：

Substances：
Copper
Metallothionein

Year: 1986 PMID： 3080806 DOI： 10.1126/science.3080806

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

21 in total

1. Differential expression of a metallothionein gene during the presymbiotic versus the symbiotic phase of an arbuscular mycorrhizal fungus.

Authors: Luisa Lanfranco; Angelo Bolchi; Emanuele Cesale Ros; Simone Ottonello; Paola Bonfante
Journal: Plant Physiol Date: 2002-09 Impact factor: 8.340

2. Isolation of a metal-activated transcription factor gene from Candida glabrata by complementation in Saccharomyces cerevisiae.

Authors: P B Zhou; D J Thiele
Journal: Proc Natl Acad Sci U S A Date: 1991-07-15 Impact factor: 11.205

3. The copper regulon of the human fungal pathogen Cryptococcus neoformans H99.

Authors: Chen Ding; Jun Yin; Edgar Mauricio Medina Tovar; David A Fitzpatrick; Desmond G Higgins; Dennis J Thiele
Journal: Mol Microbiol Date: 2011-08-23 Impact factor: 3.501

4. Expression of mouse metallothionein in the cyanobacterium Synechococcus PCC7942.

Authors: J L Erbe; K B Taylor; L M Hall
Journal: J Ind Microbiol Date: 1996-07

5. Chromogenic identification of oligonucleotide-directed mutants.

Authors: C F Wright; D H Hamer; K McKenney
Journal: Nucleic Acids Res Date: 1986-11-11 Impact factor: 16.971

6. Isolation and characterization of genes expressed uniquely during appressorium formation by Colletotrichum gloeosporioides conidia induced by the host surface wax.

Authors: C S Hwang; P E Kolattukudy
Journal: Mol Gen Genet Date: 1995-05-10

Mammalian metallothionein is functional in yeast.

1. Differential expression of a metallothionein gene during the presymbiotic versus the symbiotic phase of an arbuscular mycorrhizal fungus.

2. Isolation of a metal-activated transcription factor gene from Candida glabrata by complementation in Saccharomyces cerevisiae.

3. The copper regulon of the human fungal pathogen Cryptococcus neoformans H99.

4. Expression of mouse metallothionein in the cyanobacterium Synechococcus PCC7942.

5. Chromogenic identification of oligonucleotide-directed mutants.

6. Isolation and characterization of genes expressed uniquely during appressorium formation by Colletotrichum gloeosporioides conidia induced by the host surface wax.

Review 7. Involvement of metallothionein and copper in cell proliferation.

8. Functional homologs of fungal metallothionein genes from Arabidopsis.

9. Identification and analysis of a Saccharomyces cerevisiae copper homeostasis gene encoding a homeodomain protein.

10. Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase.