Clinical Significance of Esophageal Hypertensive Peristaltic Contractions on High-resolution Manometry(Neurogastroenterol Motil 2015;27:229-236).

Summary

Esophageal peristalsis consists of a chain of relaxing sphincters and contracting segments. First, the segment of skeletal muscle (S1) contracts, then the proximal segment of smooth muscle (S2), and finally the distal segment of smooth muscle (S3).1 The esophageal hypercontractility disorder has been postulated to be caused by imbalance between esophageal contraction and relaxation. A variant of this disorder, where contraction amplitudes of S3 are disproportionately exaggerated compared with those of S2, can produce esophageal symptoms.2 However, some of these contraction patterns could be averaged out and may not be registered as abnormal. Therefore, Mello et al3 tried to determine the clinical significance of these contraction patterns and the diagnostic sensitivity of Chicago classification for these patterns.

The authors found that merged segments were in 5.6%, and exaggerated S3 in another 12.5%, but only 17–50% had a Chicago classification diagnosis. The cohorts with merged segments and exaggerated S3 had significantly higher proportions of abnormal relaxation of esophageal body during multiple rapid swallowing (MRS) (P < 0.005 for each comparison) and presenting symptoms (chest pain and dysphagia, P = 0.040) than healthy controls. The authors concluded that merged segments and exaggerated S3 may represent esophageal hypercontractility disorder from abnormal relaxation and/or contraction, and the Chicago classification for these contraction patterns may not be sensitive.

Comments

The clinical relevance of esophageal hypercontractility disorders is still debated because the symptoms are not correlated with the amplitude of esophageal peristalsis.4 It is also controversial whether nutcracker esophagus is a true esophageal motor disorder or only a manometric marker in non-cardiac chest pain.5

This study showed that merged segments and exaggerated S3 in high-resolution manometry (HRM) could be encountered in symptomatic patients, but also be seen even in healthy controls at low rate. However, these contraction patterns in HRM can show up in very heterogeneous group of patients. Depending on the results of distal contractile integral response (DCI) to multiple rapid swallowing, DCIs of some merged segments and exaggerated S3 were over 5000 mmHg · cm · sec. Furthermore, about 18% (6/34) of exaggerated S3 was over 8000 mmHg · cm · sec. It means that quite a number of patients with merged segments and exaggerated S3 in HRM could be diagnosed as “nutcracker esophagus” and “Jackhammer esophagus,” and these patients could be more likely to have symptoms such as heartburn, chest pain, and dysphagia,6,7 than those with low DCI and merged segments and exaggerated S3. As a result, these contraction patterns in HRM, low DCI and merged esophageal smooth muscle segments and exaggerated S3 do not seem to represent as clinically significant HRM findings.

Recently, the significance of hypertensive peristaltic contractions (DCI 5000–8000 mmHg · cm · sec) was questioned and the designation of “hypertensive peristalsis” was eliminated in Chicago classification version 3.0.8 Also, jackhammer esophagus was redefined as the occurrence of 20% of swallows, instead of “at least one swallow,” with a DCI > 8000 mmHg · cm · sec and normal latency. The investigation into the better criteria for esophageal hypertensive peristaltic contractions is still in progress.