Izzuddin M Aris1, Shu E Soh2, Mya Thway Tint3, Seang Mei Saw4, Victor S Rajadurai5, Keith M Godfrey6, Peter D Gluckman7, Fabian Yap8, Yap Seng Chong9, Yung Seng Lee10. 1. Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore; Departments of Paediatrics and. 2. Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore; Departments of. 3. Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, and. 4. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore; Departments of. 5. Neonatology and. 6. Medical Research Council Lifecourse Epidemiology Unit and National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom; 7. Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore; Departments of Liggins Institute, University of Auckland, Auckland, New Zealand; 8. Paediatrics, KK Women's and Children's Hospital, Singapore; Duke-National University of Singapore Graduate Medical School, Lee Kong Chian School of Medicine, Singapore; and. 9. Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore; Departments of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, and. 10. Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore; Departments of Paediatrics and Division of Paediatric Endocrinology and Diabetes, Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, National University Health System, Singapore paeleeys@nus.edu.sg.
Abstract
BACKGROUND: Maternal obesity and hyperglycemia increase risk of obesity and diabetes in offspring later in life. OBJECTIVE: We examined the relation between gestational glycemia and prepregnancy body mass index (ppBMI) with offspring growth in an Asian mother-offspring cohort. DESIGN: Pregnant mothers undertook a 75-g 2-h oral-glucose-tolerance test at 26-28 wk of gestation. In 937 singleton offspring, ≤9 serial measurements of weight and length were obtained from birth until 36 mo of age. RESULTS: Gestational fasting plasma glucose (FPG) was positively associated with birth weight (B: 0.17; 95% CI: 0.10, 0.24; P < 0.001) and birth BMI (B: 0.15; 95% CI: 0.06, 0.40; P = 0.001) but not at ≥3 mo of age. In contrast, maternal ppBMI was positively associated with birth variables and conditional growth in weight and BMI in the first 36 mo of life. However, gestational FPG and prepregnancy obesity status interacted significantly for the association with offspring growth and overweight status in the first 36 mo of life (P-interaction < 0.01). In nonobese mothers, each unit increase in gestational FPG was associated with increased offspring weight (B: 0.08; 95% CI: 0.008, 0.16; P = 0.03) and BMI (B: 0.08; 95% CI: 0.003, 0.15; P = 0.04) as well as increased risk of overweight in the first 36 mo of life (OR: 1.36; 95% CI: 1.10, 1.68). However, in obese mothers, each unit increase in gestational FPG was associated with decreased offspring weight (B: -0.01; 95% CI: -0.02, -0.003) and BMI (B: -0.008; 95% CI: -0.01, -0.002) velocity (P < 0.01 for both) and decreased risk of overweight (OR: 0.59; 95% CI: 0.41, 0.86) in the first 36 mo of life. CONCLUSIONS: Prepregnancy adiposity was associated with offspring growth in early childhood. Although pooled analyses showed no demonstrable difference by 3 mo of age, there were contrasting and opposite associations of gestational glycemia with weight and BMI in the first 36 mo of life in offspring of nonobese and obese mothers separately. This study was registered at clinicaltrials.gov as NCT01174875.
BACKGROUND: Maternal obesity and hyperglycemia increase risk of obesity and diabetes in offspring later in life. OBJECTIVE: We examined the relation between gestational glycemia and prepregnancy body mass index (ppBMI) with offspring growth in an Asian mother-offspring cohort. DESIGN: Pregnant mothers undertook a 75-g 2-h oral-glucose-tolerance test at 26-28 wk of gestation. In 937 singleton offspring, ≤9 serial measurements of weight and length were obtained from birth until 36 mo of age. RESULTS: Gestational fasting plasma glucose (FPG) was positively associated with birth weight (B: 0.17; 95% CI: 0.10, 0.24; P < 0.001) and birth BMI (B: 0.15; 95% CI: 0.06, 0.40; P = 0.001) but not at ≥3 mo of age. In contrast, maternal ppBMI was positively associated with birth variables and conditional growth in weight and BMI in the first 36 mo of life. However, gestational FPG and prepregnancy obesity status interacted significantly for the association with offspring growth and overweight status in the first 36 mo of life (P-interaction < 0.01). In nonobese mothers, each unit increase in gestational FPG was associated with increased offspring weight (B: 0.08; 95% CI: 0.008, 0.16; P = 0.03) and BMI (B: 0.08; 95% CI: 0.003, 0.15; P = 0.04) as well as increased risk of overweight in the first 36 mo of life (OR: 1.36; 95% CI: 1.10, 1.68). However, in obese mothers, each unit increase in gestational FPG was associated with decreased offspring weight (B: -0.01; 95% CI: -0.02, -0.003) and BMI (B: -0.008; 95% CI: -0.01, -0.002) velocity (P < 0.01 for both) and decreased risk of overweight (OR: 0.59; 95% CI: 0.41, 0.86) in the first 36 mo of life. CONCLUSIONS: Prepregnancy adiposity was associated with offspring growth in early childhood. Although pooled analyses showed no demonstrable difference by 3 mo of age, there were contrasting and opposite associations of gestational glycemia with weight and BMI in the first 36 mo of life in offspring of nonobese and obese mothers separately. This study was registered at clinicaltrials.gov as NCT01174875.
Authors: I M Aris; J Y Bernard; L-W Chen; M T Tint; W W Pang; S E Soh; S-M Saw; L P-C Shek; K M Godfrey; P D Gluckman; Y-S Chong; F Yap; M S Kramer; Y S Lee Journal: Int J Obes (Lond) Date: 2017-07-28 Impact factor: 5.095
Authors: Izzuddin M Aris; Jonathan Y Bernard; Ling-Wei Chen; Mya Thway Tint; Wei Wei Pang; Wai Yee Lim; Shu E Soh; Seang-Mei Saw; Keith M Godfrey; Peter D Gluckman; Yap-Seng Chong; Fabian Yap; Michael S Kramer; Yung Seng Lee Journal: Int J Epidemiol Date: 2017-04-01 Impact factor: 7.196
Authors: Jonathan Y Bernard; Mya-Thway Tint; Izzuddin M Aris; Ling-Wei Chen; Phaik Ling Quah; Kok Hian Tan; George Seow-Heong Yeo; Marielle V Fortier; Fabian Yap; Lynette Shek; Yap-Seng Chong; Peter D Gluckman; Keith M Godfrey; Philip C Calder; Mary F F Chong; Michael S Kramer; Jérémie Botton; Yung Seng Lee Journal: Prostaglandins Leukot Essent Fatty Acids Date: 2017-06-09 Impact factor: 4.006
Authors: Linde van Lee; Sarah R Crozier; Izzuddin M Aris; Mya T Tint; Suresh Anand Sadananthan; Navin Michael; Phaik Ling Quah; Sian M Robinson; Hazel M Inskip; Nicholas C Harvey; Mary Barker; Cyrus Cooper; Sendhil S Velan; Yung Seng Lee; Marielle V Fortier; Fabian Yap; Peter D Gluckman; Kok Hian Tan; Lynette P Shek; Yap-Seng Chong; Keith M Godfrey; Mary F F Chong Journal: Int J Epidemiol Date: 2019-04-01 Impact factor: 7.196
Authors: Yi Ying Ong; Suresh Anand Sadananthan; Izzuddin M Aris; Mya Thway Tint; Wen Lun Yuan; Jonathan Y Huang; Yiong Huak Chan; Sharon Ng; See Ling Loy; Sendhil S Velan; Marielle V Fortier; Keith M Godfrey; Lynette Shek; Kok Hian Tan; Peter D Gluckman; Fabian Yap; Jonathan Tze Liang Choo; Lieng Hsi Ling; Karen Tan; Li Chen; Neerja Karnani; Yap-Seng Chong; Johan G Eriksson; Mary E Wlodek; Shiao-Yng Chan; Yung Seng Lee; Navin Michael Journal: Int J Epidemiol Date: 2020-10-01 Impact factor: 7.196
Authors: Bernadeta Patro Golab; Susana Santos; Ellis Voerman; Debbie A Lawlor; Vincent W V Jaddoe; Romy Gaillard Journal: Lancet Child Adolesc Health Date: 2018-09-07