Literature DB >> 26419594

BMP10 inhibited the growth and migration of gastric cancer cells.

Haiming Lei1, Jian Wang2, Peihua Lu3, Xinghua Si1, Koulan Han1, Tingyan Ruan3, Junjie Lu4.   

Abstract

Bone morphogenetic protein 10 (BMP10), a novel member of BMP family, has been identified as an important regulator for angiogenesis. Dysregulation of BMP has been observed in several cancer types. However, its roles in gastric cancer (GC) remain unknown. In this study, the expression of BMP10 was found to be down-regulated in GC samples. Forced expression of BMP10 in GC cells inhibited its growth and migration, while knocking down the expression of BMP10 in GC cells promoted cell growth, migration, and metastasis. BMP10 was shown to negatively regulated beta-catenin/TCF signaling by up-regulating Axin protein level. Taken together, the present study revealed the suppressive function of BMP10 in gastric cancer.

Entities:  

Keywords:  Axin; BMP10; Beta-catenin/TCF signaling; Cell growth and migration

Mesh：

Substances：

Year:  2015        PMID： 26419594     DOI： 10.1007/s13277-015-4116-5

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  25 in total

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5.  Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells.

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6.  Interaction between the transforming growth factor-beta type II receptor/Smad pathway and beta-catenin during transforming growth factor-beta1-mediated adherens junction disassembly.

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Journal:  Am J Pathol       Date:  2002-05       Impact factor: 4.307

7.  Overexpression of bone morphogenic protein (BMP)-4 mRNA in gastric cancer cell lines of poorly differentiated type.

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9.  The Bone Morphogenesis Protein-2 (BMP-2) is associated with progression to metastatic disease in gastric cancer.

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10.  Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation.

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  5 in total

1.  Hypermethylation of the CHRDL1 promoter induces proliferation and metastasis by activating Akt and Erk in gastric cancer.

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2.  FSTL3 is a Prognostic Biomarker in Gastric Cancer and is Correlated with M2 Macrophage Infiltration.

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Review 3.  BMP signaling and its paradoxical effects in tumorigenesis and dissemination.

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4.  A novel scoring system for gastric cancer risk assessment based on the expression of three CLIP4 DNA methylation-associated genes.

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Review 5.  The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer.

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Journal:  Cells       Date:  2019-09-23       Impact factor: 6.600
  5 in total

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