Literature DB >> 23032367

Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch.

Fred E Bertrand1, C William Angus, William J Partis, George Sigounas.   

Abstract

A hallmark of cancer is reactivation/alteration of pathways that control cellular differentiation during developmental processes. Evidence indicates that WNT, Notch, BMP and Hedgehog pathways have a role in normal epithelial cell differentiation, and that alterations in these pathways accompany establishment of the tumorigenic state. Interestingly, there is recent evidence that these pathways are intertwined at the molecular level, and these nodes of intersection may provide opportunities for effective targeted therapies. This review will highlight the role of the WNT, Notch, BMP and Hedgehog pathways in colon cancer.

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Year:  2012        PMID： 23032367      PMCID： PMC3552917          DOI： 10.4161/cc.22134

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  124 in total

1.  Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.

Authors:  J Roose; G Huls; M van Beest; P Moerer; K van der Horn; R Goldschmeding; T Logtenberg; H Clevers
Journal:  Science       Date:  1999-09-17       Impact factor: 47.728

Review 2.  The Hedgehog and Wnt signalling pathways in cancer.

Authors:  J Taipale; P A Beachy
Journal:  Nature       Date:  2001-05-17       Impact factor: 49.962

3.  The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling.

Authors:  S Dihlmann; A Siermann; M von Knebel Doeberitz
Journal:  Oncogene       Date:  2001-02-01       Impact factor: 9.867

Review 4.  Colorectal cancer.

Authors:  David Cunningham; Wendy Atkin; Heinz-Josef Lenz; Henry T Lynch; Bruce Minsky; Bernard Nordlinger; Naureen Starling
Journal:  Lancet       Date:  2010-03-20       Impact factor: 79.321

Review 5.  Metastatic basal cell carcinoma in the era of hedgehog signaling pathway inhibitors.

Authors:  Glen J Weiss; Ronald L Korn
Journal:  Cancer       Date:  2012-04-17       Impact factor: 6.860

6.  Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice.

Authors:  Teruaki Fujishita; Koji Aoki; Heidi A Lane; Masahiro Aoki; Makoto M Taketo
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-03       Impact factor: 11.205

7.  Linear model of colon cancer initiation.

Authors:  Franziska Michor; Yoh Iwasa; Harith Rajagopalan; Christoph Lengauer; Martin A Nowak
Journal:  Cell Cycle       Date:  2004-03-01       Impact factor: 4.534

8.  TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.

Authors:  L W Ellisen; J Bird; D C West; A L Soreng; T C Reynolds; S D Smith; J Sklar
Journal:  Cell       Date:  1991-08-23       Impact factor: 41.582

9.  A phase II study of RO4929097 in metastatic colorectal cancer.

Authors:  Jonathan R Strosberg; Timothy Yeatman; Jill Weber; Domenico Coppola; Michael J Schell; Gang Han; Khaldoun Almhanna; Richard Kim; Tiffany Valone; Helen Jump; Dan Sullivan
Journal:  Eur J Cancer       Date:  2012-03-23       Impact factor: 9.162

10.  The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and non-canonical Wnt signaling.

Authors:  Shaheen Sikandar; Diana Dizon; Xiling Shen; Zuomei Li; Jeffery Besterman; Steven M Lipkin
Journal:  Oncotarget       Date:  2010-11
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  71 in total

1.  Scutellaria barbata D. Don inhibits colorectal cancer growth via suppression of Wnt/β-catenin signaling pathway.

Authors:  Li-Hui Wei; Jiu-Mao Lin; Jian-Feng Chu; Hong-Wei Chen; Qing-Yu Li; Jun Peng
Journal:  Chin J Integr Med       Date:  2017-10-28       Impact factor: 1.978

2.  SMO expression in colorectal cancer: associations with clinical, pathological, and molecular features.

Authors:  Tingting Li; Xiaoyun Liao; Paul Lochhead; Teppei Morikawa; Mai Yamauchi; Reiko Nishihara; Kentaro Inamura; Sun A Kim; Kosuke Mima; Yasutaka Sukawa; Aya Kuchiba; Yu Imamura; Yoshifumi Baba; Kaori Shima; Jeffrey A Meyerhardt; Andrew T Chan; Charles S Fuchs; Shuji Ogino; Zhi Rong Qian
Journal:  Ann Surg Oncol       Date:  2014-07-15       Impact factor: 5.344

3.  Chronic chemotherapeutic stress promotes evolution of stemness and WNT/beta-catenin signaling in colorectal cancer cells: implications for clinical use of WNT-signaling inhibitors.

Authors:  Meriam Ayadi; Anaïs Bouygues; Djamila Ouaret; Nathalie Ferrand; Salem Chouaib; Jean-Paul Thiery; Christian Muchardt; Michèle Sabbah; Annette K Larsen
Journal:  Oncotarget       Date:  2015-07-30

4.  MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines.

Authors:  Pasqualino de Antonellis; Lucia Liguori; Annarita Falanga; Marianeve Carotenuto; Veronica Ferrucci; Immacolata Andolfo; Federica Marinaro; Immacolata Scognamiglio; Antonella Virgilio; Giuseppe De Rosa; Aldo Galeone; Stefania Galdiero; Massimo Zollo
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-01-26       Impact factor: 3.000

5.  CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer.

Authors:  Mark L McCleland; Kathryn Mesh; Edward Lorenzana; Vivek S Chopra; Ehud Segal; Colin Watanabe; Benjamin Haley; Oleg Mayba; Murat Yaylaoglu; Florian Gnad; Ron Firestein
Journal:  J Clin Invest       Date:  2016-01-11       Impact factor: 14.808

6.  Advanced glycosylation end product promotes forkhead box O1 and inhibits Wnt pathway to suppress capacities of epidermal stem cells.

Authors:  Jie Zhu; Peng Wang; Zhimin Yu; Wei Lai; Yi Cao; Pinbo Huang; Qiaodong Xu; Menglei Yu; Junyao Xu; Zitong Huang; Bing Zeng
Journal:  Am J Transl Res       Date:  2016-12-15       Impact factor: 4.060

Review 7.  Can we safely target the WNT pathway?

Authors:  Michael Kahn
Journal:  Nat Rev Drug Discov       Date:  2014-07       Impact factor: 84.694

8.  Osteogenic differentiation potential of adipose-derived stem cells from ovariectomized mice.

Authors:  Lei Wang; Chenglong Huang; Qing Li; Xiaomei Xu; Lin Liu; Kui Huang; Xiaoxiao Cai; Jingang Xiao
Journal:  Cell Prolif       Date:  2017-01-16       Impact factor: 6.831

9.  The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β.

Authors:  Alessandro Dema; Micha Friedemann Schröter; Ekaterina Perets; Philipp Skroblin; Marie Christine Moutty; Veronika Anita Deàk; Walter Birchmeier; Enno Klussmann
Journal:  J Biol Chem       Date:  2016-08-02       Impact factor: 5.157

10.  Antagonism between Hedgehog and Wnt signaling pathways regulates tumorigenicity.

Authors:  Mei Ding; Xin Wang
Journal:  Oncol Lett       Date:  2017-09-22       Impact factor: 2.967
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