Literature DB >> 26418764

What if stem cells turn into embryos in a dish?

Martin F Pera1,2,3, Guido de Wert4, Wybo Dondorp4, Robin Lovell-Badge5, Christine L Mummery6, Megan Munsie1, Patrick P Tam7,8.   

Abstract

Recent studies show that pluripotent stem cells can undergo self-organized development in vitro into structures that mimic the body plan of the post-implantation embryo. Modeling human embryogenesis in a dish opens up new possibilities for the study of early development and developmental disorders, but it may also raise substantial ethical concerns.

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Year:  2015        PMID： 26418764     DOI： 10.1038/nmeth.3586

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  10 in total

1.  Culture of whole mouse embryos at early postimplantation to organogenesis stages: developmental staging and methods.

Authors:  Jaime A Rivera-Pérez; Vanessa Jones; Patrick P L Tam
Journal:  Methods Enzymol       Date:  2010       Impact factor: 1.600

Review 2.  Gene function in mouse embryogenesis: get set for gastrulation.

Authors:  Patrick P L Tam; David A F Loebel
Journal:  Nat Rev Genet       Date:  2007-03-27       Impact factor: 53.242

3.  Pax6 is a human neuroectoderm cell fate determinant.

Authors:  Xiaoqing Zhang; Cindy T Huang; Jing Chen; Matthew T Pankratz; Jiajie Xi; Jin Li; Ying Yang; Timothy M Lavaute; Xue-Jun Li; Melvin Ayala; Gennadiy I Bondarenko; Zhong-Wei Du; Ying Jin; Thaddeus G Golos; Su-Chun Zhang
Journal:  Cell Stem Cell       Date:  2010-07-02       Impact factor: 24.633

Review 4.  Organogenesis in a dish: modeling development and disease using organoid technologies.

Authors:  Madeline A Lancaster; Juergen A Knoblich
Journal:  Science       Date:  2014-07-17       Impact factor: 47.728

5.  Transcriptional analysis of early lineage commitment in human embryonic stem cells.

Authors:  Andrew L Laslett; Sean Grimmond; Brooke Gardiner; Lincon Stamp; Adelia Lin; Susan M Hawes; Sam Wormald; David Nikolic-Paterson; David Haylock; Martin F Pera
Journal:  BMC Dev Biol       Date:  2007-03-02       Impact factor: 1.978

6.  A method for human teratogen detection by geometrically confined cell differentiation and migration.

Authors:  Jiangwa Xing; Yi-Chin Toh; Shuoyu Xu; Hanry Yu
Journal:  Sci Rep       Date:  2015-05-12       Impact factor: 4.379

7.  SOX17 is a critical specifier of human primordial germ cell fate.

Authors:  Naoko Irie; Leehee Weinberger; Walfred W C Tang; Toshihiro Kobayashi; Sergey Viukov; Yair S Manor; Sabine Dietmann; Jacob H Hanna; M Azim Surani
Journal:  Cell       Date:  2014-12-24       Impact factor: 41.582

8.  Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells.

Authors:  Susanne C van den Brink; Peter Baillie-Johnson; Tina Balayo; Anna-Katerina Hadjantonakis; Sonja Nowotschin; David A Turner; Alfonso Martinez Arias
Journal:  Development       Date:  2014-11       Impact factor: 6.868

9.  A method to recapitulate early embryonic spatial patterning in human embryonic stem cells.

Authors:  Aryeh Warmflash; Benoit Sorre; Fred Etoc; Eric D Siggia; Ali H Brivanlou
Journal:  Nat Methods       Date:  2014-06-29       Impact factor: 28.547

10.  Single-cell gene expression profiles define self-renewing, pluripotent, and lineage primed states of human pluripotent stem cells.

Authors:  Shelley R Hough; Matthew Thornton; Elizabeth Mason; Jessica C Mar; Christine A Wells; Martin F Pera
Journal:  Stem Cell Reports       Date:  2014-05-22       Impact factor: 7.765
  10 in total
  22 in total

1.  The moral status of human embryo-like structures: potentiality matters?: The moral status of human synthetic embryos.

Authors:  Tsutomu Sawai; Tomohiro Minakawa; Jonathan Pugh; Kyoko Akatsuka; Jun K Yamashita; Misao Fujita
Journal:  EMBO Rep       Date:  2020-07-27       Impact factor: 8.807

2.  Human embryos grown in lab for longer than ever before.

Authors:  Sara Reardon
Journal:  Nature       Date:  2016-05-05       Impact factor: 49.962

3.  Embryology policy: Revisit the 14-day rule.

Authors:  Insoo Hyun; Amy Wilkerson; Josephine Johnston
Journal:  Nature       Date:  2016-05-12       Impact factor: 49.962

Review 4.  The rise of three-dimensional human brain cultures.

Authors:  Sergiu P Pașca
Journal:  Nature       Date:  2018-01-24       Impact factor: 49.962

5.  Responsible innovation in human germline gene editing: Background document to the recommendations of ESHG and ESHRE.

Authors:  Guido De Wert; Björn Heindryckx; Guido Pennings; Angus Clarke; Ursula Eichenlaub-Ritter; Carla G van El; Francesca Forzano; Mariëtte Goddijn; Heidi C Howard; Dragica Radojkovic; Emmanuelle Rial-Sebbag; Wybo Dondorp; Basil C Tarlatzis; Martina C Cornel
Journal:  Eur J Hum Genet       Date:  2018-01-12       Impact factor: 4.246

6.  Ethical Challenges in Organoid Use.

Authors:  Vasiliki Mollaki
Journal:  BioTech (Basel)       Date:  2021-06-28

Review 7.  Biomedical and societal impacts of in vitro embryo models of mammalian development.

Authors:  Naomi Moris; Cantas Alev; Martin Pera; Alfonso Martinez Arias
Journal:  Stem Cell Reports       Date:  2021-05-11       Impact factor: 7.765

Review 8.  Self-Organization of Stem Cell Colonies and of Early Mammalian Embryos: Recent Experiments Shed New Light on the Role of Autonomy vs. External Instructions in Basic Body Plan Development.

Authors:  Hans-Werner Denker
Journal:  Cells       Date:  2016-10-25       Impact factor: 6.600

Review 9.  Organoids and the genetically encoded self-assembly of embryonic stem cells.

Authors:  David A Turner; Peter Baillie-Johnson; Alfonso Martinez Arias
Journal:  Bioessays       Date:  2015-12-15       Impact factor: 4.345

10.  Self-organization of the human embryo in the absence of maternal tissues.

Authors:  Marta N Shahbazi; Agnieszka Jedrusik; Sanna Vuoristo; Gaelle Recher; Anna Hupalowska; Virginia Bolton; Norah N M Fogarty; Alison Campbell; Liani Devito; Dusko Ilic; Yakoub Khalaf; Kathy K Niakan; Simon Fishel; Magdalena Zernicka-Goetz
Journal:  Nat Cell Biol       Date:  2016-05-04       Impact factor: 28.824
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