Literature DB >> 26416854

Fitness Studies of Azole-Resistant Strains of Aspergillus fumigatus.

Isabel Valsecchi1, Emilia Mellado2, Rémi Beau1, Shriya Raj1, Jean-Paul Latgé3.   

Abstract

Isogenic bar-coded strains of Aspergillus fumigatus carrying the G54W or M220K mutation in Cyp51A were constructed. In vitro, the growth and conidiation capacities of the mutants were similar to those of the parental strain. Competition studies in the absence of azoles showed that there was no adverse fitness cost for the azole-resistant A. fumigatus strains in vitro or in vivo compared to the parental strain.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26416854      PMCID： PMC4649223          DOI： 10.1128/AAC.01594-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  28 in total

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Authors:  Marcin G Fraczek; Michael Bromley; Ahmed Buied; Caroline B Moore; Ranjith Rajendran; Riina Rautemaa; Gordon Ramage; David W Denning; Paul Bowyer
Journal:  J Antimicrob Chemother       Date:  2013-04-10       Impact factor: 5.790

2.  Fluconazole versus Candida albicans: a complex relationship.

Authors:  J R Graybill; E Montalbo; W R Kirkpatrick; M F Luther; S G Revankar; T F Patterson
Journal:  Antimicrob Agents Chemother       Date:  1998-11       Impact factor: 5.191

3.  Effect of DMI-resistance mechanisms on cross-resistance patterns, fitness parameters and aflatoxin production in Aspergillus parasiticus Speare.

Authors:  Eleftherios G Doukas; Anastasios N Markoglou; John G Vontas; Basil N Ziogas
Journal:  Fungal Genet Biol       Date:  2012-08-11       Impact factor: 3.495

4.  Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence.

Authors:  Maiken Cavling Arendrup; Eleftheria Mavridou; Klaus Leth Mortensen; Eveline Snelders; Niels Frimodt-Møller; Humara Khan; Willem J G Melchers; Paul E Verweij
Journal:  PLoS One       Date:  2010-04-09       Impact factor: 3.240

5.  Distinct roles of Candida albicans drug resistance transcription factors TAC1, MRR1, and UPC2 in virulence.

Authors:  Andrea Lohberger; Alix T Coste; Dominique Sanglard
Journal:  Eukaryot Cell       Date:  2013-11-15

6.  Composite survival index to compare virulence changes in azole-resistant Aspergillus fumigatus clinical isolates.

Authors:  Eleftheria Mavridou; Joseph Meletiadis; Pavol Jancura; Saiden Abbas; Maiken C Arendrup; Willem J G Melchers; Tom Heskes; Johan W Mouton; Paul E Verweij
Journal:  PLoS One       Date:  2013-08-26       Impact factor: 3.240

7.  An invertebrate model to evaluate virulence in Aspergillus fumigatus: the role of azole resistance.

Authors:  A Gomez-Lopez; A Forastiero; E Cendejas-Bueno; L Gregson; E Mellado; S J Howard; J L Livermore; W W Hope; M Cuenca-Estrella
Journal:  Med Mycol       Date:  2014-02-04       Impact factor: 4.076

8.  Ergosterol biosynthesis in Aspergillus fumigatus: its relevance as an antifungal target and role in antifungal drug resistance.

Authors:  Laura Alcazar-Fuoli; Emilia Mellado
Journal:  Front Microbiol       Date:  2013-01-10       Impact factor: 5.640

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Authors:  Eveline Snelders; Henrich A L van der Lee; Judith Kuijpers; Anthonius J M M Rijs; János Varga; Robert A Samson; Emilia Mellado; A Rogier T Donders; Willem J G Melchers; Paul E Verweij
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10.  Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance.

Authors:  Anna M Selmecki; Keely Dulmage; Leah E Cowen; James B Anderson; Judith Berman
Journal:  PLoS Genet       Date:  2009-10-30       Impact factor: 5.917
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  12 in total

Review 1.  Clinical implications of globally emerging azole resistance in Aspergillus fumigatus.

Authors:  Jacques F Meis; Anuradha Chowdhary; Johanna L Rhodes; Matthew C Fisher; Paul E Verweij
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2016-12-05       Impact factor: 6.237

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Review 3.  Aspergillus fumigatus and Aspergillosis in 2019.

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Journal:  Clin Microbiol Rev       Date:  2019-11-13       Impact factor: 26.132

Review 4.  Molecular Tools for the Detection and Deduction of Azole Antifungal Drug Resistance Phenotypes in Aspergillus Species.

Authors:  Anna Dudakova; Birgit Spiess; Marut Tangwattanachuleeporn; Christoph Sasse; Dieter Buchheidt; Michael Weig; Uwe Groß; Oliver Bader
Journal:  Clin Microbiol Rev       Date:  2017-10       Impact factor: 26.132

Review 5.  Therapeutic Drug Monitoring of Posaconazole: an Update.

Authors:  Bart G J Dekkers; Martijn Bakker; Kim C M van der Elst; Marieke G G Sturkenboom; Anette Veringa; Lambert F R Span; Jan-Willem C Alffenaar
Journal:  Curr Fungal Infect Rep       Date:  2016-05-07

Review 6.  Ecology of aspergillosis: insights into the pathogenic potency of Aspergillus fumigatus and some other Aspergillus species.

Authors:  Caroline Paulussen; John E Hallsworth; Sergio Álvarez-Pérez; William C Nierman; Philip G Hamill; David Blain; Hans Rediers; Bart Lievens
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7.  Phylogenetic Distribution of csp1 Types in Aspergillus fumigatus and Their Correlates to Azole Antifungal Drug Resistance.

Authors:  Oliver Bader
Journal:  Microbiol Spectr       Date:  2021-11-17

8.  Clinical and experimental phenotype of azole-resistant Aspergillus fumigatus with a HapE splice site mutation: a case report.

Authors:  Yuya Ito; Takahiro Takazono; Satoru Koga; Yuichiro Nakano; Nobuyuki Ashizawa; Tatsuro Hirayama; Masato Tashiro; Tomomi Saijo; Kazuko Yamamoto; Yoshifumi Imamura; Taiga Miyazaki; Katsunori Yanagihara; Koichi Izumikawa; Hiroshi Mukae
Journal:  BMC Infect Dis       Date:  2021-06-14       Impact factor: 3.090

9.  In-host microevolution of Aspergillus fumigatus: A phenotypic and genotypic analysis.

Authors:  Eloise Ballard; Willem J G Melchers; Jan Zoll; Alistair J P Brown; Paul E Verweij; Adilia Warris
Journal:  Fungal Genet Biol       Date:  2018-02-23       Impact factor: 3.495

10.  In Vivo Efficacy of Voriconazole in a Galleria mellonella Model of Invasive Infection Due to Azole-Susceptible or Resistant Aspergillus fumigatus Isolates.

Authors:  Sana Jemel; Jacques Guillot; Kalthoum Kallel; Grégory Jouvion; Elise Brisebard; Eliane Billaud; Vincent Jullien; Françoise Botterel; Eric Dannaoui
Journal:  J Fungi (Basel)       Date:  2021-11-26
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