Literature DB >> 27795873

Chloroquine-Containing HPMA Copolymers as Polymeric Inhibitors of Cancer Cell Migration Mediated by the CXCR4/SDF-1 Chemokine Axis.

Fei Yu1, Ying Xie1, Yan Wang1, Zheng-Hong Peng1, Jing Li1, David Oupický1.   

Abstract

Chloroquine-containing HPMA copolymers (pCQs) were synthesized for the first time by copolymerization of methacryloylated hydroxychloroquine and HPMA. The copolymers showed lower cytotoxicity when compared with hydroxychloroquine. Treatment of cancer cells with pCQ resulted in decreased surface expression of chemokine receptor CXCR4. The pCQ copolymers showed effective inhibition of CXCR4/SDF1-mediated cancer cell migration that was fully comparable with a commercial small-molecule CXCR4 antagonist AMD3100. The reported pCQ represent unique and simple polymeric drugs with potential use as part of a combination antimetastatic therapies.

Entities:  

Year:  2016        PMID： 27795873      PMCID： PMC5084841          DOI： 10.1021/acsmacrolett.5b00857

Source DB:  PubMed          Journal:  ACS Macro Lett            Impact factor:   6.903


  26 in total

Review 1.  Targeting bacterial toxins.

Authors:  Mattias E Ivarsson; Jean-Christophe Leroux; Bastien Castagner
Journal:  Angew Chem Int Ed Engl       Date:  2012-03-22       Impact factor: 15.336

Review 2.  The chemokine system and cancer.

Authors:  Frances R Balkwill
Journal:  J Pathol       Date:  2011-11-23       Impact factor: 7.996

Review 3.  New pharmaceutical applications for macromolecular binders.

Authors:  Nicolas Bertrand; Marc A Gauthier; Céline Bouvet; Pierre Moreau; Anne Petitjean; Jean-Christophe Leroux; Jeanne Leblond
Journal:  J Control Release       Date:  2011-05-05       Impact factor: 9.776

Review 4.  The role of autophagy in cancer: therapeutic implications.

Authors:  Zhineng J Yang; Cheng E Chee; Shengbing Huang; Frank A Sinicrope
Journal:  Mol Cancer Ther       Date:  2011-08-30       Impact factor: 6.261

Review 5.  Molecular Pathways: Targeting the CXCR4-CXCL12 Axis--Untapped Potential in the Tumor Microenvironment.

Authors:  Stefania Scala
Journal:  Clin Cancer Res       Date:  2015-07-21       Impact factor: 12.531

6.  Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype.

Authors:  Sergej Konoplev; Georgios Z Rassidakis; Elihu Estey; Hagop Kantarjian; Chrysoula I Liakou; Xuelin Huang; Lianchun Xiao; Michael Andreeff; Marina Konopleva; L Jeffrey Medeiros
Journal:  Cancer       Date:  2007-03-15       Impact factor: 6.860

Review 7.  Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies.

Authors:  V Raja Solomon; Hoyun Lee
Journal:  Eur J Pharmacol       Date:  2009-10-15       Impact factor: 4.432

8.  Effect of biodegradability on CXCR4 antagonism, transfection efficacy and antimetastatic activity of polymeric Plerixafor.

Authors:  Jing Li; David Oupický
Journal:  Biomaterials       Date:  2014-04-13       Impact factor: 12.479

9.  The chemotherapeutic potential of PEG-b-PLGA copolymer micelles that combine chloroquine as autophagy inhibitor and docetaxel as an anti-cancer drug.

Authors:  Xudong Zhang; Xiaowei Zeng; Xin Liang; Ying Yang; Xiaoming Li; Hongbo Chen; Laiqiang Huang; Lin Mei; Si-Shen Feng
Journal:  Biomaterials       Date:  2014-08-07       Impact factor: 12.479

10.  HPMA copolymers: origins, early developments, present, and future.

Authors:  Jindrich Kopecek; Pavla Kopecková
Journal:  Adv Drug Deliv Rev       Date:  2009-11-14       Impact factor: 15.470
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  7 in total

1.  Synthesis and Evaluation of Chloroquine-Containing DMAEMA Copolymers as Efficient Anti-miRNA Delivery Vectors with Improved Endosomal Escape and Antimigratory Activity in Cancer Cells.

Authors:  Ying Xie; Fei Yu; Weimin Tang; Bolutito Oluwole Alade; Zheng-Hong Peng; Yazhe Wang; Jing Li; David Oupický
Journal:  Macromol Biosci       Date:  2017-08-04       Impact factor: 4.979

2.  Chloroquine-Modified Hydroxyethyl Starch as a Polymeric Drug for Cancer Therapy.

Authors:  Richard Sleightholm; Bin Yang; Fei Yu; Ying Xie; David Oupický
Journal:  Biomacromolecules       Date:  2017-07-14       Impact factor: 6.988

3.  Polymeric chloroquine as an inhibitor of cancer cell migration and experimental lung metastasis.

Authors:  Fei Yu; Jing Li; Ying Xie; Richard L Sleightholm; David Oupický
Journal:  J Control Release       Date:  2016-07-27       Impact factor: 9.776

Review 4.  Promise of chemokine network-targeted nanoparticles in combination nucleic acid therapies of metastatic cancer.

Authors:  Ying Xie; Yazhe Wang; Jing Li; Yu Hang; David Oupický
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2018-04-26

5.  Association of CXCL13 and Immune Cell Infiltration Signature in Clear Cell Renal Cell Carcinoma.

Authors:  Fangdong Jiao; Hao Sun; Qingya Yang; Hui Sun; Zehua Wang; Ming Liu; Jun Chen
Journal:  Int J Med Sci       Date:  2020-06-27       Impact factor: 3.738

Review 6.  A Review of Modifications of Quinoline Antimalarials: Mefloquine and (hydroxy)Chloroquine.

Authors:  Dawid J Kucharski; Michalina K Jaszczak; Przemysław J Boratyński
Journal:  Molecules       Date:  2022-02-02       Impact factor: 4.411

7.  Quinine copolymer reporters promote efficient intracellular DNA delivery and illuminate a protein-induced unpackaging mechanism.

Authors:  Craig Van Bruggen; David Punihaole; Allison R Keith; Andrew J Schmitz; Jakub Tolar; Renee R Frontiera; Theresa M Reineke
Journal:  Proc Natl Acad Sci U S A       Date:  2020-12-14       Impact factor: 12.779
  7 in total

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