Sergio Davinelli1, Juan Carlos Bertoglio2, Armando Zarrelli3, Riccardo Pina4, Giovanni Scapagnini1,5. 1. a Department of Medicine and Health Sciences , University of Molise , Campobasso , ITALY. 2. b Department of Medicine , Hospital Clinico Regional de Valdivia , Valdivia , CHILE. 3. c Department of Chemical Sciences , University of Napoli 'Federico II , Napoli , ITALY. 4. d Equipe Enervit Srl , Scientific Unit of Enervit Spa , Milano , ITALY. 5. e Inter-University Consortium "SannioTech" , Apollosa ( BN ), ITALY.
Abstract
OBJECTIVE: Berries are a rich source of anthocyanins, and clinical data suggest that a polyphenol-rich diet may exert health-promoting effects by reducing oxidative stress. The aim of this study was to elucidate the effects of dietary supplementation with Delphinol (trademark owned by MNL Chile) standardized maqui berry (Aristotelia chilensis) extract on products of lipid peroxidation in healthy, overweight, and smoker subjects. METHODS: In a double-blind, placebo-controlled design, 42 participants (age 45-65 years) consumed in random order either a standardized extract of maqui berry (162 mg anthocyanins) or a matched placebo, given 3 times daily for 4 weeks. The samples were collected at baseline, after the end of the supplementation, and 40 days after the end of the study. Primary outcome was the measure of oxidized low-density lipoprotein (Ox-LDL) and F2-isoprostanes in plasma and urine, respectively. Secondary outcomes included anthropometric measures, blood pressure, and lipid profile. RESULTS:Delphinol supplementation was associated with reduced levels of Ox-LDL in the anthocyanin group compared to baseline (p < 0.05). There was also a decrease in urinary F2-isoprostanes (8-iso-prostaglandin F2α) at 4 weeks versus baseline in the Delphinol-supplemented group (p < 0.05). However, no differences in primary outcomes were evident at 40 days of follow-up. In the fourth week of the intervention, no significant differences were noted for anthropometric characteristics, ambulatory blood pressure, and lipid profile. CONCLUSIONS: Our observations suggest that dietary interventions with maqui berry extract may improve oxidative status (Ox-LDL and F2-isoprostanes) in healthy adults, overweight adults, and adult smokers.
RCT Entities:
OBJECTIVE: Berries are a rich source of anthocyanins, and clinical data suggest that a polyphenol-rich diet may exert health-promoting effects by reducing oxidative stress. The aim of this study was to elucidate the effects of dietary supplementation with Delphinol (trademark owned by MNL Chile) standardized maqui berry (Aristotelia chilensis) extract on products of lipid peroxidation in healthy, overweight, and smoker subjects. METHODS: In a double-blind, placebo-controlled design, 42 participants (age 45-65 years) consumed in random order either a standardized extract of maqui berry (162 mg anthocyanins) or a matched placebo, given 3 times daily for 4 weeks. The samples were collected at baseline, after the end of the supplementation, and 40 days after the end of the study. Primary outcome was the measure of oxidized low-density lipoprotein (Ox-LDL) and F2-isoprostanes in plasma and urine, respectively. Secondary outcomes included anthropometric measures, blood pressure, and lipid profile. RESULTS: Delphinol supplementation was associated with reduced levels of Ox-LDL in the anthocyanin group compared to baseline (p < 0.05). There was also a decrease in urinary F2-isoprostanes (8-iso-prostaglandin F2α) at 4 weeks versus baseline in the Delphinol-supplemented group (p < 0.05). However, no differences in primary outcomes were evident at 40 days of follow-up. In the fourth week of the intervention, no significant differences were noted for anthropometric characteristics, ambulatory blood pressure, and lipid profile. CONCLUSIONS: Our observations suggest that dietary interventions with maqui berry extract may improve oxidative status (Ox-LDL and F2-isoprostanes) in healthy adults, overweight adults, and adult smokers.
Authors: Arrigo F G Cicero; Alessandro Colletti; Gani Bajraktari; Olivier Descamps; Dragan M Djuric; Marat Ezhov; Zlatko Fras; Niki Katsiki; Michel Langlois; Gustavs Latkovskis; Demosthenes B Panagiotakos; Gyorgy Paragh; Dimitri P Mikhailidis; Olena Mitchenko; Bernhard Paulweber; Daniel Pella; Christos Pitsavos; Željko Reiner; Kausik K Ray; Manfredi Rizzo; Amirhossein Sahebkar; Maria-Corina Serban; Laurence S Sperling; Peter P Toth; Dragos Vinereanu; Michal Vrablík; Nathan D Wong; Maciej Banach Journal: Arch Med Sci Date: 2017-08-04 Impact factor: 3.318