| Literature DB >> 26399828 |
Alejandro De Los Angeles1,2,3, Francesco Ferrari4, Ruibin Xi4,5, Yuko Fujiwara1,2,3, Nissim Benvenisty6, Hongkui Deng7, Konrad Hochedlinger2,3,4,8, Rudolf Jaenisch9, Soohyun Lee4, Harry G Leitch10, M William Lensch1,2,3, Ernesto Lujan11, Duanqing Pei12, Janet Rossant13, Marius Wernig11, Peter J Park4, George Q Daley1,2,3.
Abstract
Stem cells self-renew and generate specialized progeny through differentiation, but vary in the range of cells and tissues they generate, a property called developmental potency. Pluripotent stem cells produce all cells of an organism, while multipotent or unipotent stem cells regenerate only specific lineages or tissues. Defining stem-cell potency relies upon functional assays and diagnostic transcriptional, epigenetic and metabolic states. Here we describe functional and molecular hallmarks of pluripotent stem cells, propose a checklist for their evaluation, and illustrate how forensic genomics can validate their provenance.Mesh:
Year: 2015 PMID: 26399828 DOI: 10.1038/nature15515
Source DB: PubMed Journal: Nature ISSN: 0028-0836 Impact factor: 49.962