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Literature DB >> 26391637

mTOR in health and in sickness.

Abstract

Target of rapamycin (TOR) is a highly conserved protein kinase that plays a key role in mediating cell growth and homeostasis. It is activated by nutrients, growth factors, and cellular energy levels to control a number of anabolic and catabolic processes. It is a validated drug target implicated in a variety of diseases. In this review, we describe the molecular mode of action of TOR in the context of cellular and organismal physiology. We focus on mammalian TOR (mTOR) signaling in cancer and neurological disease and discuss usage of TOR inhibitors in the clinic.

Entities: Chemical Disease Gene Species

Keywords: Disease; Health; Rapalogs; Rapamycin; TOR; mTOR; mTOR inhibitors; mTORC1; mTORC2

Mesh：

Substances：

Year: 2015 PMID： 26391637 DOI： 10.1007/s00109-015-1326-7

Source DB: PubMed Journal: J Mol Med (Berl) ISSN： 0946-2716 Impact factor: 4.599

177 in total

1. mTORC1 directly phosphorylates and regulates human MAF1.

Authors: Annemieke A Michels; Aaron M Robitaille; Diane Buczynski-Ruchonnet; Wassim Hodroj; Jaime H Reina; Michael N Hall; Nouria Hernandez
Journal: Mol Cell Biol Date: 2010-06-01 Impact factor: 4.272

2. Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits.

Authors: Guomei Tang; Kathryn Gudsnuk; Sheng-Han Kuo; Marisa L Cotrina; Gorazd Rosoklija; Alexander Sosunov; Mark S Sonders; Ellen Kanter; Candace Castagna; Ai Yamamoto; Zhenyu Yue; Ottavio Arancio; Bradley S Peterson; Frances Champagne; Andrew J Dwork; James Goldman; David Sulzer
Journal: Neuron Date: 2014-08-21 Impact factor: 17.173

Review 3. The neurology of mTOR.

Authors: Jonathan O Lipton; Mustafa Sahin
Journal: Neuron Date: 2014-10-22 Impact factor: 17.173

4. Mechanism of activation of protein kinase B by insulin and IGF-1.

Authors: D R Alessi; M Andjelkovic; B Caudwell; P Cron; N Morrice; P Cohen; B A Hemmings
Journal: EMBO J Date: 1996-12-02 Impact factor: 11.598

5. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.

Authors: J Choi; J Chen; S L Schreiber; J Clardy
Journal: Science Date: 1996-07-12 Impact factor: 47.728

6. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression.

Authors: J Kunz; R Henriquez; U Schneider; M Deuter-Reinhard; N R Movva; M N Hall
Journal: Cell Date: 1993-05-07 Impact factor: 41.582

7. Carbamoyl phosphate synthetase (glutamine-hydrolyzing): increased activity in cancer cells.

Authors: T Aoki; G Weber
Journal: Science Date: 1981-04-24 Impact factor: 47.728

8. Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice.

Authors: Aditi Bhattacharya; Hanoch Kaphzan; Amanda C Alvarez-Dieppa; Jaclyn P Murphy; Philippe Pierre; Eric Klann
Journal: Neuron Date: 2012-10-17 Impact factor: 17.173

9. Structure of the human mTOR complex I and its implications for rapamycin inhibition.

Authors: Calvin K Yip; Kazuyoshi Murata; Thomas Walz; David M Sabatini; Seong A Kang
Journal: Mol Cell Date: 2010-06-11 Impact factor: 17.970

10. Autophagy as a new therapeutic target in Duchenne muscular dystrophy.

Authors: C De Palma; F Morisi; S Cheli; S Pambianco; V Cappello; M Vezzoli; P Rovere-Querini; M Moggio; M Ripolone; M Francolini; M Sandri; E Clementi
Journal: Cell Death Dis Date: 2012-11-15 Impact factor: 8.469

25 in total

Review 1. Nutrient sensing and TOR signaling in yeast and mammals.

Authors: Asier González; Michael N Hall
Journal: EMBO J Date: 2017-01-17 Impact factor: 11.598

Review 2. Cross-talk between protein synthesis, energy metabolism and autophagy in cancer.

Authors: Lisa M Lindqvist; Kristofferson Tandoc; Ivan Topisirovic; Luc Furic
Journal: Curr Opin Genet Dev Date: 2017-11-25 Impact factor: 5.578

Review 3. Mammalian Target of Rapamycin: A Target for (Lung) Diseases and Aging.

Authors: Brian K Kennedy; Juniper K Pennypacker
Journal: Ann Am Thorac Soc Date: 2016-12

Review 4. Recent Discoveries on the Role of TOR (Target of Rapamycin) Signaling in Translation in Plants.

Authors: Mikhail Schepetilnikov; Lyubov A Ryabova
Journal: Plant Physiol Date: 2017-11-09 Impact factor: 8.340

5. Proteomic changes of CD4⁺/CD25⁺/forkhead box p3⁺ regulatory T cells in a 30-day rat model of sepsis survival.

Authors: Yuxia Jiao; Siqi Tan; Junyu Xiong
Journal: Exp Ther Med Date: 2017-09-29 Impact factor: 2.447

6. Loss of TSC complex enhances gluconeogenesis via upregulation of Dlk1-Dio3 locus miRNAs.

Authors: Dritan Liko; Andrzej Rzepiela; Vanja Vukojevic; Mihaela Zavolan; Michael N Hall
Journal: Proc Natl Acad Sci U S A Date: 2020-01-09 Impact factor: 11.205

7. The Aspergillus fumigatus SchA^SCH9 kinase modulates SakA^HOG1 MAP kinase activity and it is essential for virulence.

Authors: Patrícia Alves de Castro; Thaila Fernanda Dos Reis; Stephen K Dolan; Adriana Oliveira Manfiolli; Neil Andrew Brown; Gary W Jones; Sean Doyle; Diego M Riaño-Pachón; Fábio Márcio Squina; Camila Caldana; Ashutosh Singh; Maurizio Del Poeta; Daisuke Hagiwara; Rafael Silva-Rocha; Gustavo H Goldman
Journal: Mol Microbiol Date: 2016-10-07 Impact factor: 3.501

8. Targeting AMPK, mTOR and β-Catenin by Combined Metformin and Aspirin Therapy in HCC: An Appraisal in Egyptian HCC Patients.

Authors: Doaa Ali Abdelmonsif; Ahmed S Sultan; Wessam F El-Hadidy; Dina Mohamed Abdallah
Journal: Mol Diagn Ther Date: 2018-02 Impact factor: 4.074

Review 9. Melanocytic nevi and melanoma: unraveling a complex relationship.

Authors: W E Damsky; M Bosenberg
Journal: Oncogene Date: 2017-06-12 Impact factor: 9.867

10. Mitogenic signaling pathways in the liver of growth hormone (GH)-overexpressing mice during the growth period.

Authors: Carolina S Martinez; Verónica G Piazza; Lorena González; Yimin Fang; Andrzej Bartke; Daniel Turyn; Johanna G Miquet; Ana I Sotelo
Journal: Cell Cycle Date: 2016 Impact factor: 4.534