| Literature DB >> 26385796 |
Cara E Pugliese1, Lauren Kenworthy2, Vanessa Hus Bal3, Gregory L Wallace4,5, Benjamin E Yerys6,7, Brenna B Maddox6,8, Susan W White8, Haroon Popal5, Anna Chelsea Armour2, Judith Miller6,7, John D Herrington6,7, Robert T Schultz6,9, Alex Martin5, Laura Gutermuth Anthony2.
Abstract
Recent updates have been proposed to the Autism Diagnostic Observation Schedule-2 Module 4 diagnostic algorithm. This new algorithm, however, has not yet been validated in an independent sample without intellectual disability (ID). This multi-site study compared the original and revised algorithms in individuals with ASD without ID. The revised algorithm demonstrated increased sensitivity, but lower specificity in the overall sample. Estimates were highest for females, individuals with a verbal IQ below 85 or above 115, and ages 16 and older. Best practice diagnostic procedures should include the Module 4 in conjunction with other assessment tools. Balancing needs for sensitivity and specificity depending on the purpose of assessment (e.g., clinical vs. research) and demographic characteristics mentioned above will enhance its utility.Entities:
Keywords: Adolescents; Adults; Autism diagnostic observation schedule; Autism spectrum disorder; Diagnosis; Sensitivity; Specificity
Mesh：
Year: 2015 PMID： 26385796 PMCID： PMC4654671 DOI： 10.1007/s10803-015-2586-3
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257