Literature DB >> 26384661

SPOP Mutations or ERG Rearrangements Result in Enhanced Levels of ERG to Promote Cell Invasion in Prostate Cancer.

Shanshan Duan1, Michele Pagano2.   

Abstract

In this issue, An et al. (2015) and Gan et al. (2015) reveal that the CRL3(SPOP) ubiquitin ligase mediates the degradation of the transcription factor ERG and that translocations of ERG or mutations in SPOP prevent CRL3(SPOP)-dependent degradation of ERG in prostate cancer cells.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26384661      PMCID： PMC4948578          DOI： 10.1016/j.molcel.2015.09.003

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  11 in total

Review 1.  SCF ubiquitin ligase-targeted therapies.

Authors:  Jeffrey R Skaar; Julia K Pagan; Michele Pagano
Journal:  Nat Rev Drug Discov       Date:  2014-11-14       Impact factor: 84.694

2.  Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer.

Authors:  Jean-Philippe P Theurillat; Namrata D Udeshi; Wesley J Errington; Tanya Svinkina; Sylvan C Baca; Marius Pop; Peter J Wild; Mirjam Blattner; Anna C Groner; Mark A Rubin; Holger Moch; Gilbert G Prive; Steven A Carr; Levi A Garraway
Journal:  Science       Date:  2014-10-02       Impact factor: 47.728

Review 3.  Function and regulation of cullin-RING ubiquitin ligases.

Authors:  Matthew D Petroski; Raymond J Deshaies
Journal:  Nat Rev Mol Cell Biol       Date:  2005-01       Impact factor: 94.444

Review 4.  Clinical potential of the ERG oncoprotein in prostate cancer.

Authors:  Philip Rosen; Isabell A Sesterhenn; Stephen A Brassell; David G McLeod; Shiv Srivastava; Albert Dobi
Journal:  Nat Rev Urol       Date:  2012-02-14       Impact factor: 14.432

Review 5.  The emerging role of speckle-type POZ protein (SPOP) in cancer development.

Authors:  Ram-Shankar Mani
Journal:  Drug Discov Today       Date:  2014-07-21       Impact factor: 7.851

Review 6.  The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications.

Authors:  Pascal Genschik; Izabela Sumara; Esther Lechner
Journal:  EMBO J       Date:  2013-08-02       Impact factor: 11.598

7.  Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation.

Authors:  Jian An; Shancheng Ren; Stephen J Murphy; Sumiya Dalangood; Cunjie Chang; Xiaodong Pang; Yangyan Cui; Liguo Wang; Yunqian Pan; Xiaowei Zhang; Yasheng Zhu; Chenji Wang; Geoffrey C Halling; Liang Cheng; William R Sukov; R Jeffrey Karnes; George Vasmatzis; Qing Zhang; Jun Zhang; John C Cheville; Jun Yan; Yinghao Sun; Haojie Huang
Journal:  Mol Cell       Date:  2015-09-03       Impact factor: 17.970

8.  SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.

Authors:  Wenjian Gan; Xiangpeng Dai; Andrea Lunardi; Zhen Li; Hiroyuki Inuzuka; Pengda Liu; Shoreh Varmeh; Jinfang Zhang; Liang Cheng; Yin Sun; John M Asara; Andrew H Beck; Jiaoti Huang; Pier Paolo Pandolfi; Wenyi Wei
Journal:  Mol Cell       Date:  2015-09-03       Impact factor: 17.970

Review 9.  Mechanisms and function of substrate recruitment by F-box proteins.

Authors:  Jeffrey R Skaar; Julia K Pagan; Michele Pagano
Journal:  Nat Rev Mol Cell Biol       Date:  2013-05-09       Impact factor: 94.444

10.  Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.

Authors:  Min Zhuang; Matthew F Calabrese; Jiang Liu; M Brett Waddell; Amanda Nourse; Michal Hammel; Darcie J Miller; Helen Walden; David M Duda; Steven N Seyedin; Timothy Hoggard; J Wade Harper; Kevin P White; Brenda A Schulman
Journal:  Mol Cell       Date:  2009-10-09       Impact factor: 17.970
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  7 in total

Review 1.  Race and prostate cancer: genomic landscape.

Authors:  Camilo Arenas-Gallo; Jude Owiredu; Ilon Weinstein; Patrick Lewicki; Spyridon P Basourakos; Randy Vince; Bashir Al Hussein Al Awamlh; Fredrick R Schumacher; Daniel E Spratt; Christopher E Barbieri; Jonathan E Shoag
Journal:  Nat Rev Urol       Date:  2022-08-09       Impact factor: 16.430

2.  GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer.

Authors:  Marieke Burleson; Janice J Deng; Tai Qin; Thu Minh Duong; Yuqian Yan; Xiang Gu; Debodipta Das; Acarizia Easley; Michael A Liss; P Renee Yew; Roble Bedolla; Addanki Pratap Kumar; Tim Hui-Ming Huang; Yi Zou; Yidong Chen; Chun-Liang Chen; Haojie Huang; Lu-Zhe Sun; Thomas G Boyer
Journal:  Mol Cancer Res       Date:  2021-10-05       Impact factor: 6.333

Review 3.  The ubiquitin ligase adaptor SPOP in cancer.

Authors:  Matthew J Cuneo; Tanja Mittag
Journal:  FEBS J       Date:  2019-09-18       Impact factor: 5.542

4.  SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG.

Authors:  Jonathan Shoag; Deli Liu; Mirjam Blattner; Andrea Sboner; Kyung Park; Lesa Deonarine; Brian D Robinson; Juan Miguel Mosquera; Yu Chen; Mark A Rubin; Christopher E Barbieri
Journal:  J Clin Invest       Date:  2017-12-04       Impact factor: 14.808

5.  LncRNA ADAMTS9-AS2 suppresses the proliferation of gastric cancer cells and the tumorigenicity of cancer stem cells through regulating SPOP.

Authors:  Feiran Wang; Chong Tang; Dong Xu; Yijie Tang; Yasu Jiang; Xuesong Gao; Junfei Xu
Journal:  J Cell Mol Med       Date:  2020-03-11       Impact factor: 5.310

Review 6.  The diverse roles of SPOP in prostate cancer and kidney cancer.

Authors:  Zhiwei Wang; Yizuo Song; Miaomiao Ye; Xiaoming Dai; Xueqiong Zhu; Wenyi Wei
Journal:  Nat Rev Urol       Date:  2020-04-30       Impact factor: 14.432

Review 7.  Functional roles of Speckle-Type Poz (SPOP) Protein in Genomic stability.

Authors:  Xi Wei; Joshua Fried; Ying Li; Linfei Hu; Ming Gao; Sheng Zhang; Bo Xu
Journal:  J Cancer       Date:  2018-09-07       Impact factor: 4.207
  7 in total

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