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Literature DB >> 15688063

Function and regulation of cullin-RING ubiquitin ligases.

Matthew D Petroski¹, Raymond J Deshaies.

Abstract

Cullin-RING complexes comprise the largest known class of ubiquitin ligases. Owing to the great diversity of their substrate-receptor subunits, it is possible that there are hundreds of distinct cullin-RING ubiquitin ligases in eukaryotic cells, which establishes these enzymes as key mediators of post-translational protein regulation. In this review, we focus on the composition, regulation and function of cullin-RING ligases, and describe how these enzymes can be characterized by a set of general principles.

Entities: Gene

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Year: 2005 PMID： 15688063 DOI： 10.1038/nrm1547

Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444

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Cited

1015 in total

1. Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress.

Authors: Flore Kruiswijk; Laurensia Yuniati; Roberto Magliozzi; Teck Yew Low; Ratna Lim; Renske Bolder; Shabaz Mohammed; Christopher G Proud; Albert J R Heck; Michele Pagano; Daniele Guardavaccaro
Journal: Sci Signal Date: 2012-06-05 Impact factor: 8.192

2. The cullin-4 complex DCDC does not require E3 ubiquitin ligase elements to control heterochromatin in Neurospora crassa.

Authors: Keyur K Adhvaryu; Jordan D Gessaman; Shinji Honda; Zachary A Lewis; Paula L Grisafi; Eric U Selker
Journal: Eukaryot Cell Date: 2014-10-31

3. GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α.

Authors: Daniela Flügel; Agnes Görlach; Thomas Kietzmann
Journal: Blood Date: 2011-12-05 Impact factor: 22.113

4. Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation.

Authors: Anjali Teckchandani; George S Laszlo; Sergi Simó; Khyati Shah; Carissa Pilling; Alexander A Strait; Jonathan A Cooper
Journal: J Cell Sci Date: 2013-11-27 Impact factor: 5.285

5. The Arabidopsis F-box protein CORONATINE INSENSITIVE1 is stabilized by SCFCOI1 and degraded via the 26S proteasome pathway.

Authors: Jianbin Yan; Haiou Li; Shuhua Li; Ruifeng Yao; Haiteng Deng; Qi Xie; Daoxin Xie
Journal: Plant Cell Date: 2013-02-05 Impact factor: 11.277

6. Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase.

Authors: Andrew M Hudson; Katelynn M Mannix; Lynn Cooley
Journal: Genetics Date: 2015-09-16 Impact factor: 4.562

Function and regulation of cullin-RING ubiquitin ligases.

1. Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress.

2. The cullin-4 complex DCDC does not require E3 ubiquitin ligase elements to control heterochromatin in Neurospora crassa.

3. GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α.

4. Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation.

5. The Arabidopsis F-box protein CORONATINE INSENSITIVE1 is stabilized by SCFCOI1 and degraded via the 26S proteasome pathway.

6. Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase.

Review 7. Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases.

Review 8. Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1.

9. KLHL6 is a tumor suppressor gene in diffuse large B-cell lymphoma.

Review 10. Structural and functional insights to ubiquitin-like protein conjugation.