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Literature DB >> 25058385

The emerging role of speckle-type POZ protein (SPOP) in cancer development.

Abstract

Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is an E3 ubiquitin ligase adaptor protein that is frequently mutated in prostate and endometrial cancers. All the cancer-associated SPOP mutations reported to date are clustered in the meprin and TRAF (Tumor necrosis factor receptor-associated factor) homology (MATH) domain, presumably affecting substrate binding. SPOP mutations in prostate cancer are mutually exclusive with the ETS (Erythroblast transformation-specific) family gene rearrangements and define a distinct molecular subclass of prostate cancer. SPOP mutations contribute to prostate cancer development by altering the steady-state levels of key components in the androgen-signaling pathway.

Entities: CellLine Chemical Disease Gene Mutation Species

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Year: 2014 PMID： 25058385 PMCID： PMC4237012 DOI： 10.1016/j.drudis.2014.07.009

Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851

43 in total

1. Basic Medical Research Award. The ubiquitin system.

Authors: A Hershko; A Ciechanover; A Varshavsky
Journal: Nat Med Date: 2000-10 Impact factor: 53.440

2. Gene amplification and expression of the steroid receptor coactivator SRC3 (AIB1) in sporadic breast and endometrial carcinomas.

Authors: M Glaeser; T Floetotto; B Hanstein; M W Beckmann; D Niederacher
Journal: Horm Metab Res Date: 2001-03 Impact factor: 2.936

3. A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains.

Authors: J M Zapata; K Pawlowski; E Haas; C F Ware; A Godzik; J C Reed
Journal: J Biol Chem Date: 2001-02-21 Impact factor: 5.157

4. Speckle-type POZ protein, SPOP, is involved in the DNA damage response.

Authors: Dan Zhang; Haibo Wang; Mianen Sun; Jun Yang; Wei Zhang; Suxia Han; Bo Xu
Journal: Carcinogenesis Date: 2014-01-22 Impact factor: 4.944

5. SPOP mutations in prostate cancer across demographically diverse patient cohorts.

Authors: Mirjam Blattner; Daniel J Lee; Catherine O'Reilly; Kyung Park; Theresa Y MacDonald; Francesca Khani; Kevin R Turner; Ya-Lin Chiu; Peter J Wild; Igor Dolgalev; Adriana Heguy; Andrea Sboner; Sinan Ramazangolu; Haley Hieronymus; Charles Sawyers; Ashutosh K Tewari; Holger Moch; Ghil Suk Yoon; Yong Chul Known; Ove Andrén; Katja Fall; Francecsa Demichelis; Juan Miguel Mosquera; Brian D Robinson; Christopher E Barbieri; Mark A Rubin
Journal: Neoplasia Date: 2014-01 Impact factor: 5.715

6. EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes.

Authors: R Li; H Pei; D K Watson; T S Papas
Journal: Oncogene Date: 2000-02-10 Impact factor: 9.867

7. SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.

Authors: Guoqiang Li; Weimin Ci; Subhradip Karmakar; Ke Chen; Ruby Dhar; Zhixiang Fan; Zhongqiang Guo; Jing Zhang; Yuwen Ke; Lu Wang; Min Zhuang; Shengdi Hu; Xuesong Li; Liqun Zhou; Xianghong Li; Matthew F Calabrese; Edmond R Watson; Sandip M Prasad; Carrie Rinker-Schaeffer; Scott E Eggener; Thomas Stricker; Yong Tian; Brenda A Schulman; Jiang Liu; Kevin P White
Journal: Cancer Cell Date: 2014-03-20 Impact factor: 31.743

8. The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.

Authors: Lionel Pintard; John H Willis; Andrew Willems; Jacque-Lynne F Johnson; Martin Srayko; Thimo Kurz; Sarah Glaser; Paul E Mains; Mike Tyers; Bruce Bowerman; Matthias Peter
Journal: Nature Date: 2003-09-03 Impact factor: 49.962

9. MacroH2A1.2 binds the nuclear protein Spop.

Authors: Ichiro Takahashi; Yosuke Kameoka; Katsuyuki Hashimoto
Journal: Biochim Biophys Acta Date: 2002-08-19

10. Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutants.

Authors: Jian An; Chenji Wang; Yibin Deng; Long Yu; Haojie Huang
Journal: Cell Rep Date: 2014-02-06 Impact factor: 9.423

35 in total

1. Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.

Authors: Linli Zhang; Shan Peng; Xiangpeng Dai; Wenjian Gan; Xin Nie; Wenyi Wei; Guoqing Hu; Jianping Guo
Journal: Cancer Lett Date: 2017-01-13 Impact factor: 8.679

2. Somatic genetic alterations in synchronous and metachronous low-grade serous tumours and high-grade carcinomas of the adnexa.

Authors: Rajmohan Murali; Pier Selenica; David N Brown; R Keira Cheetham; Raghu Chandramohan; Nidia L Claros; Nancy Bouvier; Donavan T Cheng; Robert A Soslow; Britta Weigelt; W Glenn McCluggage
Journal: Histopathology Date: 2019-01-15 Impact factor: 5.087

3. Speckle-type POZ (pox virus and zinc finger protein) protein gene deletion in ovarian cancer: Fluorescence in situ hybridization analysis of a tissue microarray.

Authors: Xiaoyu Hu; Zhu Yang; Manman Zeng; Y I Liu; Xiaotao Yang; Yanan Li; X U Li; Qiubo Yu
Journal: Oncol Lett Date: 2016-05-30 Impact factor: 2.967

The emerging role of speckle-type POZ protein (SPOP) in cancer development.

1. Basic Medical Research Award. The ubiquitin system.

2. Gene amplification and expression of the steroid receptor coactivator SRC3 (AIB1) in sporadic breast and endometrial carcinomas.

3. A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains.

4. Speckle-type POZ protein, SPOP, is involved in the DNA damage response.

5. SPOP mutations in prostate cancer across demographically diverse patient cohorts.

6. EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes.

7. SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.

8. The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.

9. MacroH2A1.2 binds the nuclear protein Spop.

10. Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutants.

1. Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.

2. Somatic genetic alterations in synchronous and metachronous low-grade serous tumours and high-grade carcinomas of the adnexa.

3. Speckle-type POZ (pox virus and zinc finger protein) protein gene deletion in ovarian cancer: Fluorescence in situ hybridization analysis of a tissue microarray.

Review 4. Protein phase separation: A novel therapy for cancer?

Review 5. Functional analysis of Cullin 3 E3 ligases in tumorigenesis.

6. SPOP tips the balance of BETs in cancer.

7. Expression and clinical relevance of SPOPL in medulloblastoma.

8. Cu(I) Disrupts the Structure and Function of the Nonclassical Zinc Finger Protein Tristetraprolin (TTP).

9. Uterine function in the mouse requires speckle-type poz protein.

10. SPOP-mediated degradation of BRD4 dictates cellular sensitivity to BET inhibitors.