Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Constitutional epimutation as a mechanism for cancer causality and heritability?

Literature DB >> 26383139

Constitutional epimutation as a mechanism for cancer causality and heritability?

Abstract

Constitutional epimutation, which is an aberration in gene expression due to an altered epigenotype that is widely distributed in normal tissues (albeit frequently mosaic), provides an alternative mechanism to genetic mutation for cancer predisposition. Observational studies in cancer-affected families have revealed intergenerational inheritance of constitutional epimutation, providing unique insights into the heritability of epigenetic traits in humans. In this Opinion article, the potential contribution of constitutional epimutation to the 'missing' causality and heritability of cancer is explored.

Entities: Disease Species

Mesh：

Year: 2015 PMID： 26383139 DOI： 10.1038/nrc4001

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

117 in total

1. Chromosomal instability and tumors promoted by DNA hypomethylation.

Authors: Amir Eden; François Gaudet; Alpana Waghmare; Rudolf Jaenisch
Journal: Science Date: 2003-04-18 Impact factor: 47.728

2. Personal genomes: The case of the missing heritability.

Authors: Brendan Maher
Journal: Nature Date: 2008-11-06 Impact factor: 49.962

3. Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma.

Authors: Bomsoo Cho; Hansoo Lee; ShinWu Jeong; Yung-Jue Bang; Hyun Joo Lee; Kyu Sang Hwang; Hae-Yeong Kim; Yun-Sil Lee; Gyeong Hoon Kang; Doo-Il Jeoung
Journal: Biochem Biophys Res Commun Date: 2003-07-18 Impact factor: 3.575

4. Germline epimutations of APC are not associated with inherited colorectal polyposis.

Authors: M Hitchins; C Suter; J Wong; K Cheong; N Hawkins; B Leggett; R Scott; A Spigelman; I Tomlinson; D Martin; R Ward
Journal: Gut Date: 2006-04 Impact factor: 23.059

5. Dynamic CpG island methylation landscape in oocytes and preimplantation embryos.

Authors: Sébastien A Smallwood; Shin-Ichi Tomizawa; Felix Krueger; Nico Ruf; Natasha Carli; Anne Segonds-Pichon; Shun Sato; Kenichiro Hata; Simon R Andrews; Gavin Kelsey
Journal: Nat Genet Date: 2011-06-26 Impact factor: 38.330

6. Increased methylation variation in epigenetic domains across cancer types.

Authors: Kasper Daniel Hansen; Winston Timp; Héctor Corrada Bravo; Sarven Sabunciyan; Benjamin Langmead; Oliver G McDonald; Bo Wen; Hao Wu; Yun Liu; Dinh Diep; Eirikur Briem; Kun Zhang; Rafael A Irizarry; Andrew P Feinberg
Journal: Nat Genet Date: 2011-06-26 Impact factor: 38.330

7. Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer.

Authors: Adele Murrell; Yoko Ito; Gaetano Verde; Joanna Huddleston; Kathryn Woodfine; Margherita Cirillo Silengo; Filippo Spreafico; Daniela Perotti; Agostina De Crescenzo; Angela Sparago; Flavia Cerrato; Andrea Riccio
Journal: PLoS One Date: 2008-03-26 Impact factor: 3.240

8. Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming.

Authors: Khursheed Iqbal; Diana A Tran; Arthur X Li; Charles Warden; Angela Y Bai; Purnima Singh; Xiwei Wu; Gerd P Pfeifer; Piroska E Szabó
Journal: Genome Biol Date: 2015-03-27 Impact factor: 13.583

9. Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer.

Authors: Tamara Hansmann; Galyna Pliushch; Monika Leubner; Patricia Kroll; Daniela Endt; Andrea Gehrig; Sabine Preisler-Adams; Peter Wieacker; Thomas Haaf
Journal: Hum Mol Genet Date: 2012-07-27 Impact factor: 6.150

Review 10. Endocrine disrupters: the new players able to affect the epigenome.

Authors: Lavinia Casati; Ramon Sendra; Valeria Sibilia; Fabio Celotti
Journal: Front Cell Dev Biol Date: 2015-06-18

31 in total

1. High-Resolution Bisulfite-Sequencing of Peripheral Blood DNA Methylation in Early-Onset and Familial Risk Breast Cancer Patients.

Authors: Justin Chen; Maria K Haanpää; Joshua J Gruber; Natalie Jäger; James M Ford; Michael P Snyder
Journal: Clin Cancer Res Date: 2019-06-07 Impact factor: 12.531

Review 2. Epigenetics and Precision Oncology.

Authors: Rachael J Werner; Andrew D Kelly; Jean-Pierre J Issa
Journal: Cancer J Date: 2017 Sep/Oct Impact factor: 3.360

3. Constitutional BRCA1 Methylation and Risk of Incident Triple-Negative Breast Cancer and High-grade Serous Ovarian Cancer.

Authors: Per E Lønning; Oleksii Nikolaienko; Kathy Pan; Allison W Kurian; Hans P Eikesdal; Mary Pettinger; Garnet L Anderson; Ross L Prentice; Rowan T Chlebowski; Stian Knappskog
Journal: JAMA Oncol Date: 2022-09-08 Impact factor: 33.006

Review 4. Pancreatic cancer biology and genetics from an evolutionary perspective.

Authors: Alvin Makohon-Moore; Christine A Iacobuzio-Donahue
Journal: Nat Rev Cancer Date: 2016-07-22 Impact factor: 60.716

5. Childhood cancer in children with congenital anomalies in Oklahoma, 1997 to 2009.

Authors: Amanda E Janitz; Barbara R Neas; Janis E Campbell; Anne E Pate; Julie A Stoner; Sheryl L Magzamen; Jennifer D Peck
Journal: Birth Defects Res A Clin Mol Teratol Date: 2016-03-04

Review 6. Mosaicism in Patients With Colorectal Cancer or Polyposis Syndromes: A Systematic Review.

Authors: Anne Maria Lucia Jansen; Ajay Goel
Journal: Clin Gastroenterol Hepatol Date: 2020-03-05 Impact factor: 11.382

7. The landscape of early carcinogenesis revealed through the lens of integrative genomics, epigenomics, and transcriptomics.

Authors: Aysegul Balyimez; Kevin L Stephans; Mohamed E Abazeed; Omar Y Mian
Journal: J Thorac Dis Date: 2019-06 Impact factor: 3.005

8. Defining the criteria for identifying constitutional epimutations.

Authors: Mathew A Sloane; Robyn L Ward; Luke B Hesson
Journal: Clin Epigenetics Date: 2016-04-18 Impact factor: 6.551

9. Classification of Colon Cancer Patients Based on the Methylation Patterns of Promoters.

Authors: Wonyoung Choi; Jungwoo Lee; Jin-Young Lee; Sun-Min Lee; Da-Won Kim; Young-Joon Kim
Journal: Genomics Inform Date: 2016-06-30

10. PRDX1 gene-related epi-cblC disease is a common type of inborn error of cobalamin metabolism with mono- or bi-allelic MMACHC epimutations.

Authors: Catia Cavicchi; Abderrahim Oussalah; Silvia Falliano; Lorenzo Ferri; Alessia Gozzini; Serena Gasperini; Serena Motta; Miriam Rigoldi; Giancarlo Parenti; Albina Tummolo; Concetta Meli; Francesca Menni; Francesca Furlan; Marta Daniotti; Sabrina Malvagia; Giancarlo la Marca; Céline Chery; Pierre-Emmanuel Morange; David Tregouet; Maria Alice Donati; Renzo Guerrini; Jean-Louis Guéant; Amelia Morrone
Journal: Clin Epigenetics Date: 2021-07-02 Impact factor: 6.551