| Literature DB >> 26377894 |
Andrew J Macpherson1, Kathy D McCoy2.
Abstract
IgA is induced through T-cell-dependent and -independent pathways. In this issue, Bunker et al. (2015) now show that the T-cell-independent pathway is sufficient to coat most small intestinal microbes specifically, and Fransen et al. (2015) find that IgA coating promotes uptake of microbes into Peyer's patches and drives further induction in a positive-feedback loop.Mesh:
Substances:
Year: 2015 PMID: 26377894 DOI: 10.1016/j.immuni.2015.08.024
Source DB: PubMed Journal: Immunity ISSN: 1074-7613 Impact factor: 31.745