| Literature DB >> 26376830 |
K Aljumah1, M A Hassali2.
Abstract
BACKGROUND: Adherence to antidepressant treatment is essential for the effective management of patients with major depressive disorder. Adherence to medication is a dynamic decision-making process, and pharmacists play an important role in improving adherence to antidepressant treatment in different settings within the healthcare system. The aim of this study was to assess whether pharmacist interventions based on shared decision making improved adherence and patient-related outcomes.Entities:
Mesh:
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Year: 2015 PMID: 26376830 PMCID: PMC4574071 DOI: 10.1186/s12888-015-0605-8
Source DB: PubMed Journal: BMC Psychiatry ISSN: 1471-244X Impact factor: 3.630
Fig. 1Recruitment flow diagram
Demographic characteristics of intervention group (n = 110) and control group (n = 110) patients
| Intervention group | Control group | |
|---|---|---|
| No (%) | No (%) | |
|
| ||
| Male | 49 (44.5) | 51 (46.4) |
| Female | 61 (55.5) | 59 (53.6) |
|
| ||
| 18–30 years | 32 (29.1) | 27 (24.5) |
| 31–40 years | 31 (28.2) | 35 (31.8) |
| 41–50 years | 27 (24.5) | 27 (24.5) |
| 51–60 years | 20 (18.2) | 21 (19.1) |
|
| ||
| Uneducated | 19 (17.3) | 31 (28.2) |
| Primary | 17 (15.5) | 17 (15.5) |
| Intermediate | 21 (19.1) | 23 (20.9) |
| Secondary | 37 (33.6) | 29 (26.4) |
| College/Bachelor | 16 (14.5) | 10 (9.1) |
|
| ||
| One | 86 (78.2) | 95 (86.4) |
| Two | 24 (21.8) | 15 (13.6) |
Clinical characteristics and outcomes in intervention group and control group patients
| Intervention group | Control group | T-value | Sig. | |
|---|---|---|---|---|
| Mean (S.D.) | Mean (S.D.) | |||
| General overuse | 12.42 (2.24) | 12.74 (2.63) | 0.966 | 0.335 |
| General harm | 11.16 (2.50) | 10.88 (2.96) | 0.763 | 0.446 |
| Beneficial effect of pharmaceuticals | 14.69 (1.97) | 14.96 (2.14) | 0.984 | 0.326 |
| Beliefs about medicines | 38.27 (3.92) | 38.58 (4.48) | 0.545 | 0.587 |
| Sensitive | 15.72 (2.66) | 15.55 (3.13) | 0.441 | 0.660 |
| Necessity beliefs | 18.19 (3.68) | 18.30 (4.19) | 0.205 | 0.838 |
| Concern beliefs | 13.07 (3.36) | 13.38 (4.04) | 0.616 | 0.538 |
| Treatment Satisfaction Questionnaire for Medication (TSQM) | 83.20 (11.42) | 82.54 (13.41) | 0.396 | 0.692 |
| Estimated weights for EQ-5D | 0.63 (0.37) | 0.65 (0.38) | 0.414 | 0.680 |
| Montgomery–Åsberg Depression Scale | 22.90 (13.27) | 21.44 (12.89) | 0.830 | 0.408 |
| Medication Adherence Scale | 5.13 (1.80) | 5.19 (2.05) | 0.218 | 0.827 |
T-test for the difference in the characteristics of the study, according to the level of adherence
Clinical characteristics and outcomes in intervention group and control group patients after 3 months
| Intervention group | Control group | T-value | Sig. | |
|---|---|---|---|---|
| Mean (S.D.) | Mean (S.D.) | |||
| General overuse | 12.17 (2.19) | 12.69 (2.62) | 1.583 | 0.115 |
| General harm | 10.61 (2.37) | 10.77 (2.93) | 0.467 | 0.641 |
| Beneficial effect of pharmaceuticals | 14.91 (1.99) | 15.11 (2.15) | 0.708 | 0.480 |
| Beliefs about medicines | 36.84 (3.77) | 38.43 (4.46) | 2.855 | 0.005a |
| Sensitive | 15.40 (2.61) | 15.47 (3.11) | 0.165 | 0.869 |
| Necessity beliefs | 18.73 (3.78) | 18.46 (4.19) | 0.509 | 0.611 |
| Concern beliefs | 12.42 (3.18) | 13.25 (4.00) | 1.694 | 0.092 |
| Treatment Satisfaction Questionnaire for Medication (TSQM) | 86.68 (11.08) | 82.82 (13.40) | 2.326 | 0.021a |
| Estimated weights for EQ-5D | 0.66 (0.39) | 0.65 (0.38) | 0.076 | 0.939 |
| Montgomery–Åsberg Depression Scale | 21.07 (12.21) | 21.01 (12.63) | 0.036 | 0.971 |
| Medication Adherence Scale | 5.79 (1.89) | 5.04 (1.98) | 2.880 | 0.004a |
aSignificantly different
Clinical characteristics and outcomes in intervention group and control group patients after 6 months
| Intervention group | Control group | T-value | Sig. | |
|---|---|---|---|---|
| Mean (S.D.) | Mean (S.D.) | |||
| General overuse | 11.93 (2.15) | 12.63 (2.61) | 2.197 | 0.029a |
| General harm | 10.08 (2.25) | 10.67 (2.90) | 1.687 | 0.093 |
| Beneficial effect of pharmaceuticals | 15.35 (2.04) | 15.25 (2.15) | 0.356 | 0.722 |
| Beliefs about medicines | 35.36 (3.62) | 38.12 (4.43) | 5.055 | <0.0001a |
| Sensitive | 15.10 (2.56) | 15.39 (3.10) | 0.769 | 0.442 |
| Necessity beliefs | 19.00 (3.83) | 18.50 (4.19) | 0.939 | 0.349 |
| Concern beliefs | 12.05 (3.08) | 13.14 (3.97) | 2.278 | 0.024 |
| Treatment Satisfaction Questionnaire for Medication (TSQM) | 88.71 (10.77) | 82.89 (13.40) | 3.551 | <0.0001a |
| Estimated weights for EQ-5D | 0.68 (0.40) | 0.66 (0.38) | 0.356 | 0.722 |
| Montgomery–Åsberg Depression Scale | 20.65 (11.97) | 20.86 (12.54) | 0.129 | 0.897 |
| Medication Adherence Scale | 5.99 (1.88) | 4.94 (1.94) | 4.059 | <0.0001a |
aSignificantly different