| Literature DB >> 26366552 |
Matthew R Robinson1, Gibran Hemani1, Carolina Medina-Gomez2, Massimo Mezzavilla3,4, Tonu Esko5,6,7,8, Konstantin Shakhbazov1, Joseph E Powell1,9, Anna Vinkhuyzen1, Sonja I Berndt10, Stefan Gustafsson11, Anne E Justice12, Bratati Kahali13,14, Adam E Locke15, Tune H Pers6,7,8,16, Sailaja Vedantam6,7, Andrew R Wood17, Wouter van Rheenen18, Ole A Andreassen19, Paolo Gasparini3,4, Andres Metspalu5, Leonard H van den Berg18, Jan H Veldink18, Fernando Rivadeneira2, Thomas M Werge20,21,22, Goncalo R Abecasis15, Dorret I Boomsma23,24,25, Daniel I Chasman8,26, Eco J C de Geus23,24,25, Timothy M Frayling17, Joel N Hirschhorn5,6,7,8, Jouke Jan Hottenga23,24,25, Erik Ingelsson11,27, Ruth J F Loos28,29,30,31, Patrik K E Magnusson32, Nicholas G Martin33, Grant W Montgomery33, Kari E North13,14,34, Nancy L Pedersen32, Timothy D Spector35, Elizabeth K Speliotes15, Michael E Goddard36,37, Jian Yang1,9, Peter M Visscher1,9.
Abstract
Across-nation differences in the mean values for complex traits are common, but the reasons for these differences are unknown. Here we find that many independent loci contribute to population genetic differences in height and body mass index (BMI) in 9,416 individuals across 14 European countries. Using discovery data on over 250,000 individuals and unbiased effect size estimates from 17,500 sibling pairs, we estimate that 24% (95% credible interval (CI) = 9%, 41%) and 8% (95% CI = 4%, 16%) of the captured additive genetic variance for height and BMI, respectively, reflect population genetic differences. Population genetic divergence differed significantly from that in a null model (height, P < 3.94 × 10(-8); BMI, P < 5.95 × 10(-4)), and we find an among-population genetic correlation for tall and slender individuals (r = -0.80, 95% CI = -0.95, -0.60), consistent with correlated selection for both phenotypes. Observed differences in height among populations reflected the predicted genetic means (r = 0.51; P < 0.001), but environmental differences across Europe masked genetic differentiation for BMI (P < 0.58).Entities:
Mesh：
Year: 2015 PMID： 26366552 PMCID： PMC4984852 DOI： 10.1038/ng.3401
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330