Literature DB >> 26364162

Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk.

Eunjung Lee1, Daniel O Stram2, Weronica E Ek3, Lynn E Onstad4, Stuart MacGregor3, Puya Gharahkhani3, Weimin Ye5, Jesper Lagergren6, Nicholas J Shaheen7, Liam J Murray8, Laura J Hardie9, Marilie D Gammon10, Wong-Ho Chow11, Harvey A Risch12, Douglas A Corley13, David M Levine14, David C Whiteman15, Leslie Bernstein16, Nigel C Bird17, Thomas L Vaughan4, Anna H Wu2.   

Abstract

BACKGROUND: Several cancer-associated loci identified from genome-wide association studies (GWAS) have been associated with risks of multiple cancer sites, suggesting pleiotropic effects. We investigated whether GWAS-identified risk variants for other common cancers are associated with risk of esophageal adenocarcinoma (EA) or its precursor, Barrett's esophagus.
METHODS: We examined the associations between risks of EA and Barrett's esophagus and 387 SNPs that have been associated with risks of other cancers, by using genotype imputation data on 2,163 control participants and 3,885 (1,501 EA and 2,384 Barrett's esophagus) case patients from the Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study, and investigated effect modification by smoking history, body mass index (BMI), and reflux/heartburn.
RESULTS: After correcting for multiple testing, none of the tested 387 SNPs were statistically significantly associated with risk of EA or Barrett's esophagus. No evidence of effect modification by smoking, BMI, or reflux/heartburn was observed.
CONCLUSIONS: Genetic risk variants for common cancers identified from GWAS appear not to be associated with risks of EA or Barrett's esophagus. IMPACT: To our knowledge, this is the first investigation of pleiotropic genetic associations with risks of EA and Barrett's esophagus. ©2015 American Association for Cancer Research.

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Year:  2015        PMID: 26364162      PMCID: PMC4648999          DOI: 10.1158/1055-9965.EPI-15-0596

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN: 1055-9965            Impact factor:   4.254


  8 in total

1.  So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests.

Authors:  Karen N Conneely; Michael Boehnke
Journal:  Am J Hum Genet       Date:  2007-12       Impact factor: 11.025

2.  A genome-wide pleiotropy scan for prostate cancer risk.

Authors:  Orestis A Panagiotou; Ruth C Travis; Daniele Campa; Sonja I Berndt; Sara Lindstrom; Peter Kraft; Fredrick R Schumacher; Afshan Siddiq; Stefania I Papatheodorou; Janet L Stanford; Demetrius Albanes; Jarmo Virtamo; Stephanie J Weinstein; W Ryan Diver; Susan M Gapstur; Victoria L Stevens; Heiner Boeing; H Bas Bueno-de-Mesquita; Aurelio Barricarte Gurrea; Rudolf Kaaks; Kay-Tee Khaw; Vittorio Krogh; Kim Overvad; Elio Riboli; Dimitrios Trichopoulos; Edward Giovannucci; Meir Stampfer; Christopher Haiman; Brian Henderson; Loic Le Marchand; J Michael Gaziano; David J Hunter; Stella Koutros; Meredith Yeager; Robert N Hoover; Stephen J Chanock; Sholom Wacholder; Timothy J Key; Konstantinos K Tsilidis
Journal:  Eur Urol       Date:  2014-09-30       Impact factor: 20.096

3.  Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.

Authors:  Claire Palles; Laura Chegwidden; Xinzhong Li; John M Findlay; Garry Farnham; Francesc Castro Giner; Maikel P Peppelenbosch; Michal Kovac; Claire L Adams; Hans Prenen; Sarah Briggs; Rebecca Harrison; Scott Sanders; David MacDonald; Chris Haigh; Art Tucker; Sharon Love; Manoj Nanji; John deCaestecker; David Ferry; Barrie Rathbone; Julie Hapeshi; Hugh Barr; Paul Moayyedi; Peter Watson; Barbara Zietek; Neera Maroo; Laura Gay; Tim Underwood; Lisa Boulter; Hugh McMurtry; David Monk; Praful Patel; Krish Ragunath; David Al Dulaimi; Iain Murray; Konrad Koss; Andrew Veitch; Nigel Trudgill; Chuka Nwokolo; Bjorn Rembacken; Paul Atherfold; Elaine Green; Yeng Ang; Ernst J Kuipers; Wu Chow; Stuart Paterson; Sudarshan Kadri; Ian Beales; Charles Grimley; Paul Mullins; Conrad Beckett; Mark Farrant; Andrew Dixon; Sean Kelly; Matthew Johnson; Shahjehan Wajed; Anjan Dhar; Elinor Sawyer; Rebecca Roylance; Lynn Onstad; Marilie D Gammon; Douglas A Corley; Nicholas J Shaheen; Nigel C Bird; Laura J Hardie; Brian J Reid; Weimin Ye; Geoffrey Liu; Yvonne Romero; Leslie Bernstein; Anna H Wu; Alan G Casson; Rebecca Fitzgerald; David C Whiteman; Harvey A Risch; David M Levine; Tom L Vaughan; Auke P Verhaar; Jan van den Brande; Eelke L Toxopeus; Manon C Spaander; Bas P L Wijnhoven; Luc J W van der Laan; Kausilia Krishnadath; Cisca Wijmenga; Gosia Trynka; Ross McManus; John V Reynolds; Jacintha O'Sullivan; Padraic MacMathuna; Sarah A McGarrigle; Dermot Kelleher; Severine Vermeire; Isabelle Cleynen; Raf Bisschops; Ian Tomlinson; Janusz Jankowski
Journal:  Gastroenterology       Date:  2014-11-05       Impact factor: 22.682

4.  A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.

Authors:  David M Levine; Weronica E Ek; Rui Zhang; Xinxue Liu; Lynn Onstad; Cassandra Sather; Pierre Lao-Sirieix; Marilie D Gammon; Douglas A Corley; Nicholas J Shaheen; Nigel C Bird; Laura J Hardie; Liam J Murray; Brian J Reid; Wong-Ho Chow; Harvey A Risch; Olof Nyrén; Weimin Ye; Geoffrey Liu; Yvonne Romero; Leslie Bernstein; Anna H Wu; Alan G Casson; Stephen J Chanock; Patricia Harrington; Isabel Caldas; Irene Debiram-Beecham; Carlos Caldas; Nicholas K Hayward; Paul D Pharoah; Rebecca C Fitzgerald; Stuart Macgregor; David C Whiteman; Thomas L Vaughan
Journal:  Nat Genet       Date:  2013-10-13       Impact factor: 38.330

5.  Germline genetic contributions to risk for esophageal adenocarcinoma, Barrett's esophagus, and gastroesophageal reflux.

Authors:  Weronica E Ek; David M Levine; Mauro D'Amato; Nancy L Pedersen; Patrik K E Magnusson; Francesca Bresso; Lynn E Onstad; Peter T Schmidt; Hans Törnblom; Helena Nordenstedt; Yvonne Romero; Wong-Ho Chow; Liam J Murray; Marilie D Gammon; Geoffrey Liu; Leslie Bernstein; Alan G Casson; Harvey A Risch; Nicholas J Shaheen; Nigel C Bird; Brian J Reid; Douglas A Corley; Laura J Hardie; Weimin Ye; Anna H Wu; Marco Zucchelli; Tim D Spector; Pirro Hysi; Thomas L Vaughan; David C Whiteman; Stuart MacGregor
Journal:  J Natl Cancer Inst       Date:  2013-10-29       Impact factor: 13.506

6.  Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia.

Authors:  Veronica Wendy Setiawan; Fredrick Schumacher; Jennifer Prescott; Jeffrey Haessler; Jennifer Malinowski; Nicolas Wentzensen; Hannah Yang; Stephen Chanock; Louise Brinton; Patricia Hartge; Jolanta Lissowska; S Lani Park; Iona Cheng; William S Bush; Dana C Crawford; Giske Ursin; Pamela Horn-Ross; Leslie Bernstein; Lingeng Lu; Harvey Risch; Herbert Yu; Lori C Sakoda; Jennifer Doherty; Chu Chen; Rebecca Jackson; Shagufta Yasmeen; Michele Cote; Jonathan M Kocarnik; Ulrike Peters; Peter Kraft; Immaculata De Vivo; Christopher A Haiman; Charles Kooperberg; Loic Le Marchand
Journal:  Carcinogenesis       Date:  2014-05-15       Impact factor: 4.741

7.  A genome-wide "pleiotropy scan" does not identify new susceptibility loci for estrogen receptor negative breast cancer.

Authors:  Daniele Campa; Myrto Barrdahl; Konstantinos K Tsilidis; Gianluca Severi; W Ryan Diver; Afshan Siddiq; Stephen Chanock; Robert N Hoover; Regina G Ziegler; Christine D Berg; Saundra S Buys; Christopher A Haiman; Brian E Henderson; Fredrick R Schumacher; Loïc Le Marchand; Dieter Flesch-Janys; Sara Lindström; David J Hunter; Susan E Hankinson; Walter C Willett; Peter Kraft; David G Cox; Kay-Tee Khaw; Anne Tjønneland; Laure Dossus; Dimitrios Trichopoulos; Salvatore Panico; Carla H van Gils; Elisabete Weiderpass; Aurelio Barricarte; Malin Sund; Mia M Gaudet; Graham Giles; Melissa Southey; Laura Baglietto; Jenny Chang-Claude; Rudolf Kaaks; Federico Canzian
Journal:  PLoS One       Date:  2014-02-11       Impact factor: 3.240

8.  Pleiotropy of cancer susceptibility variants on the risk of non-Hodgkin lymphoma: the PAGE consortium.

Authors:  Unhee Lim; Jonathan M Kocarnik; William S Bush; Tara C Matise; Christian Caberto; Sungshim Lani Park; Christopher S Carlson; Ewa Deelman; David Duggan; Megan Fesinmeyer; Christopher A Haiman; Brian E Henderson; Lucia A Hindorff; Laurence N Kolonel; Ulrike Peters; Daniel O Stram; Maarit Tiirikainen; Lynne R Wilkens; Chunyuan Wu; Charles Kooperberg; Loïc Le Marchand
Journal:  PLoS One       Date:  2014-03-05       Impact factor: 3.240

  8 in total
  6 in total

1.  Identification of Pleiotropic Cancer Susceptibility Variants from Genome-Wide Association Studies Reveals Functional Characteristics.

Authors:  Yi-Hsuan Wu; Rebecca E Graff; Michael N Passarelli; Joshua D Hoffman; Elad Ziv; Thomas J Hoffmann; John S Witte
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2017-11-17       Impact factor: 4.254

Review 2.  Barrett's Esophagus and Esophageal Adenocarcinoma: How Common Are They Really?

Authors:  Aaron P Thrift
Journal:  Dig Dis Sci       Date:  2018-08       Impact factor: 3.199

Review 3.  Global burden and epidemiology of Barrett oesophagus and oesophageal cancer.

Authors:  Aaron P Thrift
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2021-02-18       Impact factor: 46.802

Review 4.  The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma.

Authors:  Gianmarco Contino; Thomas L Vaughan; David Whiteman; Rebecca C Fitzgerald
Journal:  Gastroenterology       Date:  2017-07-14       Impact factor: 22.682

Review 5.  Etiology and Prevention of Esophageal Cancer.

Authors:  Chung S Yang; Xiaoxin Chen; Shuiping Tu
Journal:  Gastrointest Tumors       Date:  2016-02-03

6.  Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts.

Authors:  Rebecca E Graff; Taylor B Cavazos; Khanh K Thai; Linda Kachuri; Sara R Rashkin; Joshua D Hoffman; Stacey E Alexeeff; Maruta Blatchins; Travis J Meyers; Lancelote Leong; Caroline G Tai; Nima C Emami; Douglas A Corley; Lawrence H Kushi; Elad Ziv; Stephen K Van Den Eeden; Eric Jorgenson; Thomas J Hoffmann; Laurel A Habel; John S Witte; Lori C Sakoda
Journal:  Nat Commun       Date:  2021-02-12       Impact factor: 14.919

  6 in total

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