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Literature DB >> 26363100

Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1.

Mathieu Métifiot¹, Samir Amrane², Jean-Louis Mergny³, Marie-Line Andreola⁴.

Abstract

During clinical trials, a number of fully characterized molecules are dropped along the way because they do not provide enough benefit for the patient. Some of them show limited side effects and might be of great use for other applications. AS1411 is a nucleolin-targeting aptamer that underwent phase II clinical trials as anticancer agent. Here, we show that AS1411 exhibits extremely potent antiviral activity and is therefore an attractive new lead as anti-HIV agent.

Entities: Chemical Species

Keywords: Anticancer; Antiviral; G-quadruplexes; Nucleolin; Zintevir

Mesh：

Substances：

Year: 2015 PMID： 26363100 DOI： 10.1016/j.biochi.2015.09.009

Source DB: PubMed Journal: Biochimie ISSN： 0300-9084 Impact factor: 4.079

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Cited

10 in total

1. Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase.

Authors: Antonella Messore; Angela Corona; Valentina Noemi Madia; Francesco Saccoliti; Valeria Tudino; Alessandro De Leo; Davide Ialongo; Luigi Scipione; Daniela De Vita; Giorgio Amendola; Ettore Novellino; Sandro Cosconati; Mathieu Métifiot; Marie-Line Andreola; Francesca Esposito; Nicole Grandi; Enzo Tramontano; Roberta Costi; Roberto Di Santo
Journal: J Med Chem Date: 2021-06-09 Impact factor: 7.446

2. G-quadruplex structure of an anti-proliferative DNA sequence.

Authors: Ngoc Quang Do; Wan Jun Chung; Thi Hong Anh Truong; Brahim Heddi; Anh Tuân Phan
Journal: Nucleic Acids Res Date: 2017-07-07 Impact factor: 16.971

3. G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents.

Authors: Efres Belmonte-Reche; Marta Martínez-García; Aurore Guédin; Michela Zuffo; Matilde Arévalo-Ruiz; Filippo Doria; Jenny Campos-Salinas; Marjorie Maynadier; José Juan López-Rubio; Mauro Freccero; Jean-Louis Mergny; José María Pérez-Victoria; Juan Carlos Morales
Journal: J Med Chem Date: 2018-01-27 Impact factor: 7.446

Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1.

1. Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase.

2. G-quadruplex structure of an anti-proliferative DNA sequence.

3. G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents.

4. Intra-locked G-quadruplex structures formed by irregular DNA G-rich motifs.

Review 5. G-quadruplex-based aptamers against protein targets in therapy and diagnostics.

Review 6. G-Quadruplex-Forming Aptamers-Characteristics, Applications, and Perspectives.

Review 7. Aptamers in Virology-A Consolidated Review of the Most Recent Advancements in Diagnosis and Therapy.

8. The G-quadruplex-forming aptamer AS1411 potently inhibits HIV-1 attachment to the host cell.

9. The cellular protein nucleolin preferentially binds long-looped G-quadruplex nucleic acids.

Review 10. Progress in cancer drug delivery based on AS1411 oriented nanomaterials.