PURPOSE: To develop and measure the reproducibility of 4-min whole brain myelin water fraction (MWF) mapping using fast acquisition with spiral trajectory and T2prep (FAST-T2) sequence at 3T. METHODS: Experiments were performed on phantoms, 13 volunteers, and 16 patients with multiple sclerosis. MWF maps were extracted using a spatially constrained non-linear algorithm. The proposed adiabatic modified BIR-4 (mBIR-4) T2prep was compared with the conventional composite T2prep (COMP). The effect of reducing the number of echo times (TEs) from 15 to 6 (reducing scan time from 10 to 4 min) was evaluated. Reproducibility was assessed using correlation analysis, coefficient of variation (COV), and Bland-Altman plots. RESULTS: Compared with COMP, mBIR-4 provided more accurate T2 in phantoms and better MWF maps in human brains. Reducing the number of TEs had a negligible effect on MWF map quality, with a regional MWF difference of <0.8%. Regional MWFs obtained by repeated scans showed excellent correlation (R = 0.99), low COV (1.3%-2.4%), and negligible bias within ±1% limits of agreement. On a voxel-wise basis, the agreement remained strong (correlation R = 0.89 ± 0.03, bias = 0.01% ± 0.29%, limits of agreement = [-3.35% ± 0.73%, 3.33% ± 0.61%]). CONCLUSION: Whole brain MWF mapping with adiabatic FAST-T2 is feasible in 4 min and provides good intrasite reproducibility. Magn Reson Med 76:456-465, 2016.
PURPOSE: To develop and measure the reproducibility of 4-min whole brain myelin water fraction (MWF) mapping using fast acquisition with spiral trajectory and T2prep (FAST-T2) sequence at 3T. METHODS: Experiments were performed on phantoms, 13 volunteers, and 16 patients with multiple sclerosis. MWF maps were extracted using a spatially constrained non-linear algorithm. The proposed adiabatic modified BIR-4 (mBIR-4) T2prep was compared with the conventional composite T2prep (COMP). The effect of reducing the number of echo times (TEs) from 15 to 6 (reducing scan time from 10 to 4 min) was evaluated. Reproducibility was assessed using correlation analysis, coefficient of variation (COV), and Bland-Altman plots. RESULTS: Compared with COMP, mBIR-4 provided more accurate T2 in phantoms and better MWF maps in human brains. Reducing the number of TEs had a negligible effect on MWF map quality, with a regional MWF difference of <0.8%. Regional MWFs obtained by repeated scans showed excellent correlation (R = 0.99), low COV (1.3%-2.4%), and negligible bias within ±1% limits of agreement. On a voxel-wise basis, the agreement remained strong (correlation R = 0.89 ± 0.03, bias = 0.01% ± 0.29%, limits of agreement = [-3.35% ± 0.73%, 3.33% ± 0.61%]). CONCLUSION: Whole brain MWF mapping with adiabatic FAST-T2 is feasible in 4 min and provides good intrasite reproducibility. Magn Reson Med 76:456-465, 2016.
Authors: Cornelia Laule; Piotr Kozlowski; Esther Leung; David K B Li; Alex L Mackay; G R Wayne Moore Journal: Neuroimage Date: 2008-03-05 Impact factor: 6.556
Authors: Sandra M Meyers; Irene M Vavasour; Burkhard Mädler; Trudy Harris; Eric Fu; David K B Li; Anthony L Traboulsee; Alex L MacKay; Cornelia Laule Journal: J Magn Reson Imaging Date: 2013-04-01 Impact factor: 4.813
Authors: Elizabeth R Jenista; Wolfgang G Rehwald; Enn-Ling Chen; Han W Kim; Igor Klem; Michele A Parker; Raymond J Kim Journal: Magn Reson Med Date: 2012-12-04 Impact factor: 4.668
Authors: Sneha Pandya; Ulrike W Kaunzner; Sandra M Hurtado Rúa; Nancy Nealon; Jai Perumal; Timothy Vartanian; Thanh D Nguyen; Susan A Gauthier Journal: J Neuroimaging Date: 2020-06-24 Impact factor: 2.486
Authors: S Zhang; T D Nguyen; S M Hurtado Rúa; U W Kaunzner; S Pandya; I Kovanlikaya; P Spincemaille; Y Wang; S A Gauthier Journal: AJNR Am J Neuroradiol Date: 2019-05-16 Impact factor: 3.825
Authors: Y Yao; T D Nguyen; S Pandya; Y Zhang; S Hurtado Rúa; I Kovanlikaya; A Kuceyeski; Z Liu; Y Wang; S A Gauthier Journal: AJNR Am J Neuroradiol Date: 2017-12-14 Impact factor: 3.825
Authors: Mustapha Bouhrara; David A Reiter; Michael C Maring; Jean-Marie Bonny; Richard G Spencer Journal: J Neuroimaging Date: 2018-07-12 Impact factor: 2.486
Authors: Cristina Granziera; Jens Wuerfel; Frederik Barkhof; Massimiliano Calabrese; Nicola De Stefano; Christian Enzinger; Nikos Evangelou; Massimo Filippi; Jeroen J G Geurts; Daniel S Reich; Maria A Rocca; Stefan Ropele; Àlex Rovira; Pascal Sati; Ahmed T Toosy; Hugo Vrenken; Claudia A M Gandini Wheeler-Kingshott; Ludwig Kappos Journal: Brain Date: 2021-06-22 Impact factor: 13.501