| Literature DB >> 26328879 |
Nanduri R Prabhakar1, Gregg L Semenza2.
Abstract
The discovery of carotid bodies as sensory receptors for detecting arterial blood oxygen levels, and the identification and elucidation of the roles of hypoxia-inducible factors (HIFs) in oxygen homeostasis have propelled the field of oxygen biology. This review highlights the gas-messenger signaling mechanisms associated with oxygen sensing, as well as transcriptional and non-transcriptional mechanisms underlying the maintenance of oxygen homeostasis by HIFs and their relevance to physiology and pathology. ©2015 Int. Union Physiol. Sci./Am. Physiol. Soc.Entities:
Mesh:
Substances:
Year: 2015 PMID: 26328879 PMCID: PMC4556828 DOI: 10.1152/physiol.00022.2015
Source DB: PubMed Journal: Physiology (Bethesda) ISSN: 1548-9221